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anti-Human BMP4 Antikörper:
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Human Polyclonal BMP4 Primary Antibody für IHC (p), ELISA - ABIN544631
Shepherd, Nachtigal: Identification of a putative autocrine bone morphogenetic protein-signaling pathway in human ovarian surface epithelium and ovarian cancer cells. in Endocrinology 2003
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Human Polyclonal BMP4 Primary Antibody für ELISA, WB - ABIN3043490
Fu, Liu, Zhou, Zhou, Sun, Luo, Zhang, Xu: Expansive effects of aorta-gonad-mesonephros-derived stromal cells on hematopoietic stem cells from embryonic stem cells. in Chinese medical journal 2005
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Chicken Polyclonal BMP4 Primary Antibody für IHC, WB - ABIN223638
Ni, Qiu, Rezvan, Kwon, Nam, Son, Visvader, Jo: Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow. in Blood 2010
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Human Monoclonal BMP4 Primary Antibody für ELISA, WB - ABIN968986
Oida, Iimura, Maruoka, Takeda, Sasaki: Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library. in DNA sequence : the journal of DNA sequencing and mapping 1995
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Human Monoclonal BMP4 Primary Antibody für CyTOF, ELISA - ABIN4284902
Scimeca, Antonacci, Toschi, Giannini, Bonfiglio, Buonomo, Pistolese, Tarantino, Bonanno: Breast Osteoblast-like Cells: A Reliable Early Marker for Bone Metastases From Breast Cancer. in Clinical breast cancer 1970
Human Polyclonal BMP4 Primary Antibody für CC, WB - ABIN5518972
Wang, Xue, Zhao, Liu, Ma, Ma: Form-deprivation myopia induces decreased expression of bone morphogenetic protein-2, 5 in guinea pig sclera. in International journal of ophthalmology 2015
Human Monoclonal BMP4 Primary Antibody für - ABIN2715304
Meyers, Gobeske, Bond, Jarrett, Peng, Kessler: Increased bone morphogenetic protein signaling contributes to age-related declines in neurogenesis and cognition. in Neurobiology of aging 2016
Cow (Bovine) Polyclonal BMP4 Primary Antibody für WB - ABIN2789354
Ganti, Hunt, Parapuram, Hunt: Vitreous modulation of gene expression in low-passage human retinal pigment epithelial cells. in Investigative ophthalmology & visual science 2007
Mouse (Murine) Polyclonal BMP4 Primary Antibody für IF (p), IHC (p) - ABIN685642
Wang, Zhao, Wang: Umbilical cord blood cells regulate the differentiation of endogenous neural stem cells in hypoxic ischemic neonatal rats via the hedgehog signaling pathway. in Brain research 2014
The expression of BMP4 and FGF8 corelates well with the proliferative component of the pathologies, indicating a possible role in the pathogenesis and progression of Odontogenic Cyst and Tumors.
We detected a haplotype-based interaction for BMP4 and IRF6 genes for expression of the orofacial cleft phenotype. Although the MDR methods indicate that the effect of interaction between these genes appears to be mild, the presence of specific haplotype combinations conferring a higher risk for NSCL/P reveals the possible combined role of these genes in the pathogenesis of this prevalent birth defect.
Data show that bone morphogenetic protein 4 (BMP4) expression is associated and favored type II macrophage differentiation.
MiR-876-5p suppresses epithelial-mesenchymal transition of lung cancer by directly down-regulating BMP-4.
endothelial BMP4 controls leukocyte recruitment through a VE-cadherin-dependent mechanism and BMP4-induced inflammation might be involved in the pathogenesis of endothelial cell damage following successful resuscitation after cardiac arrest.
Studied serum levels of bone morphogenic protein-4 (BMP-4) and matrix Gla protein (MGP) in patients who were admitted to emergency department with the diagnosis of acute coronary syndrome (ACS) and underwent primary percutaneous coronary intervention. MGP and BMP-4 levels were significantly elevated when compared to subjects with normal coronary arteries.
BMP4 inhibits epithelial-mesenchymal transition of the retinal pigment epithelium.
Potentially functional and tagging SNPs of BMP2 (rs170986, rs1979855, rs1980499, rs235768, rs3178250) and BMP4 (rs17563, rs4898820, rs762642) were genotyped in NSCLC.
BMP4 polymorphic site rs4901474 (T>C) had an effect on hypertension; CC genotype carriers had a 1.48-fold risk for hypertension at the age of 50 years when compared with T-allele carriers
High serum BMP4 levels are associated with postmenopausal osteoporosis.
results indicate that the BMP4 rs17563 variant is likely to confer a protective effect against the occurrence of Non-Syndromic Cleft Lip with or without Cleft Palate in a sample of the southeast Iranian population.
cardiomyocyte (CM) conditioned medium can trigger the recruitment of pro-inflammatory (M1) macrophages, through a mechanism that involves, in part, CM-derived BMP4.
BMP4 participates in the regulation of invasion and migration by EC109/Taxol cells
Bone morphogenetic protein 4 regulates expression of microRNAs miR-494 and miR-126-5p to control endothelial cell function in angiogenesis.
BMP4 expression was significantly increased in HCC tissue, and was correlated with tumor de-differentiation and unfavorable prognosis. BMP4 promoted HCC EMT and was correlated with OXA resistance.
Gene expression profiling showed that MuSK was required for the BMP4-induced expression of a subset of genes in myoblasts, including regulator of G protein signaling 4 (Rgs4).
BMP4 levels are increased dramatically in individuals with impaired glucose tolerance and type 2 diabetes.
The results suggest that selective RNA decay via TGF-beta and BMP4 signaling is critical for specifying the developmental fate of specific human embryonic cell lineages.
Expression of bone morphogenetic protein (BMP) 4, an upstream stimulator of SOX9, was upregulated by CG.
Study shows that BMP4 is overexpressed in hepatocellular carcinoma (HCC) tissues and BMP4-induced ID2/CDKN1B signaling facilitates the proliferation of HCC.
The importance of the BMP4 pathway in endogenous tissue regeneration and offer a potential clinical approach to enhance T cell immunity.
BMP4 and IL7 appear to be involved in the interaction between intestinal epithelial cells and intestinal epithelial cells and in the mechanism underlying intestinal mucosal barrier dysfunction.
Knockdown of BMP4 in pregnant mice at the middle embryonic stage led to aganglionosis.
we demonstrated that the anterior and posterior phenotypes observed in Bmp4 heterozygous animals showed a strong propensity to co-occur, suggesting a common, non-cell autonomous source for these defects.
p73 is required for appropriate BMP-induced mesenchymal-to-epithelial transition during somatic cell reprogramming.
BMP4 inhibits type 2 epithelial cells (AT2s) proliferation, whereas antagonists (follistatin, noggin) promote AT2 self-renewal at the expense of differentiation. Gain- and loss-of-function genetic manipulation reveals that reduced BMP signaling in AT2s after PNX allows self-renewal but reduces differentiation
this study shows that negative autoregulation of BMP4 dependent transcription by SIN3B splicing reveals a role for RBM39
differentiated cells exhibited contracting masses. These results suggest that BMP4-mediated somatic stem cell reprogramming may become an alternative approach for cell therapy
Bmp4 promotes a brown to white-like adipocyte shift.
results suggest that bone morphogenetic protein 4 promotes the generation of male germ cells from induced pluripotent stem (iPS) cells
These results suggest how BMP4 regulates adipocyte recruitment in subcutaneous (SC) white adipose tissue, and thus promote its beneficial metabolic effects.
RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells
Expression of Bmp4 in the ureteric mesenchyme depends on HH signaling and Foxf1, and that exogenous BMP4 rescued cell proliferation and epithelial differentiation in ureters with abrogated HH signaling or FOXF1 function.
the effect of titanium (Ti) with nanotopography (Nano) on the endogenous expression of BMP-2 and BMP-4 and the relevance of this process to the nanotopography-induced osteoblast differentiation.
These data indicate that Foxc1 expression is regulated by BMP4 and FOXC1 functions in the commitment of progenitor cells to the osteoblast fate and its expression is reduced when differentiation proceeds.
Phosphorylated Smad1/5/8/9 specifically bound to the BREs of Smad8/9 gene. The present study reveals that Smad8/9 is a unique R-Smad regulated through the BMP pathway at the mRNA level.
Treatment of ES cells with TPO induced the autocrine production of BMP4 with concomitant upregulation of the BMP receptor BMPR1A, phosphorylation of SMAD1, 5, 8, and activation of specific BMP4 target genes; this was mediated by TPO-dependent binding of transcription factor HIF-1alpha to the BMP4 gene promoter.
Data suggest that ovarian Bmp4 levels are significantly decreased in a mouse model of polycystic ovary syndrome with hyperandrogenism; androgens inhibited Bmp4 expression via activation of androgen receptors; Smad4 signaling rather than p38 MAPK pathway regulates androgen and estrogen formation.
Structures of Bmp2a, Bmp2b, Bmp4 and Bmp16 were found to be remarkably similar; with residues involved in receptor binding being highly conserved.
FGF signaling in establishment of the developmental hematopoietic stem cell niche occurs via inhibition of bmp4 transcription, and activation of bmp antagonists, nog2 and grem1a.
we identify a previously unappreciated role for the Nodal-transcription factor FoxH1 in mediating cell responsiveness to Bmp further linking the control of these two pathways in the heart
Results show that BMP4 down-regulates fshr while up-regulating lhr expression.
These data reveal a novel role for LRP1 in the regulation of Bmp4 signaling by regulating receptor complex endocytosis.
Id2a and Bmp4 misexpression resulted in similar ectomesenchyme defects;misexpression of Bmp4 in migrating Cranial neural crest cells inhibits ectomesenchyme formation.
Wnt/beta-catenin signaling is both sufficient and required for the induction of BMP4 and Tbx2b expression in the AVC
identify Npnt as a novel upstream regulator of Bmp4-Has2 signaling that plays a crucial role in AV canal differentiation
immature AVC expansion in wkm mutants is rescued by depleting Bmp4, indicating that Tmem2 restricts bmp4 expression to delimit the AVC primordium during cardiac development
Elimination of function of bmp2b and bmp4 singly and in combination did not prevent the formation of mature, attached teeth.
BMP has a role in regulation of myogenesis in zebrafish
Tbx5a confers anterior lateral plate mesodermal cells the competence to respond to Bmp signals and initiate proepicardial organ development.
GATA-6 maintains BMP-4 expression during cardiomyocyte precursor maturation.
The 7.5-kb BMP4 promoter/proximal upstream region specifically contains regulatory elements for BMP4 expression in the heart, while regulatory elements for other endogenous BMP4-expressing tissues may reside in more distal regions and/or in introns.
Expressed in Kupffer's vesicle; restricted knock down of bmp4 in this structure results in left-right patterning defects.
BMP4 is required during the later phase of BMP signaling for the specification of ventroposterior cell fates
Data indicate that BMP4 plays an important role in the development of protrusions to form semicircular canals.
precise amount and/or timing of Wnt/beta-catenin signaling is required for proper heart tube formation and cardiac looping
TCDD altered the localized expression of mRNAs bmp4 and nothch1b normally associated with developing heart valves in zebrafish.
These results illustrate a role for Bmp4 in the proliferation and timely differentiation of axial tissue after dorsoventral axis specification.
Data indicate that bone morphogenetic protein (BMP) signaling is essential for erythroid differentiation, and in the absence of BMP signaling, precursor cells adopt an endothelial cell (EC) fate.
Osr1/Osr2 normally repress bmp4 expression in the lateral plate mesoderm prior to respiratory specification.
The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4.
PIAS proteins have differential ability to regulate signals from the growth factors activin, bone morphogenetic protein 4 (BMP4), and Wnt8.
Data show that PV.1A undergoes combinatorial regulation during early Xenopus development as both the direct target of BMP-4 signaling and as the direct and indirect target of positive and negative regulatory factors.
BMP inhibition is sufficient for neural induction in vivo, and that in the absence of ventral BMPs, Spemann organizer signals are not required for brain formation.
Data suggest that the feedback inhibitors BAMBI, SMAD6, and SMAD7 expand the dynamic BMP4 signaling range essential for proper embryonic patterning and reduce interindividual phenotypic and molecular variability in Xenopus embryos.
limits homeobox gene expression in the organiser/non-organiser direction
X-epilectin expression is down-regulated by Noggin and tBR and that this effect is inhibited by BMP4 over-expression
BMP4-dependent expression of Xenopus Grainyhead-like 1 has a critical role in epidermal differentiation
XBP1 interacts with BMP-4 and Xvent-2B promoters.
connective tissue-specific expression of BMP-4 mRNA is up-regulated by sonic hedgehog (Shh)
An intermediate level of BMP4 signaling is required to induce neural plate border fates.
Bmp antagonists and morpholinos designed against Bmp4, Bmp2, and Bmp7 demonstrate that Bmp signaling is critical for ventral, but not dorsoanterior endoderm formation
CV2/Chordin interaction may help coordinate bone morphogenetic protein (BMP) diffusion to the ventral side of the embryo, ensuring that BMPs liberated from Chordin inhibition by tolloid proteolysis cause peak signaling levels.
BMP4 inhibits Tolloid enzyme activity noncompetitively
High BMP4 expression is associated with cystic ovarian disease.
Bone morphogenetic protein 4 and retinoic acid trigger bovine VASA homolog expression in differentiating bovine induced pluripotent stem cells.
The BMP2/4 ligand and receptor system presides within bovine trophectoderm prior to uterine attachment. BMP4 negatively impacts CT1 cell growth
BMP4 during maturation increased the proportion of Oct-4 positive cells in parthenogenic embryos. BMP4 is implicated in bovine oocytes maturation and embryo development.
analysis of polymorphic CA microsatellites in the third exon of the bovine BMP4 gene
concluded that a bone morphogenetic protein (BMP)-signaling system, consisting of BMP2, BMP4, type II and I receptors, is present in bovine antral follicles and plays a role in development and functioning of follicles rather than in oocyte maturation
Data report that BMP-7 suppresses granulosa cell apoptosis by inhibiting the release of caspase-activated DNase (CAD) via a mechanism which does not appear to be associated with the mitochondrial pathway, whereas BMP-4 inhibits the release of CAD.
Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein.
The TM-induced characteristic changes in the expression pattern of Hoxa11 and Bmp4 on GDs 10 and/or 11 were not noted.
BMP4 is expressed peripherally in hypoblast and epiblast and in the mesoderm at the posterior pole of the embryonic disc.
Data show that BMP-2, BMP-4, and BMP-7, noggin, and chordin were colocalized in rimming osteoblasts, osteoclasts, and chondrocytes.
Both of the adenovirus-containing bone morphogenetic protein transduced MSCs expressed BMP4 mRNA and protein and underwent osteogenic differentiation.
BMP4 signaling plays a role in the regulation of terminal differentiation of primary equine trophoblast cells via activation of the SMAD1/5 pathway
paracrine signals from the embryo, represented by FGF4 and BMP4, induce a response in the trophoblast prior to the extensive elongation.
The structure of porcine BMP4 gene is highly conservative with other mammalian BMP4 genes, but some differences may be present in the regulation of gene expression.
Altered shear stress stimulates upregulation of endothelial VCAM-1 and ICAM-1 in a BMP-4- and TGF-beta1-dependent pathway.
A microsatellite (ACn) was identified in the 3' UTR of BMP4 gene.Prolificacy associated microsatellite (AC19) was detected in Indian goats.
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
, bone morphogenetic protein 2B
, bone morphogenetic protein-4
, bone morphogenetic protein 4
, bone morphogenetic protein 4, isoform 3
, Bone morphogenetic protein 4
, bone morphogenetic protein 4-like