Maus anti-Human IgG4 Antikörper

Produktnummer ABIN952860

Produktdetails

Target: IgG4

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Supernatant

Klon: MRQ-44

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Handhabung: Monoclonal antibodies should not be stored at a temperature below -25 °C due to the aggregation effect of the protein.

Antigendetails

Target: IgG4

Andere Bezeichnung: Immunoglobulin G4 (IgG4) (IgG4 Produkte)

Substanzklasse: Antibody

Hintergrund: IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells. As these patients tend to respond favorably to steroid treatment, it is important to recognize this entity and differentiate it from such mimics as lymphoma. Clinical manifestations are apparent in the pancreas, bile duct, gallbladder, lacrimal gland, salivary gland, retroperitoneum, kidney, lung, breast, thyroid, and prostate. Immunohistochemical analyses in the case of IgG4-related sclerosing disease not only exhibits significantly more IgG4-positive plasma cells in affected tissues but also significantly higher IgG4/ IgG ratios (typically > 30 % ).Synonyms: Human Immunoglobulin G4