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Mouse (Murine) Polyclonal GRIN2C Primary Antibody für WB - ABIN1881390
Krapivinsky, Krapivinsky, Manasian, Ivanov, Tyzio, Pellegrino, Ben-Ari, Clapham, Medina: The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. in Neuron 2003
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Findings indicate that SNPs in the GRIN2C gene is associated with altered cue-induced brain activation that is related to craving for alcohol and relapse risk.
these findings highlight the isoform-specific structural and functional differences within the 14-3-3 (zeige YWHAQ Antikörper) family of proteins, which determine GluN2C binding and its essential role in targeting the receptor to the cell surface
NMDARs have a dual role during erythropoiesis, supporting survival of polychromatic erythroblasts and contributing to the Ca(2 (zeige CA2 Antikörper)+) homeostasis from the orthochromatic erythroblast stage to circulating red blood cells.
The major depression subjects exhibited significantly higher expression levels of the NMDA receptor subunit genes GRIN2C.
Reduction in NR1 (zeige GRIN1 Antikörper) and NR2C in the DLPFC of people with schizophrenia may lead to altered NMDAR (zeige GRIN1 Antikörper) stoichiometry and provides compelling evidence for an endogenous NMDAR (zeige GRIN1 Antikörper) deficit in schizophrenia.
TNFalpha (zeige TNF Antikörper) significantly upregulates NMDA-R2C mRNA expression, in differentiated, confluent, normal keratinocytes but not in involved or uninvolved psoriatic keratinocyte monolayers
Functional compensation could occur to counteract the loss of one allele in GRIN2C and GRIN3 (zeige GPRIN3 Antikörper) family genes.
The results demonstrate that loss of GluN2C subunit leads to cortical excitatory-inhibitory imbalance and abnormal neuronal oscillations associated with neurodevelopmental disorders.
a neuroprotective role of GluN2C, suggesting a mechanism by which GluN2C is upregulated to promote neuronal survival following ischemia.
The GluN2C subunit enhances ischemic stroke pathology by promoting neuronal dysfunction in the penumbra (zeige TSPAN33 Antikörper) region.
glutamatergic glial transmission is sensed by neurons of the dorsal Suprachiasmatic nucleus via specific pre-synaptic NMDA receptor assemblies containing NR2C subunits.
Tuberless heterozygote Tsc1 (zeige TSC1 Antikörper)+/- mice show functional up-regulation of cortical GluN2C receptors in an mTOR (zeige FRAP1 Antikörper)-dependent manner, exhibit recurrent, unprovoked seizures during early postnatal life, that can be treated with GluN2C antagonists.
low rectification normally observed in the nucleus reticularis of the thalamus is due to NR2C
No differences in expression of NR2A (zeige GRIN2A Antikörper), NR2C or NR2D (zeige GRIN2D Antikörper) are found in any brain region examined during ethanol consumption and acute ethanol withdrawal.
Study shows that the NR2C and Tiam1 (zeige TIAM1 Antikörper) maturation genes are synergistically controlled by the activity-dependent induction of Etv1 (zeige ETV1 Antikörper).
Findings suggest a unique role of NR2C-containing receptors in associative and executive learning. NR2C knockout mice were found to exhibit deficits in fear acquisition and working memory.
indicate that SNX27 (zeige SNX27 Antikörper) may function to regulate endocytosis and/or endosomal sorting of NR2C
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).
glutamate receptor, ionotropic, N-methyl D-aspartate 2C
, interleukin 12 receptor beta 2.b
, interleukin 12 receptor, beta 2a, like
, N-methyl-D-aspartate receptor subunit 2C
, ionotropic glutamate receptor subunit NR2C
, glutamate [NMDA] receptor subunit epsilon-3-like
, N-methyl D-aspartate receptor subtype 2C
, NMDA glutamate receptor
, glutamate [NMDA] receptor subunit epsilon-3
, glutamate receptor ionotropic, NMDA 2C
, glutamate receptor, ionotropic, NMDA2C