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CSK Produkte

(C-Src tyrosine Kinase (CSK))

Kategorien

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity).

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Ausgewählte CSK Kategorien

CSK Antikörper

High quality antibodies with extensive validation data.

CSK ELISA Kits

Reliable ELISA kits for a wide range of species.

CSK Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene CSK Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation ELISA, WB
Validierungen
  • (4)
Kat. Nr. ABIN184606
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation IHC (p), WB
Validierungen
  • (3)
Kat. Nr. ABIN3042764
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, IHC, WB
Validierungen
  • (2)
Kat. Nr. ABIN7174015
Menge 100 μL
Datenblatt Datenblatt

Empfohlene CSK ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6965267
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validierungen
Kat. Nr. ABIN1380162
Menge 2 x 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN4886032
Menge 96 tests
Datenblatt Datenblatt

Empfohlene CSK Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
  • (1)
Kat. Nr. ABIN1350517
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source HEK-293 Cells
Validierungen
  • (2)
Kat. Nr. ABIN2712578
Menge 20 μg
Datenblatt Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
  • (2)
Kat. Nr. ABIN5570539
Menge 100 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren CSK Produkten

Jo, Park, Lee, Ahn, Kim, Park, Choi: "SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes." in: PLoS ONE, Vol. 9, Issue 3, pp. e91582, (2014) (PubMed).

Trepanier, Lei, Xie, MacDonald: "Group II metabotropic glutamate receptors modify N-methyl-D-aspartate receptors via Src kinase." in: Scientific reports, Vol. 3, pp. 926, (2013) (PubMed).

Gallagher, Rambow, Kumasaka, Champeval, Bellacosa, Delmas, Larue: "Beta-catenin inhibits melanocyte migration but induces melanoma metastasis." in: Oncogene, Vol. 32, Issue 17, pp. 2230-8, (2013) (PubMed).

Levy, Ehret, Rice, Verwoert, Launer, Dehghan, Glazer, Morrison, Johnson, Aspelund, Aulchenko, Lumley, Köttgen, Vasan, Rivadeneira, Eiriksdottir, Guo, Arking, Mitchell, Mattace-Raso, Smith, Taylor et al.: "Genome-wide association study of blood pressure and hypertension. ..." in: Nature genetics, Vol. 41, Issue 6, pp. 677-87, (2010) (PubMed).

Ho, Levy, Rose, Johnson, Ridker, Chasman: "Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study." in: Journal of hypertension, Vol. 29, Issue 1, pp. 62-9, (2010) (PubMed).

Kreil, Hochhaus, Cross, Chase: "A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias." in: Leukemia research, Vol. 33, Issue 9, pp. e168-9, (2009) (PubMed).

Zhang, Kalyankrishna, Wislez, Thilaganathan, Saigal, Wei, Ma, Wistuba, Johnson, Kurie: "SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines." in: The American journal of pathology, Vol. 170, Issue 1, pp. 366-76, (2007) (PubMed).

Lin, Lee, Sun: "Functions of the activation loop in Csk protein-tyrosine kinase." in: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 24072-7, (2003) (PubMed).

Huang, Chen, Inoue, Chen: "Tyrosine phosphorylation of I-kappa B kinase alpha/beta by protein kinase C-dependent c-Src activation is involved in TNF-alpha-induced cyclooxygenase-2 expression." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 9, pp. 4767-75, (2003) (PubMed).

Natarajan, Rajala, Chodosh: "Corneal IL-8 expression following adenovirus infection is mediated by c-Src activation in human corneal fibroblasts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 12, pp. 6234-43, (2003) (PubMed).

Synonyme und alternative Namen zu CSK

C-terminal Src kinase (CSK), c-src tyrosine kinase (Csk), C-terminal Src kinase (Csk), c-src tyrosine kinase (CSK), CSK, non-receptor tyrosine kinase (CSK), AW212630

Bezeichner auf Proteinebene für CSK

  • C-Src kinase
  • protein-tyrosine kinase CYL
  • tyrosine-protein kinase CSK
  • p50CSK
  • protein-tyrosine kinase MPK-2
  • C-SRC kinase
  • protein-tyrosine kinase (CSK)
  • protein kinase
  • src kinase
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