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Vegfa signaling governs the formation of diverse arteries/veins by distinct cellular mechanisms in vertebrate vasculatures
vascular endothelial growth factor (zeige VEGF Proteine) and Hedgehog (zeige SHH Proteine) pathways have roles in the development of the superficial system of ocular vessel patterning in zebrafish
miR (zeige MYLIP Proteine)-9 modulation of neuronal VEGF-A controls brain angiogenesis in vivo.
Timelapse analysis of individual cardiomyocyte trajectories reveals misdirected cells in zebrafish pdgfra (zeige PDGFRA Proteine) mutants, suggesting that PDGF (zeige PDGFA Proteine) signaling steers cardiomyocytes toward the midline during cardiac fusion. Intriguingly, the ligand pdgfaa is expressed in the endoderm medial to the pdgfra (zeige PDGFRA Proteine)-expressing myocardial precursors.
This study demonstrates the involvement of VEGF signaling in regulating sustained liver injuries after acute alcohol exposure.
we determined that radial glia control this process via the Vegf decoy receptor sFlt1 (zeige FLT1 Proteine): sflt1 (zeige FLT1 Proteine) mutants exhibit the venous over-sprouting observed in radial glia-ablated larvae, and sFlt1 (zeige FLT1 Proteine) overexpression rescues it. Genetic mosaic analyses show that sFlt1 (zeige FLT1 Proteine) function in trunk endothelial cells can limit their over-sprouting.
High VEGFA expression is associated with Ectopic Proliferation and Retinal Dysplasia in Zebrafish Optic Pathway Tumors.
Rspo1 (zeige RSPO1 Proteine) is required for hematopoietic stem cell specification through control of parallel signaling pathways controlling HSC (zeige FUT1 Proteine) specification: Wnt16 (zeige WNT16 Proteine)/DeltaC/DeltaD and Vegfa/Tgfbeta1 (zeige TGFB1 Proteine)
Tmem2 (zeige TMEM2 Proteine) regulates hyaluronic acid turnover to promote normal Vegf signaling during developmental angiogenesis.
low levels of Vegf signaling promote overall vascular endothelial differentiation and cell survival by upregulating etv2 (zeige ETV2 Proteine) expression, while high levels of Vegf signaling promote arterial and inhibit venous specification.
VEGFA produced in the somites is required to initiate adult haemangioblast programming in the adjacent dorsal lateral plate mesoderm.
sequential, isoform-specific VEGFA signaling successively induces the endothelial, arterial, and hematopoietic stem cell programs in the dorsal aorta.
VEGF induces stromal cell migration or recruitment that are required for blood vessel formation.
increased VEGF(170) levels disturb Hand-1 (zeige HAND1 Proteine) expression in the region required for normal heart morphogenesis
data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.
Studied the effect of cyclic uniaxial stretch (20%, 1 Hz), with and without the stimulation of vascular endothelial growth factor (VEGF (zeige VEGF Proteine)), on sprouting angiogenesis by employing a stretchable three-dimensional cell culture model.
Study shows that VEGFA mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating VEGF-Ax, an isoform containing a unique 22-amino-acid C terminus extension.
Data indicate that superoxide dismutase (SOD) inhibited high glucose (HG)-induced expression of uPAR and VEGF in bovine retinal microvascular endothelial cell (REC).
Exposure of endothelial cells to VEGF, high glucose, or hydrogen peroxide up-regulated the XBP1 (zeige XBP1 Proteine)/IRE1 alpha (zeige ERN1 Proteine) and ATF6 (zeige ATF6 Proteine) arms of the unfolded protein response compared with untreated cells.
Microvascular endothelial cells are more susceptible than aortic cells to advanced glycation end products-enhanced permeability and that AGE-enhanced permeability is dependent on VEGF expression induced by reactive oxygen species.
VEGF supports germ cell survival and sperm production in bulls.
analysis of polymorphisms of bovine VEGF gene and their associations with growth traits in Chinese cattle
VEGF mRNA expression at estrus was higher than at the early I, early II and late luteal stages (P<0.05), whereas VEGF protein content was greatest at the early I luteal stage and decreased thereafter
Alterations in the expression of VEGF-A and bFGF (zeige FGF2 Proteine) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
Exosomal transfer of miR (zeige MLXIP Proteine)-100 from mesenchymal stem cells (MSCs) decreases vascular endothelial growth factor (VEGF (zeige VEGF Proteine)) expression through modulating the mTOR (zeige FRAP1 Proteine)/HIF-1alpha (zeige HIF1A Proteine) axis in breast cancer cells.
Circulating tumor cells and serum levels of MMP-2 (zeige MMP2 Proteine), MMP-9 (zeige MMP9 Proteine) and VEGF as markers of the metastatic process in patients with high risk of metastatic progression
Higher VEGF-A expression was related to higher pathological stages in cutaneous melanoma.
Multivariate analyses showed that higher HIF-1alpha (zeige HIF1A Proteine) expression, but not high VEGF, were associated significantly and independently with increased tumor aggressiveness as derived from several well-established aggressiveness criteria.
Data show that serum vascular endothelial growth factor A (VEGF-A) levels before surgery are higher in patients with central nervous system tumors than in non-cancer patients.
VEGFA was overexpressed in endometriosis tissues, and we identified miR (zeige MLXIP Proteine)-34a-5p is able to target the VEGF gene, preventing the latter to function as an inhibitor of angiogenesis. These results imply that miR (zeige MLXIP Proteine)-34a-5p might regulate VEGFA in ESCs (zeige NR2E3 Proteine) and might contribute to the pathogenesis of endometriosis.
Distributions of MCP-1 (zeige CCL2 Proteine) -2518A/G and VEGF -634C/G polymorphisms are significantly different between type 2 diabetes mellitus and diabetic foot ulcer patients
miR203 expression may be upregulated by IL17 (zeige IL17A Proteine) stimulation, and miR203 is a positive regulator of IL17induced VEGF secretion.
VEGF -2578C/A, +936C/T, +405G/C polymorphisms were associated with an elevated susceptibility to renal cell carcinoma (zeige MOK Proteine) (review, meta-analysis).
DDAH-1 (zeige DDAH1 Proteine) expression is associated with promotion of angiogenesis stimulating factor VEGF.
This study showed that the quantity of VEGF in the glioma microenvironment seems to be crucial for the participation of microglia/macrophages on tumor progression.
AK131850 directly competed miR (zeige MLXIP Proteine)-93-5p in N-OC and M-OC through sponge, thereby increasing VEGFa transcription, expression and secretion through derepressing of miR (zeige MLXIP Proteine)-93-5p on VEGFa.
NF-kappaBmiR15abFGF/VEGFA axis contributes to the impaired angiogenic capacity of bone marrowmesenchymal stem cells in high fat dietfed mice.
Results support the idea that excess heparin binding epidermal growth factor-like growth factor (HB-EGF (zeige HBEGF Proteine)) leads to a significant elevation of vascular endothelial growth factor (VEGF (zeige VEGF Proteine)) and ventricular dilatation. These data suggest a potential pathophysiological mechanism that elevated HB-EGF (zeige HBEGF Proteine) can elicit VEGF induction and hydrocephalus.
Over-expression of VEGF-A165b is protective against proteinuria in a mouse model with progressive depletion of all endogenous VEGF-A splice isoforms from the kidney.
The present data suggest that Ischemic preconditioning transiently increases plasma VEGF levels by downregulating miR (zeige MLXIP Proteine)-762 and miR (zeige MLXIP Proteine)-3072-5p in CD34 (zeige CD34 Proteine)-positive BM cells, leading to protection against organ ischemia.
findings are the first to demonstrate the importance of CdGAP in embryonic vascular development and VEGF-induced signaling, and highlight CdGAP as a potential therapeutic target to treat pathological angiogenesis and vascular dysfunction
TGF-beta1 (zeige TGFB1 Proteine)/TbetaRII/Smad3 (zeige SMAD3 Proteine) signaling pathway increased VEGF expression in in oral squamous cell carcinoma tumor-associated macrophages (TAMs). TAMs can promote the tumor angiogenesis by secreting VEGF.
VEGF causes extensive neural stem cell (NSC) remodelling manifested in transition of the enigmatic NSC terminal arbor onto long cytoplasmic processes engaging with and spreading over even remote blood vessels, a configuration reminiscent of early postnatal "juvenile" NSCs.
It was concluded that VEGF and factor VIII are important growth factors associated with fetal development in pigs and are identified in all uterine segments.
results are consistent with a participation of (VEFG) in the regulation of the dynamics of oviductal fluid secretion and the oviduct contractibility
Here we demonstrate that VEGF-165 mediates MSC (zeige MSC Proteine) differentiation into ECs via VEGFR-2 (zeige KDR Proteine)-dependent induction of Sox18 (zeige SOX18 Proteine), which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype.
VEGF was significantly downregulated 7 days after cryotherapy of the sclera and stayed at that level until day 14. It returned to baseline by day 21.
VEGF production, blood vessel network and follicle remodeling are impaired by the antiprogesterone RU486.
findings suggest that the augmented neovascular response seen with VEGF administration was through the VEGF-induced upregulation of Notch (zeige NOTCH1 Proteine) signaling.
interleukin-1beta-induced vascular endothelial growth factor (zeige VEGF Proteine) in airway smooth muscle cells
Upregulation of VEGF during hypoxia in chondrocyte is mediated partially through HIF-1alpha (zeige HIF1A Proteine).
data shows that members of the VEGF-VEGFR (zeige KDR Proteine) system are temporally and spatially well localized for playing key roles during umbilical cord formation and its intensive growth observed after day 75 of pregnancy
cardiac-specific and hypoxia-induced coexpression of VEGF and Ang1 (zeige ANGPT1 Proteine) improves the perfusion and function of porcine MI heart through the induction of angiogenesis and cardiomyocyte proliferation
Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor (zeige VEGF Proteine) Secretion
TNF (zeige TNF Proteine) may up-regulate VEGF and stimulate angiogenesis in the mare (zeige C16orf35 Proteine) early corpus luteum.
After acoustic trauma, vascular endothelial growth factor (zeige VEGF Proteine) was up-regulated both in the cochlea and vestibule. Expression in both structures suggests a reparative role with potentially therapeutic implications.
Studied the role of T help 17 cells (Th17) and STAT3 (zeige STAT3 Proteine)-VEGF pathway in pathogenesis of psoriasis.
ghrelin (zeige GHRL Proteine) can inhibit intraplaque angiogenesis and promote plaque stability by down-regulating VEGF and VEGFR2 (zeige KDR Proteine) expression, inhibiting the plaque content of macrophages, and reducing MCP-1 (zeige CCL2 Proteine) expression at an advanced stage of atherosclerosis in rabbits
VEGF mRNA abundance was present at low levels at 16 h post-ovulation and remained low at 72 h, but the level increased at 144 h in uterus.
correlation was observed between CT perfusion parameters (BF, BV, PS, and MAV (zeige KLHL2 Proteine)) and expression of VEGF and MVD (zeige MVD Proteine) in tumor tissue
Physiologic ischemic training stimulates VEGF-mediated mobilization of endothelial progenitor cells as well as angiogenesis.
Suggest supplemental oxygen inhibits HIF-1alpha (zeige HIF1A Proteine)/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.
Therefore, it was reasonable to speculate that the increased expression of VEGF and MMP-9 (zeige MMP9 Proteine) in residual hepatic tumor cells and tumor angiogenesis post-embolization would be responsible for the increased metastatic potentiality and invasiveness.
VEGF expression peaked at 8 weeks after meniscus transplantation
Studied the biocompatibility and neovascularization of the PLGA nanospheres wrapped with vascular endothelial growth factor (VEGF (zeige VEGF Proteine)).
VEGF induces TGF-beta1 (zeige TGFB1 Proteine) expression and myofibroblast transformation after glaucoma surgery.
The results of this study are promising concerning the role of VEGF as a diagnostic marker in moderate osteoarthritis
Data suggest that microRNA-126 plays role in diabetic retinopathy; here, choroid-retinal endothelial cells exposed to high glucose exhibit down-regulation of microRNA-126 and up-regulation of VEGFA and PIK3R2; overexpression of microRNA-126 down-regulates expression of VEGFA and PIK3R2. (VEGFA = vascular endothelial growth factor A; PIK3R2 = class Ia phosphoinositol-3 kinase regulatory subunit 2 (zeige CCT2 Proteine))
VEGF plays an important role in choroid-retinal endothelial cell proliferation and tube formation.
These findings suggest that FBLN5 (zeige FBLN5 Proteine) may interfere with choroidal neovascularization by downregulating VEGF, CXCR4 (zeige CXCR4 Proteine), and TGFB1 (zeige TGFB1 Proteine) expression and inhibiting choroidl endothelial cell proliferation.
Apelin (zeige APLN Proteine) may play a role in the development of central retinal vein occlusion (CRVO). Apelin (zeige APLN Proteine) has a unique upstream signaling pathway, independent of the VEGF pathway.
Dll4 (zeige DLL4 Proteine) play an important role in choroidal neovascularization (CNV) angiogenesis, which appears to be regulated by HIF-1alpha (zeige HIF1A Proteine) and VEGF during the progression of CNV under hypoxic conditions.
A functional network involving VEGF, IGF2, and MMP9 (zeige MMP9 Proteine) in early placental trophoblast cells and maternal endometrium appears to be important for normal placentation.
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.
, vascular endothelial growth factor A
, vascular endothelial growth factor A-A
, vascular endothelial growth factor A-a
, vascular endothelial growth factor 164
, vascular permeability factor
, vascular endothelial growth factor 188
, angiogenic factor
, Vascular permeability factor
, endothelial growth factor-164
, vascular endothelial growth factor VEGF