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anti-Human CHRNA7 Antikörper:
anti-Mouse (Murine) CHRNA7 Antikörper:
anti-Rat (Rattus) CHRNA7 Antikörper:
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Rat (Rattus) Polyclonal CHRNA7 Primary Antibody für ELISA, IHC - ABIN2750640
Severance, Zhang, Cruz, Pakhlevaniants, Hadley, Amin, Wecker, Reed, Cuevas: The alpha7 nicotinic acetylcholine receptor subunit exists in two isoforms that contribute to functional ligand-gated ion channels. in Molecular pharmacology 2004
These findings demonstrate that a7nAChR plays an important role in H1299 cell proliferation, tumor growth and expression of vimentin (zeige VIM Antikörper). Therefore, blocking a7nAChRs in non-small cell lung cancer (NSCLC) may be a potential adjuvant therapy for the targeted treatment of NSCLC
Results revealed that alpha7nAChR expressed in tumor-associated macrophages may play an important role in preventing metastasis through the JAK2 (zeige JAK2 Antikörper)/STAT3 (zeige STAT3 Antikörper) signaling pathway and could be a prognosis marker in colorectal cancer.
Study found no significant association was between CHRNA7 and vascular dementia.
CHRNA7 regulates osteoclast differentiation during physiological root resorption.
This study found the rs6494223 TC genotype within CHRNA7 increasing the risk for Bipolar Disorder.
these results indicate that nicotine induces non-small cell lung cancer cell invasion, migration, and epithelial to mesenchymal transition ; the effects are mediated by alpha7-nAChRs and involve MEK (zeige MAP2K1 Antikörper)/ERK (zeige EPHB2 Antikörper) signaling pathway
This study describes screening methodology for identifying bioactive compounds in mixtures acting on the alpha7-nAChR. The methodology developed combines liquid chromatography (LC) coupled via a split with both an at-line calcium (Ca(2 (zeige CA2 Antikörper)+))-flux assay and high-resolution mass spectrometry (MS)
The authors propose a mechanism for the pathogenicity of CHRNA7 duplications of increased alpha7 Nicotinic Acetylcholine Receptor protein levels in the Endoplasmic Reticulum, resulting in Endoplasmic Reticulum stress and impaired chaperoning of alpha7 Nicotinic Acetylcholine Receptor subunits to the membrane.
Immunopositivity of alpha7-nAChR in granular layers was observed in most of the fetuses and infants in the control group (83%) and several victims of the SIUDS or SIDS (zeige IDS Antikörper) groups (38% and 31%, respectively). On the contrary, low levels or total absence of alpha7-nAChR immunoexpression were detected in a wide subset (over 50% of the cases) of sudden fetal and infant deaths, which was highly related to maternal smoking.
level of alpha7 nAChR expression in the brain is critical for supporting the resistance to inflammatory and apoptogenic agents; the data presented may be a basis to create a new strategy for preventing and, possibly, slowing Alzheimer's disease development in humans
Study demonstrated that activating alpha7nAChR contributed to the inhibition of NLRP3 (zeige NLRP3 Antikörper) inflammasome activation through the beta-arrestin-1 (zeige ARRB1 Antikörper)-mediated manner in experimental auto-immune encephalomyelitis.
Stimulation of nAChRalpha7 with GTS-21 reduced atherosclerosis, which was associated with dampened splenic myelopoiesis in ApoE (zeige APOE Antikörper) knockout mice.
increased BDNF (zeige BDNF Antikörper)-TrkB (zeige NTRK2 Antikörper) signaling and synaptogenesis in the nucleus accumbens by deletion of alpha7 nAChR plays a key role in depression
The in vitro findings suggest that GTS-21-induced IL-6 (zeige IL6 Antikörper) release from muscle is mediated via alpha7AChRs upstream of Stat-3 (zeige STAT3 Antikörper) and -5 pathways and is associated with myonuclear accretion, possibly via MyoD (zeige MYOD1 Antikörper) and Pax7 (zeige PAX7 Antikörper) expression.
alpha7nAChR stimulation reduced neuroinflammation via activation of the JAK2 (zeige JAK2 Antikörper)-STAT3 (zeige STAT3 Antikörper) pathway, thereby ameliorating the short- and long-term sequelae after intracerebral hemorrhage .
In alpha7 nAChR knock-out mice, withdrawal from nicotine does not result in withdrawal-induced inattention.
MeCP2 is critical for normal function of cholinergic neurons and dysfunction of cholinergic neurons can contribute to numerous neuropsychiatric phenotypes.
Regulation of expression level and splicing of RIC-3 in brain and in immune cells following inflammation enables regulation of nicotinic acetylcholine receptor functional expression.
These results support our previous study showing that these PAMs are selective for the alpha7 AChR, and clarify that the procognitive/promnesic/antidepressant activity of PAM (zeige PAM Antikörper)-2 is not mediated by other targets.
Data (including data from studies conducted using knockout mice and SH-SY5Y cell line) suggest that Wnt/beta-catenin signaling is critical effector of Chrna7-associated neuroprotection of dopaminergic neurons in substantia nigra; Parkinson's disease appears to develop without this neuroprotection.
Results suggest that a nearly similar TBI-induced decrease in the alpha7 density in the brain of immature and adult animals is found, even with the differences in species, age and experimental procedures.
We conclude that residues in the M2 segment and flanking regions contribute to the unusual properties of the CHRNA7 receptor
Loop 3 and its docking to the alpha-helix is an important requirement for receptor assembly of the alpha7 nicotinic receptor.
a network of interactions formed by residues Lys (zeige LYZ Antikörper)-46, Asp (zeige ASIP Antikörper)-128, Asp (zeige ASIP Antikörper)-135, Asp (zeige ASIP Antikörper)-266, and possibly others appears to link agonist binding to channel gating
Lynx1 (zeige LYNX1 Antikörper) appears to act as a negative modulator of alpha7 nAChR-induced events by inhibiting Src (zeige SRC Antikörper) activation.
Chronic nicotine exposure up-regulates nAChR (zeige CHRNA4 Antikörper) activity in developing lung, and that nAChR (zeige CHRNA4 Antikörper) activity can be further modified by tyrosine phosphorylation.
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.
a7 nicotinic acetylcholine receptor
, alpha 7 neuronal nicotinic acetylcholine receptor
, alpha-7 nicotinic cholinergic receptor subunit
, cholinergic receptor, nicotinic, alpha polypeptide 7
, neuronal acetylcholine receptor protein, alpha-7 chain
, neuronal acetylcholine receptor subunit alpha-7
, cholinergic receptor, nicotinic, alpha 7
, neuronal acetylcholine receptor subunit alpha-7-like
, acetylcholine receptor alpha 7 neural
, alpha7 nicotinic receptor
, C holinergic receptor nicotinic alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)
, C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)
, bungarotoxin alpha
, neuronal nicotinic acetycholine receptor alpha 7
, nicotinic receptor alpha 7 subunit
, cholinergic receptor nicotinic alpha 7
, alpha 7 nicotinic acetylcholine receptor
, nicotinic acetylcholine receptor alpha7
, CHRNA7-FAM7A fusion protein
, cholinergic receptor, nicotinic, alpha 7 (neuronal)