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anti-Rat (Rattus) SALL4 Antikörper:
anti-Mouse (Murine) SALL4 Antikörper:
anti-Human SALL4 Antikörper:
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Human Monoclonal SALL4 Primary Antibody für IHC (p), ELISA - ABIN566099
Cauffman, De Rycke, Sermon, Liebaers, Van de Velde: Markers that define stemness in ESC are unable to identify the totipotent cells in human preimplantation embryos. in Human reproduction (Oxford, England) 2008
Show all 17 Pubmed References
Human Polyclonal SALL4 Primary Antibody für ELISA, WB - ABIN4369825
Paradisi, Arias: IVIC syndrome is caused by a c.2607delA mutation in the SALL4 locus. in American journal of medical genetics. Part A 2007
Show all 3 Pubmed References
Rat (Rattus) Polyclonal SALL4 Primary Antibody für ELISA, WB - ABIN253101
Wang, Rao, Chu, Shen, Levasseur, Theunissen, Orkin: A protein interaction network for pluripotency of embryonic stem cells. in Nature 2006
Human Polyclonal SALL4 Primary Antibody für WB - ABIN388303
Yang, Chai, Liu, Fink, Lin, Silberstein, Amin, Ward, Ma: Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells. in Proceedings of the National Academy of Sciences of the United States of America 2007
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Data show that both sall1 (zeige SALL1 Antikörper) and sall4 act to repress pou5f3 (oct4)family gene expression in the neural plate, thereby allowing vertebrate neural development to proceed.
These results suggest that Sall4, activated by posteriorizing signals, represses the pou5f3 genes to provide a permissive environment.
SAL family member (XlSALL4) is expressed at the right place and time to play a role regulating both digit identity along the anterior/posterior axis and epimorphic limb regeneration
Sall4 expression expression in chemosensory cells implicates this transcription factor in the development and renewal of taste epithelia in zebrafish.
Sall gene family redundancy and tbx5 (zeige TBX5 Antikörper) offer explanations for the similarity of individuals with Okihiro syndrome and Holt-Oram syndrome limb defects
Study propose a model whereby enhancer binding by Sall4 and other pluripotency-associated transcription factors is responsible for maintaining the balance between transcriptional programmes in pluripotent cells.
SALL4 has a negative impact in DNA damage repair, and support the model of dual functional properties of SALL4 in leukemogenesis through inhibiting DNA damage repair and promoting cell survival.
these data reveal the full profile of PLZF (zeige ZBTB16 Antikörper) and SALL4 regulatory targets in undifferentiated spermatogonia.
study explores a pivotal role of Sall4 in regulating epigenetic maturation of mouse oocytes.
JARID2 (zeige JARID2 Antikörper) physically interacts with ESRRB, SALL4A, and PRDM14 (zeige PRDM14 Antikörper)
As SALL4A is known to impair ZBTB16 (zeige ZBTB16 Antikörper)-mediated Kit repression , our study provides novel insights into the molecular mechanism by which ATRA could control KIT expression, and thereby the differentiation of Aal into A1 spermatogonia in vivo.
In differentiated ESCs (zeige NR2E3 Antikörper), Sall4 bound to these somatic cell program gene loci, which are reportedly occupied by Prdm1 (zeige PRDM1 Antikörper) in embryonic carcinoma cells.
This study identified a critical role of the Sall4-Gli3 (zeige GLI3 Antikörper) system at the early steps of limb development for proper development of the appendicular skeletal elements.
Sall4 also interacts with Baf60a (zeige SMARCD1 Antikörper), a member of the SWI (zeige SMARCA1 Antikörper)/SNF (zeige SNRPA Antikörper) (switch/sucrose nonfermentable) ATP-dependent chromatin-remodeling complex, which is responsible for recruiting Sall4 to the site of DNA DSB damage.
SALL4b is the major isoform in hematopoietic stem cells. Overexpression of either isoform impairs hematopoietic colony formation. Lineage-negative bone marrow overexpressing SALL4b fails to engraft. SALL4a or SALL4b overexpression impairs hematopoiesis.
SALL4 overexpression is associated with neoplasms.
Findings indicate that long-term exposure to IM results in dysregulation of stem cell renewal-regulatory Hippo (MST1 (zeige MST1 Antikörper)/2)/YAP (zeige YAP1 Antikörper) signaling, and that inhibition of miR (zeige MLXIP Antikörper)-181a using a microRNA sponge inhibitor resulted in decreased transcription of SOX2 (zeige SOX2 Antikörper) and SALL4.
Study showed that SALL4 was overexpressed in a majority of human esophageal squamous cell carcinoma (ESCC) tissues and that aberrantly activated SALL4 may contribute to esophageal tumorigenesis by promoting malignant proliferation and inhibiting cell apoptosis, regulating esophageal squamous cell migration, invasion and cell cycle.
Data show that SALL4 promotes the expression of Glut1 (zeige SLC2A1 Antikörper) and open chromatin through a HP1alpha (zeige CBX5 Antikörper)-dependent mechanism.
Our report is the first description of structural eye defects associated with two missense variants in SALL4 inherited in trans; the absence of reported findings in both parents suggests that both sequence variants are hypomorphic mutations and that both are needed for the ocular phenotype.
our study showed that SALL4 plays an important role in regulating the proliferation, migration, and invasion of osteosarcoma cells.
The SALL4 - integrin alpha6 - integrin beta1 network promotes cell migration for metastasis via activation of focal adhesion dynamics in basal-like breast cancer cells.
Coexpression of SALL4 with HDAC1 (zeige HDAC1 Antikörper) and/or HDAC2 (zeige HDAC2 Antikörper) was associated with PTEN (zeige PTEN Antikörper) underexpression and a poor prognosis in hepatocellular carcinoma.
demethylation of CpGs located within OCT4 (zeige POU5F1 Antikörper) and STAT3 (zeige STAT3 Antikörper) cis (zeige CISH Antikörper)-acting elements, downstream of SALL4 TSS (zeige RPL38 Antikörper), enables OCT4 (zeige POU5F1 Antikörper) and STAT3 (zeige STAT3 Antikörper) binding, recruitment of BRG1 (zeige SMARCA4 Antikörper), and enhanced RNA polymerase II elongation and SALL4 transcription
The protein encoded by this gene may be a zinc finger transcription factor. Defects in this gene are a cause of Duane-radial ray syndrome (DRRS).
sal-like 4 (Drosophila)
, sal-like protein 4-like
, sal-like 4
, zinc finger transcription factor SALL4 a
, sal-like protein 4
, zinc finger protein SALL4
, zinc finger protein 797