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anti-Human DUOX2 Antikörper:
anti-Mouse (Murine) DUOX2 Antikörper:
anti-Rat (Rattus) DUOX2 Antikörper:
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Dog (Canine) Polyclonal DUOX2 Primary Antibody für ICC, IF - ABIN258884
Morand, Chaaraoui, Kaniewski, Dème, Ohayon, Noel-Hudson, Virion, Dupuy: Effect of iodide on nicotinamide adenine dinucleotide phosphate oxidase activity and Duox2 protein expression in isolated porcine thyroid follicles. in Endocrinology 2003
Show all 5 Pubmed References
High expression of DUOX2 is associated with dilated cardiomyopathy and impaired left ventricular function accompanied by increased risk of death.
Human neutrophil elastase (zeige ELANE Antikörper) is involved in transactivation of TLR4 (zeige TLR4 Antikörper) through activation of DUOX-2/EGFR (zeige EGFR Antikörper) and synergistically enhances IL-12p40 production by macrophages stimulated with LPS (zeige IRF6 Antikörper).
Monoallelic TSHR (zeige TSHR Antikörper) mutations are significantly associated with positive newborn screen for congenital hypothyroidism, and the association is further strengthened by the coexistence of monoallelic DUOX2 mutations.
In addition to thyroid hormonogenesis, the DUOX2 N-terminal domain may play a role in thyroid development.
This study reports the pedigree with goitrous congenital hypothyroidism (GCH (zeige GCH1 Antikörper)) due to the coexistence of heterozygous mutations in the DUOX2 and DUOXA2 (zeige DUOXA2 Antikörper) genes.
DUOX2 nonsense mutation plays a role in the pathogenesis of congenital hypothyroidism.
Expression of DUOX2 mRNA and protein was lower in gastric mucosa of patients with H. pylori infection compared to the uninfected. Among the H. pylori-infected patients, those having CagA (zeige S100A8 Antikörper) IgG or VacA in the serum had lower DUOX2 expression levels than those infected with H. pylori without either virulence factor.
xome sequencing identified candidate variants, including a missense mutation in DUOX2 that impaired its function and a frameshift mutation in CSF2RB (zeige CSF2RB Antikörper) that was associated with Crohn's Disease in an independent cohort of Ashkenazi Jewish individuals.
Data suggest that mutations in DUOX2 may be the most common cause of both permanent congenital hypothyroidism and transient hypothyroidism; severity of disease due to DUOX2 mutations may be milder than that due to other causes. This study involved neonatal screening of 48 Japanese boys and girls.
DUOX2 Mutation is associated with Congenital Hypothyroidism.
A novel recessive c.1226A>G transition of the dual oxidase 2 gene was identified as the causative mutation for a severe congenital hypothyroidism model together with anemia and T lymphopenia which mimics the clinical features of hypothyroid patients
the dual oxidase 2 N-terminal region is targeted to the plasma membrane
Both Nox1 (zeige NOX1 Antikörper) and Duox2 (zeige DUOX1 Antikörper) induce exfoliation of crypt epithelium, but only Nox1 (zeige NOX1 Antikörper) induces apoptosis. NOX1 (zeige NOX1 Antikörper) and DUOX2 (zeige DUOX1 Antikörper) may be potential therapeutic targets for treating ileocolitis in human patients suffering inflammatory bowel disease (IBD).
dual oxidase-2 (zeige DUOX1 Antikörper) and IL-6 (zeige IL6 Antikörper) play important roles in GPR43 (zeige FFAR2 Antikörper)-mediated skin inflammation.
We propose that Duox2 (zeige DUOX1 Antikörper) is responsible for IFN-independent signaling for induction of pattern recognition receptors transcription and can control acute Influenza virus A infection at the beginning of infection.
DUOX2 (zeige DUOX1 Antikörper) regulates interactions between the intestinal microbiota and the mucosa to maintain immune homeostasis in mice.
these data indicate that the gut (zeige GUSB Antikörper) microbiota uses two distinct signaling pathways to induce Duox2 (zeige DUOX1 Antikörper) expression in the ileum and colon epithelium.
Data suggest that proteinase-activated receptor 2 (zeige F2RL1 Antikörper) activation leads to up-regulation of the dual oxidase-2 (zeige DUOX1 Antikörper)/reactive oxygen species pathway in airway epithelial cells (AECs).
DUOX2 (zeige DUOX1 Antikörper)-generated ROS (zeige ROS1 Antikörper) induce AEC death.
a spontaneously generated valine 674-to-glycine mutation of murine Duox2 (zeige DUOX1 Antikörper) results in a translocation defect and complete loss of function that explains the severe congenital hypothyroid phenotype of the thyd/thyd mouse strain
DUOX2 (zeige DUOX1 Antikörper) plays pivotal roles in TLR5 (zeige TLR5 Antikörper)-dependent inflammatory response of nasal airway epithelium.
DUOX2 (zeige DUOX1 Antikörper) and NOD2 (zeige NOD2 Antikörper) cooperatively facilitate antibacterial action.
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain.
dual oxidase 2
, dual oxidase 2-like
, NADH/NADPH thyroid oxidase p138-tox
, NADPH oxidase/peroxidase DUOX2
, NADPH thyroid oxidase 2
, dual oxidase-like domains 2
, flavoprotein NADPH oxidase
, large NOX 2
, long NOX 2
, nicotinamide adenine dinucleotide phosphate oxidase
, p138 thyroid oxidase
, thyroid oxidase 2
, NADH/NADPH thyroid oxidase THOX2