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anti-Human HES5 Antikörper:
anti-Mouse (Murine) HES5 Antikörper:
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Over-expression of her12, her15 or her7 disrupts cyclic gene expression and somite border formation, and structure function analysis of Her7 indicates that DNA binding, but not Groucho-recruitment seems to be important in this process.
HES5 might contribute to the proliferation of non-small cell lung cancer by STAT3 (zeige STAT3 Antikörper) signaling.
that suppression of the HES5 leading to inhibition of proliferation may be one of the mechanisms against Hepatocellular carcinoma
HES5 silencing is an early and recurrent change in prostate tumourigenesis
these data identify HES5 as a key mediator of the Wnt-3a (zeige WNT3A Antikörper) proneurogenic effect occurring independently of the classical Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling cascade thus further deciphering crosstalk mechanisms of Wnt (zeige WNT2 Antikörper) and Notch (zeige NOTCH1 Antikörper) signaling pathways regulating cell fate
the downstream Notch (zeige NOTCH1 Antikörper) signalling effector HES5 directly represses transcription of the E3 ligase Fbw7beta.
Notch3 (zeige NOTCH3 Antikörper) and Hes5 are hypermethylated in human B cell acute lymphoblastic leukemia (ALL).
Hes5 overactivation is associated with cell differentiation, thereby resulting in uterine carcinogenesis.
In this study, HES 5 transcription factor was detected in the lining epithelium of human periapical cysts with limited inflammation, showing Notch (zeige NOTCH1 Antikörper) pathway activation in those cells.
The expression of HES5 in adenocarcinoma was significantly higher than those in adenoma and normal control
For marking and purifying neural stem cells to ascertain whether differences exist, we generated transgenic mice using promoters from Hes (zeige RRBP1 Antikörper) genes (pHes1 or pHes5) to drive expression of destabilized enhanced green fluorescent protein.
Sox2 (zeige SOX2 Antikörper) activity is crucial for the induction of the neural progenitor gene Hes5 and for subsequent differentiation of the neuronal lineage.
Hes5 regulates the transition timing between phases for specification of neocortical neurons and between neurogenesis and gliogenesis.
the RBPjkappa-dependent Notch (zeige NOTCH1 Antikörper) targets HES1 and HES5 suppress chondrogenesis and promote the onset of chondrocyte hypertrophy.
This study demonstrated that Hes1 and Hes5 modulate not only maintenance of progenitor cells but also pituicyte versus neuron fate specification during neurohypophysis development.
delivery of siRNA to Hes1 and Hes5 using a transfection reagent or siRNA to Hes1 encapsulated within nanoparticles increased hair cell numbers in non-toxin treated organotypic cultures of cochleae and maculae
The transcription and expression patterns of Notch (zeige NOTCH1 Antikörper) pathway components (Notch 1 (zeige NOTCH1 Antikörper)-3, Delta1 and 4, Jagged1 (zeige JAG1 Antikörper)) and effectors (Hes1, Hes2 (zeige HES2 Antikörper), Hes5 and Nrarp (zeige NRARP Antikörper)) were evaluated in the mouse testis
Hes1 and Hes5 regulate vascular remodeling and arterial fate specification of endothelial cells in the development of the brain; they are critical transducers of Notch (zeige NOTCH1 Antikörper) signals in brain vascular development.
Data demonstrate that Hes5 levels in the utricle decreased after the application of siRNA and that the number of hair cells in these utricles was significantly larger than following control treatment.
Epigenetic silencing of Hes5 leads to neuronal differentiation despite active Notch (zeige NOTCH1 Antikörper) signaling.
This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer.
hairy and enhancer of split 5
, transcription factor HES-5
, Transcription factor HES-5
, class B basic helix-loop-helix protein 38