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Human VEGFC Protein expressed in Escherichia coli (E. coli) - ABIN413872
Werchau, Toberer, Enk, Dammann, Helmbold: Merkel cell carcinoma induces lymphatic microvessel formation. in Journal of the American Academy of Dermatology 2011
Show all 6 Pubmed References
These findings thus underscore a role for posterior cardinal (zeige CARD8 Proteine) vein and VegfC in patterning the head kidney prior to organ assembly and function.
Vegfc acts through ERK (zeige MAPK1 Proteine) to induce sprouting and differentiation of trunk lymphatic progenitors.
data not only reveal a non-canonical function of Mt2 (zeige MT2 Proteine) in angiogenesis, but also propose Mt2 (zeige MT2 Proteine) as a novel regulator of vegfc expression.
Vegfc signaling increases mafba (zeige MAFB Proteine) expression to control downstream transcription
Vegfc is dispensable for facial lymphatic sprouting but not for the complete development of the facial lymphatic network.
In the embryo, phenotypes driven by increased Vegfc are suppressed in the absence of Ccbe1 (zeige CCBE1 Proteine), and Vegfc-driven sprouting is enhanced by local Ccbe1 (zeige CCBE1 Proteine) overexpression. Moreover, Vegfc- and Vegfr3 (zeige FLT4 Proteine)-dependent Erk (zeige MAPK1 Proteine) signaling is impaired in the absence of Ccbe1 (zeige CCBE1 Proteine).
Vegfc has an essential role in lymphangiogenesis [review]
The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 (zeige FLT4 Proteine) signaling in zebrafish.
Vegfc acts in two distinct modes during development: as a paracrine factor secreted from arteries to guide closely associated lymphatic vasculature and as an autocrine factor to drive migratory persistence during angiogenesis.
Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.
VEGF-C and VEGF (zeige VEGFA Proteine)-C156S genes have roles in the pro-lymphangiogenic growth factor therapy of lymphedema
Transcription of the vascular endothelial growth factor C gene (VEGF-C) and translation of the corresponding protein were significantly up-regulated in swine umbilical vein endothelial cells with classical swine fever virus acute infection.
No difference in bioactivity was detected between porcine relaxin-1 (zeige RLN1 Proteine) and recombinant human relaxin-2 (zeige RLN1 Proteine) in either mice or rats.
During progressive ischemia, functional and metabolic benefits of intramyocardial VEGF-C gene transfer were apparent. VEGF-C-induced collateral formation occurred at the site of gene transfer
The mutation induced skipping of exon 2 of VEGFC resulting in a frameshift and the introduction of a premature stop codon (p.Ala50ValfsTer18). The mutation leads to a loss of the entire VEGF (zeige VEGFA Proteine)-homology domain and the C-terminus.
VEGFR-3 and CAV3 expression demonstrated immunohistochemically in SMCs of the tunica media of SV grafts predicted their early restenosis in triple-vessel CAD patients. CAV2 protein expression in SMCs of ITA grafts indicated the risk of early graft failure both in double-vessel and triple-vessel CAD subjects.
VEGF-C expression and secretion in gastric cancer is downregulated by kallistatin (zeige SERPINA4 Proteine).
Concomitant high expression of survivin and VEGF-C is closely associated with LNM status of PTC (zeige F9 Proteine) patients, which suggests their cooperation in the metastatic process.
TNFSF15 (zeige TNFSF15 Proteine), a cytokine mainly produced by blood endothelial cells, facilitates tumor lymphangiogenesis by upregulating VEGFC expression in A549 cells.
SPARC (zeige SPARC Proteine) expression was inversely associated with the degree of malignancy and it had a negative correlation with VEGF-C and VEGF-D (zeige Figf Proteine) expression. Results suggest SPARC (zeige SPARC Proteine) might function as a tumor suppressor inhibiting angiogenesis and lymphangiogenesis in ovarian cancer by reducing the expression of VEGF-C and VEGF-D (zeige Figf Proteine).
VEGF-A/VEGF (zeige VEGFA Proteine)-C analysis showed higher positivity in metastatic nodes and higher positivity in the surrounding negative nodes from positive cases in comparison with nonmetastatic patients.
this study shows that decidual NK cells facilitate the interaction between trophoblastic and endothelial cells via VEGF-C and HGF (zeige HGF Proteine)
Lymphangiogenesis during tubulointerstitial fib (zeige CTGF Proteine)rosis to be associated with increased expression of CTGF and VEGF-C in human obstructed nephropathy as well as in diabetic kidney disease. vitro, CTGF induced VEGF-C production in HK-2 cells, while CTGF siRNA suppressed transforming growth factor beta1-induced VEGF-C upregulation.
Smad4 (zeige SMAD4 Proteine) expression negatively correlated with VEGF-A (zeige VEGFA Proteine) and VEGF-C in colon cancer
As shown in mouse model of kidney fibrosis CTGF (zeige CTGF Proteine) is significantly involved in fibrosis-associated renal lymphangiogenesis through regulation of, and direct interaction with, VEGF-C.
Fluid shear stress regulates vascular remodeling via VEGFR-3 (zeige FLT4 Proteine) activation, independently of its ligand, VEGF-C, in the uterus during pregnancy.
A novel heparin conjugate (LHbisD4) is shown to prevent lymphangiogenesis by blocking the vascular endothelial growth factor C (VEGF-C) induced signaling pathway.
lymphangiogenesis is regulated by two distinct proteolytic mechanisms of ligand activation: one in which VEGFC activation by ADAMTS3 (zeige Adamts2 Proteine) and CCBE1 (zeige CCBE1 Proteine) spatially and temporally patterns developing lymphatics, and one in which VEGFD (zeige Figf Proteine) activation by a distinct proteolytic mechanism may be stimulated during inflammatory lymphatic growth
These results reveal an unexpected role for VEGF-C, a major lymphangiogenic growth factor, in the transition to fetal liver erythropoiesis.
Results suggest that interleukin-6 (IL-6 (zeige IL6 Proteine)) increases VEGF-C induction and lymphangiogenesis may involve, at least in part, Src (zeige SRC Proteine)-FAK (zeige PTK2 Proteine)-STAT3 (zeige STAT3 Proteine) cascade in lymphatic endothelial cells (LECs).
Data show that heparanase-1 (HPA-1 (zeige HPSE Proteine)) induced shedding of heparan sulfate chain from syndecan-1 (SDC-1 (zeige SDC1 Proteine)) facilitated the release of vascular endothelial growth factor C (VEGF-C) from SDC-1 (zeige SDC1 Proteine)/VEGF-C complex into the medium of hepatocarcinoma cell.
Data show that in the MCF-7 breast cancer cell line, only MT1X (zeige MT1X Proteine) metallothioneins (MTs (zeige NEU2 Proteine)) positively correlated with vascular endothelial growth factor C (VEGFC).
The findings in this study strongly suggest the following: i) that VEGF-C promotes the proliferative activity and migratory ability of mesenchymal stem cell ; and ii) VEGF-C and Tgfb (zeige TGFB1 Proteine) reciprocally regulate mesenchymal stem cell commitment to differentiation into lymphatic endothelial or osteoblastic phenotypes, respectively.
The authors show that VEGF-C is necessary for perinatal lymphangiogenesis, but required for adult lymphatic vessel maintenance only in the intestine.
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.
vascular endothelial growth factor C
, vascular endothelial growth factor c
, FLT4 ligand DHM
, vascular endothelial growth factor-related protein
, flt4 ligand
, vascular endothelial growth factor C isoform 129
, vascular endothelial growth factor C isoform 184