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Timelapse analysis of individual cardiomyocyte trajectories reveals misdirected cells in zebrafish pdgfra (zeige PDGFRA Proteine) mutants, suggesting that PDGF (zeige PDGFA Proteine) signaling steers cardiomyocytes toward the midline during cardiac fusion. Intriguingly, the ligand pdgfaa is expressed in the endoderm medial to the pdgfra (zeige PDGFRA Proteine)-expressing myocardial precursors.
This study demonstrates the involvement of VEGF signaling in regulating sustained liver injuries after acute alcohol exposure.
we determined that radial glia control this process via the Vegf decoy receptor sFlt1 (zeige FLT1 Proteine): sflt1 (zeige FLT1 Proteine) mutants exhibit the venous over-sprouting observed in radial glia-ablated larvae, and sFlt1 (zeige FLT1 Proteine) overexpression rescues it. Genetic mosaic analyses show that sFlt1 (zeige FLT1 Proteine) function in trunk endothelial cells can limit their over-sprouting.
High VEGFA expression is associated with Ectopic Proliferation and Retinal Dysplasia in Zebrafish Optic Pathway Tumors.
Rspo1 (zeige RSPO1 Proteine) is required for hematopoietic stem cell specification through control of parallel signaling pathways controlling HSC (zeige FUT1 Proteine) specification: Wnt16 (zeige WNT16 Proteine)/DeltaC/DeltaD and Vegfa/Tgfbeta1 (zeige TGFB1 Proteine)
Tmem2 regulates hyaluronic acid turnover to promote normal Vegf signaling during developmental angiogenesis.
low levels of Vegf signaling promote overall vascular endothelial differentiation and cell survival by upregulating etv2 expression, while high levels of Vegf signaling promote arterial and inhibit venous specification.
altering the amount of VEGF signaling in endothelial cells by stimulating them with different VEGF concentrations triggered distinct and mutually exclusive dynamic Ca(2 (zeige CA2 Proteine)+) signaling responses that correlated with different cellular behaviors.
Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether downregulate the expression of VEGF and VEGFR, and simultaneously regulates VEGF signaling pathway to prevent angiogenesis.
noncanonical function of tars (zeige TARS Proteine) regulates vascular development presumably by modulating the expression of vegfa
VEGFA produced in the somites is required to initiate adult haemangioblast programming in the adjacent dorsal lateral plate mesoderm.
sequential, isoform-specific VEGFA signaling successively induces the endothelial, arterial, and hematopoietic stem cell programs in the dorsal aorta.
VEGF induces stromal cell migration or recruitment that are required for blood vessel formation.
increased VEGF(170) levels disturb Hand-1 (zeige HAND1 Proteine) expression in the region required for normal heart morphogenesis
data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.
Studied the effect of cyclic uniaxial stretch (20%, 1 Hz), with and without the stimulation of vascular endothelial growth factor (VEGF), on sprouting angiogenesis by employing a stretchable three-dimensional cell culture model.
Study shows that VEGFA mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating VEGF-Ax, an isoform containing a unique 22-amino-acid C terminus extension.
Data indicate that superoxide dismutase (SOD) inhibited high glucose (HG)-induced expression of uPAR and VEGF in bovine retinal microvascular endothelial cell (REC).
Exposure of endothelial cells to VEGF, high glucose, or hydrogen peroxide up-regulated the XBP1 (zeige XBP1 Proteine)/IRE1 alpha (zeige ERN1 Proteine) and ATF6 (zeige ATF6 Proteine) arms of the unfolded protein response compared with untreated cells.
Microvascular endothelial cells are more susceptible than aortic cells to advanced glycation end products-enhanced permeability and that AGE-enhanced permeability is dependent on VEGF expression induced by reactive oxygen species.
VEGF supports germ cell survival and sperm production in bulls.
analysis of polymorphisms of bovine VEGF gene and their associations with growth traits in Chinese cattle
VEGF mRNA expression at estrus was higher than at the early I, early II and late luteal stages (P<0.05), whereas VEGF protein content was greatest at the early I luteal stage and decreased thereafter
Alterations in the expression of VEGF-A and bFGF (zeige FGF2 Proteine) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
VEGF expression has an importance within CTS (zeige TTR Proteine) pathogenesis. Increased ischemia-reperfusion damage, neoangiogenesis, and VEGF expression has an important role frequently CTS (zeige TTR Proteine) occurrence in diabetic patients
In this review, we summarize the properties of VEGF and its receptors that are relevant to bone formation and repair; the roles of VEGF during development of endochondral and membranous bones; and the contributions of VEGF to bone healing during different phases of bone repair. Finally, we discuss contributions of altered VEGF function in inherited disorders with bone defects as part of their phenotypes.
REVIEW. the interplay among the ETS transcription factor (zeige FEV Proteine) ETV2 (zeige ETV2 Proteine), vascular endothelial growth factor, and its receptor VEGFR2/FLK1 (zeige KDR Proteine) is essential for hematopoietic and vascular development. Emerging studies also support the role of these three factors and possible interplay in hematopoietic and vascular regeneration.
VEGF rs699947 and rs3025039 polymorphisms were associated with increased risk of stroke, while rs1570360 and rs699947 were associated with stroke and Extracranial internal carotid artery stenosis.
Claudin-5 (zeige CLDN5 Proteine) was shown to be regulated VEGFR2 (zeige KDR Proteine)/PI3K (zeige PIK3CA Proteine)-Akt (zeige AKT1 Proteine) dependently by VEGF and PI3K (zeige PIK3CA Proteine)-Akt (zeige AKT1 Proteine) independently by histamine. Interleukin-8 (zeige IL8 Proteine) was shown to downregulate claudin-5 (zeige CLDN5 Proteine) by histamine.
TIPE2 suppressed tumor invasiveness and angiogenesis in non-small cell lung cancer via inhibiting the activation of Rac1 and subsequently weakening its downstream effects, including F-actin polymerization and VEGF expression.
High VEGF expression is associated with breast cancer angiogenesis .
Study provide evidence that miR-29c represses VEGFA expression at both mRNA and protein levels by directly targeting to its 3'-UTR.
CD24 induced CRC angiogenesis in Hsp90-dependent manner and activated STAT3-mediated transcription of VEGF.
Cases with high MDSC infiltration, which was inversely correlated with intratumoral CD8(+) T-cell infiltration, exhibited shorter overall survival. In a mouse model, intratumoral MDSCs expressed both VEGFR1 and VEGFR2. VEGF expression in ovarian cancer induced MDSCs, inhibited local immunity, and contributed to poor prognosis
Findings suggest that VEGF gene expression can be suppressed by TNFSF15 (zeige TNFSF15 Proteine)-stimulated activation of the JNK (zeige MAPK8 Proteine)-GATA3 (zeige GATA3 Proteine) signaling pathway which gives rise to up-regulation of miR (zeige MLXIP Proteine)-29b.
The low-molecular-weight heparin (LMWH) Tinzaparin inhibited Von Willebrand factor (VWF (zeige VWF Proteine)) fiber formation and vessel occlusion in tumor vessels by blocking thrombin (zeige F2 Proteine)-induced endothelial cells (ECs) activation and vascular endothelial growth factor-A (VEGF-A)-mediated VWF (zeige VWF Proteine) release.
These data suggest that VEGF expressed by skeletal myofibers may directly or indirectly regulate both hippocampal blood flow and neurogenesis.
Results show that apoE4-driven brain pathology and cognitive impairments in young apoE4 TR mice are associated with down regulation of the VEGF system and can be reversed by upregulation of the expression of VEGF in the hippocampus. These animal model findings suggest that the VEGF system is a promising target for the treatment of apoE4 carriers in Alzheimers disease.
It was shown that peritoneal macrophages are the main suppliers of VEGF at tumor angiogenesis, as evidenced by the data obtained on model system of endothelial cells synchronized in G0/G1 phase.
these results uncover a novel role for VEGF in controlling proper allocation of Isl1 (zeige ISL1 Proteine)(+) cardiac progenitors to their respective descending lineages
endothelial master transcription factor ETS1 promotes global RNAPII pause release, and that this process is governed by VEGF
Results provide evidence that VEGF derived from Osx+ osteoblast progenitor cells is required for optimal ossification of developing mandibular bones and modulates mechanisms controlling BMP-dependent specification and expansion of the jaw mesenchyme.
The MDA-induced VEGF increase was inhibited by autophagy-lysosomal inhibitors. Intravitreal MDA injection in mice increased laser-induced choroidal neovascularization (laser-CNV) volumes. In a mouse model fed a high-linoleic acid diet for 3 months, we found a significant increase in MDA levels, autophagic activity, and laser-CNV volumes
deletion of AT2 receptor reduced SHP-1 activity and restored VEGF actions, leading to an increased blood flow reperfusion after ischemia in diabetes mellitus.
It was concluded that VEGF and factor VIII are important growth factors associated with fetal development in pigs and are identified in all uterine segments.
results are consistent with a participation of (VEFG) in the regulation of the dynamics of oviductal fluid secretion and the oviduct contractibility
Here we demonstrate that VEGF-165 mediates MSC (zeige MSC Proteine) differentiation into ECs via VEGFR-2 (zeige KDR Proteine)-dependent induction of Sox18 (zeige SOX18 Proteine), which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype.
VEGF was significantly downregulated 7 days after cryotherapy of the sclera and stayed at that level until day 14. It returned to baseline by day 21.
VEGF production, blood vessel network and follicle remodeling are impaired by the antiprogesterone RU486.
findings suggest that the augmented neovascular response seen with VEGF administration was through the VEGF-induced upregulation of Notch (zeige NOTCH1 Proteine) signaling.
interleukin-1beta-induced vascular endothelial growth factor in airway smooth muscle cells
Upregulation of VEGF during hypoxia in chondrocyte is mediated partially through HIF-1alpha (zeige HIF1A Proteine).
data shows that members of the VEGF-VEGFR (zeige KDR Proteine) system are temporally and spatially well localized for playing key roles during umbilical cord formation and its intensive growth observed after day 75 of pregnancy
cardiac-specific and hypoxia-induced coexpression of VEGF and Ang1 (zeige ANGPT1 Proteine) improves the perfusion and function of porcine MI heart through the induction of angiogenesis and cardiomyocyte proliferation
Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion
TNF (zeige TNF Proteine) may up-regulate VEGF and stimulate angiogenesis in the mare (zeige C16orf35 Proteine) early corpus luteum.
After acoustic trauma, vascular endothelial growth factor was up-regulated both in the cochlea and vestibule. Expression in both structures suggests a reparative role with potentially therapeutic implications.
Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.
ghrelin (zeige GHRL Proteine) can inhibit intraplaque angiogenesis and promote plaque stability by down-regulating VEGF and VEGFR2 (zeige KDR Proteine) expression, inhibiting the plaque content of macrophages, and reducing MCP-1 (zeige CCL2 Proteine) expression at an advanced stage of atherosclerosis in rabbits
VEGF mRNA abundance was present at low levels at 16 h post-ovulation and remained low at 72 h, but the level increased at 144 h in uterus.
correlation was observed between CT perfusion parameters (BF, BV, PS, and MAV (zeige KLHL2 Proteine)) and expression of VEGF and MVD (zeige MVD Proteine) in tumor tissue
Physiologic ischemic training stimulates VEGF-mediated mobilization of endothelial progenitor cells as well as angiogenesis.
Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.
Therefore, it was reasonable to speculate that the increased expression of VEGF and MMP-9 (zeige MMP9 Proteine) in residual hepatic tumor cells and tumor angiogenesis post-embolization would be responsible for the increased metastatic potentiality and invasiveness.
VEGF expression peaked at 8 weeks after meniscus transplantation
Studied the biocompatibility and neovascularization of the PLGA nanospheres wrapped with vascular endothelial growth factor (VEGF).
VEGF induces TGF-beta1 (zeige TGFB1 Proteine) expression and myofibroblast transformation after glaucoma surgery.
The results of this study are promising concerning the role of VEGF as a diagnostic marker in moderate osteoarthritis
VEGF plays an important role in choroid-retinal endothelial cell proliferation and tube formation.
These findings suggest that FBLN5 (zeige FBLN5 Proteine) may interfere with choroidal neovascularization by downregulating VEGF, CXCR4 (zeige CXCR4 Proteine), and TGFB1 (zeige TGFB1 Proteine) expression and inhibiting choroidl endothelial cell proliferation.
Apelin may play a role in the development of central retinal vein occlusion (CRVO). Apelin has a unique upstream signaling pathway, independent of the VEGF pathway.
Dll4 play an important role in choroidal neovascularization (CNV) angiogenesis, which appears to be regulated by HIF-1alpha and VEGF during the progression of CNV under hypoxic conditions.
A functional network involving VEGF, IGF2, and MMP9 (zeige MMP9 Proteine) in early placental trophoblast cells and maternal endometrium appears to be important for normal placentation.
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.
, vascular endothelial growth factor A
, vascular endothelial growth factor A-A
, vascular endothelial growth factor A-a
, vascular endothelial growth factor 164
, vascular permeability factor
, vascular endothelial growth factor 188
, angiogenic factor
, Vascular permeability factor
, endothelial growth factor-164
, vascular endothelial growth factor VEGF