anti-GRIN2C (GRIN2C) Antikörper

Human Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) Interaktionspartner

1. ultra-rare variants with loss of function (frameshift, nonsense or splice site) in NMDARs genes like GRIN2C and GRIN2D may contribute to possible risk of schizophrenia

2. Findings indicate that SNPs in the GRIN2C gene is associated with altered cue-induced brain activation that is related to craving for alcohol and relapse risk.

3. these findings highlight the isoform-specific structural and functional differences within the 14-3-3 family of proteins, which determine GluN2C binding and its essential role in targeting the receptor to the cell surface

4. NMDARs have a dual role during erythropoiesis, supporting survival of polychromatic erythroblasts and contributing to the Ca(2+) homeostasis from the orthochromatic erythroblast stage to circulating red blood cells.

5. The major depression subjects exhibited significantly higher expression levels of the NMDA receptor subunit genes GRIN2C.

6. Reduction in NR1 and NR2C in the DLPFC of people with schizophrenia may lead to altered NMDAR stoichiometry and provides compelling evidence for an endogenous NMDAR deficit in schizophrenia.

7. TNFalpha significantly upregulates NMDA-R2C mRNA expression, in differentiated, confluent, normal keratinocytes but not in involved or uninvolved psoriatic keratinocyte monolayers

8. The authors identified and cloned sequences of NMDA receptor subunits 2A, 2B, and 2C from rat. They characterized the properties of the receptors composed of heteromeric 1-2A and heteromeric 1-2C and found that the latter had reduced sensitivity to magnesium and smaller conductance compared to the former.

9. Functional compensation could occur to counteract the loss of one allele in GRIN2C and GRIN3 family genes.

Mouse (Murine) Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C) Interaktionspartner

1. The results demonstrate that loss of GluN2C subunit leads to cortical excitatory-inhibitory imbalance and abnormal neuronal oscillations associated with neurodevelopmental disorders.

2. a neuroprotective role of GluN2C, suggesting a mechanism by which GluN2C is upregulated to promote neuronal survival following ischemia.

3. The GluN2C subunit enhances ischemic stroke pathology by promoting neuronal dysfunction in the penumbra region.

4. glutamatergic glial transmission is sensed by neurons of the dorsal Suprachiasmatic nucleus via specific pre-synaptic NMDA receptor assemblies containing NR2C subunits.

5. Tuberless heterozygote Tsc1+/- mice show functional up-regulation of cortical GluN2C receptors in an mTOR-dependent manner, exhibit recurrent, unprovoked seizures during early postnatal life, that can be treated with GluN2C antagonists.

6. low rectification normally observed in the nucleus reticularis of the thalamus is due to NR2C

7. No differences in expression of NR2A, NR2C or NR2D are found in any brain region examined during ethanol consumption and acute ethanol withdrawal.

8. Study shows that the NR2C and Tiam1 maturation genes are synergistically controlled by the activity-dependent induction of Etv1.

9. Findings suggest a unique role of NR2C-containing receptors in associative and executive learning. NR2C knockout mice were found to exhibit deficits in fear acquisition and working memory.

10. indicate that SNX27 may function to regulate endocytosis and/or endosomal sorting of NR2C

11. Expression of GluRepsilon 3 is essential for postsynaptic localization and protein stability of the GluRzeta1 subunit.

12. The spiny stellate neurons of barrel cortex layer 4 functionally express NR2C subunits; this is the likely explanation for their ability to generate large NMDAR-mediated EPSPs that are effective at resting potential, without previous depolarization.

13. results show that the NR2C by NR2B subunit exchange in mice affects ACh content in two target areas of the nucleus basalis

14. Results suggest that the replacement of subunit NR2C by NR2B in juvenile mice increases anxiety- and fear-related behaviors possibly due to changes in frontal cortex serotonin and periaqueductal grey acetylcholine levels.

15. stimulation of NMDA receptors in conjunction with the AMPA receptor-mediated excitation of granule cells plays a key role in functional subunit switching of NMDA receptors in maturing granule cells at the physiological KCl concentration