CACNA1D Proteine (CACNA1D)

Bezeichnung:: Calcium Channel, Voltage-Dependent, L Type, alpha 1D Subunit Proteine (CACNA1D)

Auf www.antikoerper-online.de finden Sie aktuell 8 Calcium Channel, Voltage-Dependent, L Type, alpha 1D Subunit (CACNA1D) Proteine von 1 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CACNA1D Antikörper (132) und CACNA1D Kits (10) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 150 CACNA1D Produkte verfügbar.

Synonyme:: 8430418G19Rik, C79217, ca(v)1.3, CACH3, CACN4, cacna1d, Cacnl1a2, Cav1.3, cav1.3a, Cchl1a, Cchl1a2, D-LTCC, isl, SANDD, si:dz136d19.3, si:dz223c6.1

alle Proteine anzeigen	Gen	GeneID	UniProt
	CACNA1D	776	Q01668
Ratte CACNA1D	CACNA1D	29716	P27732
	CACNA1D	12289	Q99246
Weitere Synonyme anzeigen

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Verknüpfte Pathways mit CACNA1D Proteine

Sensory Perception of Sound

Weitere Produktkategorien zu CACNA1D Protein

Weitere Proteine zu CACNA1D Interaktionspartnern

Zebrafish Calcium Channel, Voltage-Dependent, L Type, alpha 1D Subunit (CACNA1D) Interaktionspartner

Mutations in zebrafish cav1.3a underlie the auditory-vestibular defects of gemini (gem) circler mutants. gem mutant hair cells display normal cell viability, afferent synaptogenesis, and peripheral innervation, yet exhibit reduced extracellular potentials

Cow (Bovine) Calcium Channel, Voltage-Dependent, L Type, alpha 1D Subunit (CACNA1D) Interaktionspartner

new information on the hypothalamic expression of alpha1A and alpha1D subunits during development in a mammal with a long gestation period and a large and convoluted brain.

Human Calcium Channel, Voltage-Dependent, L Type, alpha 1D Subunit (CACNA1D) Interaktionspartner

Data suggest that p.G403D mutation in CACNA1D causes persistent hyperinsulinaemic hypoglycaemia with heart defects (presenting as aortic valve insufficiency) and severe neuromuscular disease (presenting as hypotonia); this study involves DNA mutational analysis in one patient plus 2 unrelated patients. [CASE REPORT]
These results provide the evidence of a direct regulatory role of Snapin (zeige SNAPIN Proteine) on Cav1.3 channels in atrial myocytes.
Study used structure modeling and MD simulations to predict omega-currents in CaV1.1 (zeige CACNA1S Proteine) and CaV1.3 channel VSDs when one of the first three S4 gating charges harbors a disease-causing mutation. Using site-directed mutagenesis and electrophysiology, experimentally confirmed that the mutation of R3 charge to His in VSD III of CaV1.3 channels results in an omega-current at hyperpolarizing potentials.
CACNA1D mutations predominate in small zona glomerulosa (ZG)-like Aldosterone-producing Adenomas.
The CACNA1C (zeige CACNA1C Proteine)-L762F mutation is associated with development of long QT syndrome through slower channel inactivation and increased sustained and window current. Timothy syndrome -associated mutations localize to specific areas of CACNA1C (zeige CACNA1C Proteine) and are associated with a younger age at presentation, higher QTc, and 2:1 AV block than isolated LQTS-associated mutations.
Mutations in CACNA1D cause the excessive autonomous aldosterone secretion of Aldosterone-producing Adenomas.
While the relative contribution of Cav1.3 to intestinal Ca(2 (zeige CA2 Proteine)+) absorption and its value as a therapeutic target remain to be established, we postulate that Cav1.3 downregulation in IBD may contribute to the negative systemic Ca(2 (zeige CA2 Proteine)+) balance, to increased bone resorption, and to reduced bone mineral density in IBD patients.
E2 upregulated the expression of Cav1.3 for Ca2+ influx to promote the expression of p-ERK1/2 for cell proliferation in breast cancer cells
LRP1B (zeige LRP1B Proteine), BRD2 (zeige BRD2 Proteine) and CACNA1D are new candidate genes in fetal metabolic programming of newborns exposed to maternal hyperglycemia.
CACNA1D might not be a risk gene for SCZ in Han Chinese population, which add to the current state of knowledge regarding the susceptibility of CACNA1D to schizophrenia.

Mouse (Murine) Calcium Channel, Voltage-Dependent, L Type, alpha 1D Subunit (CACNA1D) Interaktionspartner

These results provide the evidence of a direct regulatory role of Snapin (zeige SNAPIN Proteine) on Cav1.3 channels in atrial myocytes.
Ca(2 (zeige CA2 Proteine)+) entry serves critical cellular functions in virtually every cell type, and appropriate regulation of Ca(2 (zeige CA2 Proteine)+) in neurons is essential for proper function.
Auditory inner hair cells (IHCs) encode sounds into nerve impulses through fast and indefatigable Ca(2 (zeige CA2 Proteine)+)-dependent exocytosis at their ribbon synapses. We show that this synaptic process involves long and short C-terminal isoforms of the Cav1.3 Ca(2 (zeige CA2 Proteine)+) channel that differ in the kinetics of their Ca(2 (zeige CA2 Proteine)+)-dependent inactivation and their relative sensitivity to the l-type Ca(2 (zeige CA2 Proteine)+) channel blocker nifedipine.
alpha1D Ca and SK4 channels are coupled in the atria, and deletion of alpha1D leads to decreased SK4 mRNA and BNP secretion providing evidence for a novel role of alpha1D in atrial endocrine function
beta-Adrenergic stimulation enhanced pacemaking of both genotypes, though, Cav1.3(-/-) sino-atrial node cells remained slower than wild type
implicating Cav1.3 as an essential element for hippocampus-associated cognitive functions
Studies indicate the function of L-type calcium channels Cav1.3 in chromaffin cells.
Data suggest that the ion channels CaV1.3, bestrophin-1 (zeige BEST1 Proteine) and maxiK (zeige KCNMA1 Proteine) were identified as players in the regulation of photoreceptor outer segments (POS) phagocytosis by the retinal pigment epithelium (RPE (zeige RPE Proteine)).
Cp8 is a new of Cav1.2 (zeige CACNA1C Proteine) and Cav1.3 channel activators.
RIM2alpha and RIM2beta promote a large complement of synaptic CaV1.3 Ca(2 (zeige CA2 Proteine)+) channels at inner hair cell presynaptic active zones and are required for normal hearing.

CACNA1D Protein Überblick

Protein Überblick

Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with CACNA1D

calcium channel, voltage-dependent, L type, alpha 1D subunit, a (cacna1da)
calcium voltage-gated channel subunit alpha1 D (CACNA1D)
calcium channel, voltage-dependent, L type, alpha 1D subunit (cacna1d)
calcium channel, voltage-dependent, L type, alpha 1D subunit L homeolog (cacna1d.L)
calcium voltage-gated channel subunit alpha1 D (Cacna1d)
calcium channel, voltage-dependent, L type, alpha 1D subunit (Cacna1d)

8430418G19Rik Protein
C79217 Protein
ca(v)1.3 Protein
CACH3 Protein
CACN4 Protein
cacna1d Protein
Cacnl1a2 Protein
Cav1.3 Protein
cav1.3a Protein
Cchl1a Protein
Cchl1a2 Protein
D-LTCC Protein
isl Protein
SANDD Protein
si:dz136d19.3 Protein
si:dz223c6.1 Protein

Bezeichner auf Proteinebene für CACNA1D

, , , , , , , , , , , , , , , , , , , , , , , L-type calcium channel pore subunit isoform 1.3a gem gemini voltage-dependent L-type calcium channel subunit alpha-1D voltage-gated calcium channel alpha 1D subunit calcium channel, voltage-dependent, L type, alpha 1D subunit voltage-gated calcium channel subunit Cav1.3 calcium channel voltage-dependent L type Cav1.3, alpha 1d subunit voltage-dependent L-type calcium channel subunit alpha-1D-like calcium channel, L type, alpha-1 polypeptide calcium channel, neuroendocrine/brain-type, alpha 1 subunit voltage-gated calcium channel alpha 1 subunit voltage-gated calcium channel alpha subunit Cav1.3 CaV1.3alpha1 RBD brain class D calcium channel alpha-1 subunit voltage-dependent calcium channel subunit alpha1D voltage-gated calcium channel pore forming subunit CaV1.3alpha1 IVS3-IVS4 extracellular linker voltage-gated calcium channel subunit alpha Cav1.3 Cav1.3alpha1 alpha 1 E CHCACHA1D L-type voltage-gated calcium channel alpha1D subunit ChCaChA1D

GENE ID	SPEZIES
403310	Danio rerio
408013	Bos taurus
460447	Pan troglodytes
484724	Canis lupus familiaris
780391	Xenopus (Silurana) tropicalis
100135991	Oncorhynchus mykiss
100462912	Xenopus laevis
100511102	Sus scrofa
776	Homo sapiens
29716	Rattus norvegicus
12289	Mus musculus
395895	Gallus gallus

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