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Human Monoclonal CSK Primary Antibody für ICC, FACS - ABIN969069
Levy, Ehret, Rice, Verwoert, Launer, Dehghan, Glazer, Morrison, Johnson, Aspelund, Aulchenko, Lumley, Köttgen, Vasan, Rivadeneira, Eiriksdottir, Guo, Arking, Mitchell, Mattace-Raso, Smith, Taylor et al.: Genome-wide association study of blood pressure and hypertension. ... in Nature genetics 2010
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Human Polyclonal CSK Primary Antibody für IHC (p), IHC - ABIN256941
Holtrich, Bräuninger, Strebhardt, Rübsamen-Waigmann: Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase. in Proceedings of the National Academy of Sciences of the United States of America 1992
Human Polyclonal CSK Primary Antibody für ICC, IF - ABIN4300691
Gallagher, Rambow, Kumasaka, Champeval, Bellacosa, Delmas, Larue: Beta-catenin inhibits melanocyte migration but induces melanoma metastasis. in Oncogene 2013
These results identified a novel role for Csk as a host tyrosine kinase (zeige TXK Antikörper) involved in dengue virus replication.
Domain interactions of C-terminal Src Kinase determined through NMR spectroscopy with segmental isotope labeling
Data suggest that myristoylation of Src kinase is essential to facilitate Src (zeige SRC Antikörper)-induced and high-fat diet-accelerated prostatic tumor progression; targeting Src kinase myristoylation, which is required for Src kinase association at cellular membrane, blocks dietary fat-accelerated tumorigenesis.
Linear mixed-effect regressions showed significant association between rs1378942 in CSK and systolic blood pressure (beta = 0.98+/-0.46, P = 3.4x10-2). The child genotype scores for diastolic and systolic blood pressure were not associated in children.
H2O2-induced Csk translocation to the plasma membrane leads to phosphorylation of Src at the tyrosine 530 residue resulting in a reduction of ERK1/2 phosphorylation.
Data suggest that as a natural inhibitor of c-Src kinase, naringin could be an effective candidate for the treatment of melanoma.
deregulation of the Pragmin-Csk axis may induce aberrant cell migration that contributes to tumor invasion and metastasis
Our results do not support association between PTPN22 (zeige PTPN22 Antikörper)/CSK and Henoch-Schonlein purpura
Results identify CSK downregulation as a principal driver of SRC (zeige SRC Antikörper) activation and castration resistance.
Variant rs1378942 near CSK was nominally associated with systolic blood pressure in a Chinese population.
Our results have uncovered a previously unknown role of c-Src tyrosine kinase in regulating interneuron function in the brain and identified a novel mechanism by which TASK-1 (zeige KCNK3 Antikörper) channels are activated in neurons.
in the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells.
Csk is a causative gene in the 15q24 locus and regulates blood pressure through Src (zeige SRC Antikörper), and these findings provide a novel therapeutic target for the treatment of hypertension
Csk plays an important role, not only in basal signaling, but also in setting the T cell antigen receptor signaling threshold and affinity recognition.
SHIP1 (zeige INPP5D Antikörper) and Csk are part of the PSTPIP2 (zeige PSTPIP2 Antikörper)-dependent inhibitory network that prevents the development of autoinflammatory disease.
If Cbp enhances the interaction between c-Src and FAK, Cbp could promote c-Src function when lipid rafts are disrupted.
Suggest critical role of Cav1 in modulating cSrc activation, gap junction remodeling, and ventricular arrhythmias.
Differentiation of embryonic stem cells is driven by c-Src (zeige SRC Antikörper) is antagonized by c-Yes (zeige YES1 Antikörper).
critical role in preventing TCR signaling
It was concluded that c-Src (zeige SRC Antikörper) and NADPH oxidase (zeige NOX1 Antikörper) components are necessary for redox-mediated production of TNF-alpha (zeige TNF Antikörper) following liver ischemia-reperfusion and that hepatocytes play an important role in this process.
Dok-4 (zeige DOK4 Antikörper) has a role as an anchoring molecule for the tyrosine kinase (zeige TYRO3 Antikörper) c-Src (zeige SRC Antikörper), and in turn as a regulator of TNF-alpha (zeige TNF Antikörper)-mediated ROS (zeige ROS1 Antikörper) production and NF-kappaB (zeige NFKB1 Antikörper) activation
Src (zeige SRC Antikörper) family tyrosine kinases play a central role of arginase and inducible nitric oxide synthase (zeige NOS2 Antikörper) in pulmonary artery endothelium.
Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells.
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity).
, protein-tyrosine kinase CYL
, tyrosine-protein kinase CSK
, protein-tyrosine kinase MPK-2
, C-SRC kinase
, protein-tyrosine kinase (CSK)
, protein kinase
, src kinase