CHRNA7 Antikörper (AA 23-230)

Produktnummer ABIN6138583

Produktdetails anti-CHRNA7 Antikörper

Target: CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7))

Bindungsspezifität: AA 23-230

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHRNA7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequenz: ASPPSTPPWD PGHIPGASVR PAPGPVSLQG EFQRKLYKEL VKNYNPLERP VANDSQPLTV YFSLSLLQIM DVDEKNQVLT TNIWLQMSWT DHYLQWNVSE YPGVKTVRFP DGQIWKPDIL LYNSADERFD ATFHTNVLVN SSGHCQYLPP GIFKSSCYID VRWFPFDVQH CKLKFGSWSY GGWSLDLQMQ EADISGYIPN GEWDLVGI

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 23-230 of human CHRNA7 (NP_001177384.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu CHRNA7

Target: CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7))

Andere Bezeichnung: CHRNA7 (CHRNA7 Produkte)

Synonyme: CHRNA7-2 antikoerper, NACHRA7 antikoerper, dZ70B1.1 antikoerper, Acra7 antikoerper, alpha7 antikoerper, BTX antikoerper, NARAD antikoerper, nAChRa7 antikoerper, CHRNA7 antikoerper, cholinergic receptor nicotinic alpha 7 subunit antikoerper, neuronal acetylcholine receptor subunit alpha-7 antikoerper, cholinergic receptor, nicotinic, alpha 7 (neuronal) antikoerper, cholinergic receptor, nicotinic, alpha polypeptide 7 antikoerper, cholinergic receptor, nicotinic, alpha 7 antikoerper, CHRNA7 antikoerper, LOC100374356 antikoerper, chrna7 antikoerper, Chrna7 antikoerper, LOC100060521 antikoerper

Hintergrund: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.,CHRNA7,CHRNA7-2,NACHRA7,Cancer,Endocrine & Metabolism,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Neurodegenerative Diseases Markers,Other Neurological disorders,Cardiovascular,Angiogenesis,CHRNA7

Molekulargewicht: 11 kDa/56 kDa/59 kDa

Gen-ID: 1139

UniProt: P36544

Pathways: Synaptic Membrane