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Human MET Protein expressed in Human Cells - ABIN2003241
Bottaro, Rubin, Faletto, Chan, Kmiecik, Vande Woude, Aaronson: Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. in Science (New York, N.Y.) 1991
Show all 7 Pubmed References
In conclusion, these findings indicate that CMs (zeige Cd2ap Proteine) derived from primary culture of NPC (zeige NPC1 Proteine) fractions of BA liver contain a large amount of active HGF (zeige HGF Proteine), which may activate hepatic stem/progenitor cells and promote the appearance of hepatocyte-like cells or their clusters through HGF/c-Met signaling.
despite the marginal occurrence of ALK gene amplification/high polisomy, we did not observed any ALK, MET and ROS (zeige ROS1 Proteine) deregulation in sarcomatoid carcinoma of head and neck
These results hold promise that dual targeting of HGF (zeige HGF Proteine) and MET by combining extracellular ligand inhibitors with intracellular MET TKIs could be an effective intervention strategy for cancer patients who have acquired resistance that is dependent on total MET protein.
The acquired sensitivity to erlotinib supports the known crosstalk between MET and the HER family of receptors. For the first time, we show inactivation of NF2 (zeige NF2 Proteine) during acquisition of resistance to MET-TKI that may explain the refractoriness to erlotinib in these cells.
c-MET phosphorylation is regulated by autophagy via an mTORC2 (zeige CRTC2 Proteine)-dependent mechanism.
Fusion of TPR(2 (zeige DNAJC7 Proteine)-142) protein to the MET intracellular domain strongly and selectively stabilizes the alphaG helix of the MET kinase domain.
cabozantinib suppressed MMP1 (zeige MMP1 Proteine) expression by blocking HGF (zeige HGF Proteine)-MET signaling and that HGF (zeige HGF Proteine)-MET-MMP1 (zeige MMP1 Proteine) signaling is involved in the invasiveness and proliferation of BCa (zeige BLNK Proteine) cells. These results suggest that cabozantinib might prove useful for future treatment of muscle-invasive BCa (zeige BLNK Proteine).
Our data reveal that clear-cell RCC (zeige XRCC1 Proteine) with MET upregulation show an aggressive behavior and MET copy number increase is evident in a substantial percentage of patients with high-grade carcinomas and metastatic disease.
These findings indicate that RON and c-Met facilitate metastasis through ERK1/2 signaling and that targeting RON and c-Met with foretinib may be an attractive therapeutic option for suppressing Prostate cancer metastasis
IGF1R (zeige IGF1R Proteine) signaling under the given experimental conditions and NSCLC genetic background dictates the functional endpoint mechanism for TKI resistance. Manipulating this regulatory role of IGF1R (zeige IGF1R Proteine) can force the functional endpoint mechanism for TKI resistance in a defined and targetable direction here illustrated by the observed MET-amplification.
Met has a role in promoting formation of double minute chromosomes induced by Sei-1 (zeige SERTAD1 Proteine) in NIH-3T3 murine fibroblasts
Genetic activation of the antioxidant transcription factor Nrf2 improves liver damage and repair in hepatocyte-specific c-met-deficient mice mainly through restoring a balance in the cellular redox homeostasis.
MET promoted the development of squamous tumors by stimulating the synthesis and release of ligands that activate the epidermal growth factor receptor (EGFR (zeige EGFR Proteine)).
through the activation of EGFR, MET activation parallels a RAS pathway to contribute to human and mouse cutaneous cancers.
Results show that c-MET expression is significantly low in pancreatic neuroendocrine tumors (PNETs) and is under the regulation of Meg3-mediated transcriptional and epigenetic mechanisms which contributes to the pathogenesis of PNETs.
Findings indicate a role for the hepatocyte growth factor receptor HGFR/c-MET pathway in neutrophil recruitment and function and suggest that c-MET inhibitor co-treatment may improve responses to cancer immunotherapy in settings beyond c-MET-dependent tumors.
Results demonstrate a new mechanism for the modulation of synapse formation, whereby MET activation induces an alignment of presynaptic and postsynaptic elements that are necessary for assembly and formation of functional synapses by subsets of neocortical neurons that express MET/beta-catenin (zeige CTNNB1 Proteine) complex.
MET signaling regulates intestinal homeostasis and regeneration, as well as adenoma formation. These activities of MET are promoted by the stem cell CD44 (zeige CD44 Proteine) isoform CD44v4-10.
a c-Met/ETS-1 (zeige ETS1 Proteine)/matrix metalloproteinase-14 (MMP-14 (zeige MMP14 Proteine)) axis that controls VE-cadherin (zeige CDH5 Proteine) degradation, endothelial mesenchymal transition, and vascular abnormality.
We found the roles of hepatocyte growth factor (HGF (zeige HGF Proteine)) signaling in stria vascularis development for the first time and that lack of HGF (zeige HGF Proteine) signaling in the inner ear leads to profound hearing loss in the mouse. Our findings reveal a novel mechanism that may underlie human deafness DFNB39 (zeige HGF Proteine) and DFNB97. Our findings reveal an additional example of context-dependent c-MET signaling diversity, required here for proper cellular inva
possible cooperative role of the EGF (zeige EGF Proteine) and HGF (zeige HGF Proteine) pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.
, HGF/SF receptor
, SF receptor
, hepatocyte growth factor receptor
, met proto-oncogene tyrosine kinase
, proto-oncogene c-Met
, scatter factor receptor
, tyrosine-protein kinase Met
, HGF receptor c-Met