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anti-Human CHRNA7 Antikörper:
anti-Mouse (Murine) CHRNA7 Antikörper:
anti-Rat (Rattus) CHRNA7 Antikörper:
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Rat (Rattus) Polyclonal CHRNA7 Primary Antibody für ELISA, IHC - ABIN2750640
Severance, Zhang, Cruz, Pakhlevaniants, Hadley, Amin, Wecker, Reed, Cuevas: The alpha7 nicotinic acetylcholine receptor subunit exists in two isoforms that contribute to functional ligand-gated ion channels. in Molecular pharmacology 2004
The association between amyloid-beta burden and alpha7-nAChR reduction in the basal forebrain cholinergic system was highlighted in relation to cognitive decline in Alzheimer's disease.
This report describes the development and validation of a high-throughput, genome-wide cDNA screening platform coupled to FLIPR functional assays in order to identify functional modulators of alpha7nAChR signaling
In our analysis, we found one pair of SNPs in CHRNA1 and CHRNA7, plus one pair of SNPs in CHRNA2 and CHRNA3 reached corrected significance in tests for GxG interaction. Our study suggested evidence of interactions between CHRNs in controlling the risk of NSCL/P.
alpha7 nAChR may play an important role in neuropathology caused by gp120.
These findings demonstrate that a7nAChR plays an important role in H1299 cell proliferation, tumor growth and expression of vimentin. Therefore, blocking a7nAChRs in non-small cell lung cancer (NSCLC) may be a potential adjuvant therapy for the targeted treatment of NSCLC
Results revealed that alpha7nAChR expressed in tumor-associated macrophages may play an important role in preventing metastasis through the JAK2/STAT3 signaling pathway and could be a prognosis marker in colorectal cancer.
Study found no significant association was between CHRNA7 and vascular dementia.
CHRNA7 regulates osteoclast differentiation during physiological root resorption.
This study found the rs6494223 TC genotype within CHRNA7 increasing the risk for Bipolar Disorder.
these results indicate that nicotine induces non-small cell lung cancer cell invasion, migration, and epithelial to mesenchymal transition ; the effects are mediated by alpha7-nAChRs and involve MEK/ERK signaling pathway
the mechanism of interaction between [Upsilon4E]GID and the agonist binding pockets of the alpha4beta2 and the halpha7 receptors, and to estimate their relative binding affinities, was investigated.
This study describes screening methodology for identifying bioactive compounds in mixtures acting on the alpha7-nAChR. The methodology developed combines liquid chromatography (LC) coupled via a split with both an at-line calcium (Ca(2+))-flux assay and high-resolution mass spectrometry (MS)
The authors propose a mechanism for the pathogenicity of CHRNA7 duplications of increased alpha7 Nicotinic Acetylcholine Receptor protein levels in the Endoplasmic Reticulum, resulting in Endoplasmic Reticulum stress and impaired chaperoning of alpha7 Nicotinic Acetylcholine Receptor subunits to the membrane.
Immunopositivity of alpha7-nAChR in granular layers was observed in most of the fetuses and infants in the control group (83%) and several victims of the SIUDS or SIDS groups (38% and 31%, respectively). On the contrary, low levels or total absence of alpha7-nAChR immunoexpression were detected in a wide subset (over 50% of the cases) of sudden fetal and infant deaths, which was highly related to maternal smoking.
alpha7nAChR activation inhibits the development of endometriosis by regulating inflammation.
level of alpha7 nAChR expression in the brain is critical for supporting the resistance to inflammatory and apoptogenic agents; the data presented may be a basis to create a new strategy for preventing and, possibly, slowing Alzheimer's disease development in humans
Activated alpha7nAChR exhibits extensive anti-inflammatory and immune modulatory reactions, including lowered pro-inflammatory cytokines levels, decreased expressions of chemokines as well as adhesion molecules, and altered differentiation and activation of immune cells, which are important in maintaining immune homeostasis.
Varenicline promotes HUVEC migration by lowering VE-cadherin expression due to activated ERK/p38/JNK signaling through alpha7 nAChR. These processes probably contribute to varenicline-aggravated atherosclerotic plaque.
Comprehensive phenotyping revealed high prevalence of developmental delay/intellectual disability, autism spectrum disorder, and attention deficit/hyperactivity disorder in children with microduplications involving CHRNA7.
These results support our previous study showing that these PAMs are selective for the alpha7 AChR, and clarify that the procognitive/promnesic/antidepressant activity of PAM-2 is not mediated by other targets.
Thus, vagal nerve stimulation of macrophages via alpha7nAchR regulates bone mass by modulating osteoclast formation.
In this study we used genetic deletion of the alpha7nAChR to confirm our previous inhibitor studies that demonstrated NNK stimulates pancreatitis by activating this receptor. Lastly, we demonstrate that NNK can also stimulate zymogen activation in human acinar cells and thus may play a role in human disease
Results show that the p38 MAPK signaling pathway could regulate mitochondria Abeta internalization by manipulating the expression of alpha7nAChR. Pretreatment of alpha7nAChR agonist could attenuate these biochemical changes which are tightly associated with Abeta1-42 induced apoptosis. Suggesting there is an endogenous, previously unrecognized cholinergic mechanism to control mitochondria functions and their apoptotic ...
These findings provide evidence that alpha7nAChR activation mitigates chronic restraint stress -induced neuroinflammation and cell death
Study demonstrated that activating alpha7nAChR contributed to the inhibition of NLRP3 inflammasome activation through the beta-arrestin-1-mediated manner in experimental auto-immune encephalomyelitis.
Nicotine stimulates fibroblast proliferation and their expression of collagen type I through alpha7 nAChRs, thereby altering the relative composition of the lung matrix.
Stimulation of nAChRalpha7 with GTS-21 reduced atherosclerosis, which was associated with dampened splenic myelopoiesis in ApoE knockout mice.
increased BDNF-TrkB signaling and synaptogenesis in the nucleus accumbens by deletion of alpha7 nAChR plays a key role in depression
The in vitro findings suggest that GTS-21-induced IL-6 release from muscle is mediated via alpha7AChRs upstream of Stat-3 and -5 pathways and is associated with myonuclear accretion, possibly via MyoD and Pax7 expression.
alpha7nAChR stimulation reduced neuroinflammation via activation of the JAK2-STAT3 pathway, thereby ameliorating the short- and long-term sequelae after intracerebral hemorrhage .
In alpha7 nAChR knock-out mice, withdrawal from nicotine does not result in withdrawal-induced inattention.
MeCP2 is critical for normal function of cholinergic neurons and dysfunction of cholinergic neurons can contribute to numerous neuropsychiatric phenotypes.
the data suggest involvement of nAChRs of alpha7 subtype in regulation of specific neutrophil functions
The results suggest that alpha7nAChR has a central role in modulating the response to chronic cigarette smoking that could include altering susceptibility to associated lung diseases including fibrosis and cancer.
Regulation of expression level and splicing of RIC-3 in brain and in immune cells following inflammation enables regulation of nicotinic acetylcholine receptor functional expression.
The collective results suggest that PNU-282987, an agonist of alpha7nAChR, reduces lipopolysaccharide-induced experimental acute lung injury.
these results demonstrate that vagus nerve stimulation-mediated attenuation of acute kidney injury and systemic inflammation depends on alpha7nAChR-positive splenocytes.
Data (including data from studies conducted using knockout mice and SH-SY5Y cell line) suggest that Wnt/beta-catenin signaling is critical effector of Chrna7-associated neuroprotection of dopaminergic neurons in substantia nigra; Parkinson's disease appears to develop without this neuroprotection.
Cigarette smoke extract and nicotine-induced fibroblast proliferation and collagen content were mediated through alpha7 nicotinic acetylcholine receptors.
Results suggest that a nearly similar TBI-induced decrease in the alpha7 density in the brain of immature and adult animals is found, even with the differences in species, age and experimental procedures.
We conclude that residues in the M2 segment and flanking regions contribute to the unusual properties of the CHRNA7 receptor
Deletion of a small cytoplasmic fragment close to the fourth transmembrane segment of the nicotinic alpha7 receptor (Glu437 to Arg447) abolished membrane expression
Data show that basic residues at positions 208 and 210 are necessary for the assembly of alpha7 receptors.
Cultured bovine retinal pigment epitheliumcells expressed nicotinic receptors containing alpha7 subunit
Loop 9 has a different role in the function of homomeric and heteromeric receptors.
Loop 3 and its docking to the alpha-helix is an important requirement for receptor assembly of the alpha7 nicotinic receptor.
Bovine chromaffin cells have an alpha3alpha7beta4 nicotinic receptor
a network of interactions formed by residues Lys-46, Asp-128, Asp-135, Asp-266, and possibly others appears to link agonist binding to channel gating
involvement of Lys145 in the early steps of channel activation by acetylcholine
slowly desensitizing mutant alpha7L248T could be an interesting tool for the study of channel activation in alpha7 receptors
Nicotinic alpha7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex.
Lynx1 appears to act as a negative modulator of alpha7 nAChR-induced events by inhibiting Src activation.
Chronic nicotine exposure up-regulates nAChR activity in developing lung, and that nAChR activity can be further modified by tyrosine phosphorylation.
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.
a7 nicotinic acetylcholine receptor
, alpha 7 neuronal nicotinic acetylcholine receptor
, alpha-7 nicotinic cholinergic receptor subunit
, cholinergic receptor, nicotinic, alpha polypeptide 7
, neuronal acetylcholine receptor protein, alpha-7 chain
, neuronal acetylcholine receptor subunit alpha-7
, cholinergic receptor, nicotinic, alpha 7
, neuronal acetylcholine receptor subunit alpha-7-like
, acetylcholine receptor alpha 7 neural
, alpha7 nicotinic receptor
, C holinergic receptor nicotinic alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)
, C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)
, bungarotoxin alpha
, neuronal nicotinic acetycholine receptor alpha 7
, nicotinic receptor alpha 7 subunit
, cholinergic receptor nicotinic alpha 7
, alpha 7 nicotinic acetylcholine receptor
, nicotinic acetylcholine receptor alpha7
, CHRNA7-FAM7A fusion protein
, cholinergic receptor, nicotinic, alpha 7 (neuronal)