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Vascular Endothelial Growth Factor C (VEGFC) (AA 103-227) protein (His tag) Protein

VEGFC Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Pubmed (1 reference)
Produktnummer ABIN2181912
$275.00
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Lieferung in 2 bis 3 Werktagen
  • Target Alle VEGFC Proteine anzeigen
    VEGFC
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 103-227
    Spezies
    • 13
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 14
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses VEGFC Protein ist gelabelt mit His tag.
    Sequenz
    AA 103-227
    Produktmerkmale
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15 kDa. The protein migrates as 18-23 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
  • de Guzman, Rabbany: "PEG-Immobilized Keratin for Protein Drug Sequestration and pH-Mediated Delivery." in: Journal of drug delivery, Vol. 2016, pp. 7843951, (2016) (PubMed).

  • Target
    VEGFC
    Andere Bezeichnung
    VEGF-C (VEGFC Produkte)
    Synonyme
    VEGFC, vegf-c, xvegf-c, Flt4-L, VRP, AW228853, VEGF-C, vascular endothelial growth factor c, vascular endothelial growth factor C, vascular endothelial growth factor C S homeolog, vegfc, VEGFC, vegfc.S, Vegfc
    Hintergrund
    Vascular endothelial growth factor C is also known as VEGFC, Flt4-L and VRP, it contains the C-terminal propeptide which has an unusual structure with tandemly repeated cysteine-rich motifs. Upon biosynthesis, VEGFC is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGFC is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis, lymphangiogenesis and endothelial cell growth and survival, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. The structure and function of this protein is similar to those of vascular endothelial growth factor D (VEGF-D). VEGFC may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Overexpression of VEGF-C causes lymphatics to enlarge possibly facilitates metastasis.
    Molekulargewicht
    14.9 kDa
    Pathways
    RTK Signalweg, Signaling Events mediated by VEGFR1 and VEGFR2
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