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These results suggest that there is an EGF (zeige EGF Proteine) signaling network in the zebrafish ovarian follicle, and the functionality of this network is self-regulated by its own members.
These results suggest that HBEGF is an important EGFR (zeige EGFR Proteine) ligand in cervical cancer and that cervical cancer cells are the predominant source of HBEGF. Therefore, we propose an autocrine EGFR (zeige EGFR Proteine) stimulation model in cervical carcinomas.
macrophage-secreted MMP-9 (zeige MMP9 Proteine) released HB-EGF from macrophages, which increased MMP9 (zeige MMP9 Proteine) in OVCA433, resulting in a positive feedback loop to drive HB-EGF release and increase proliferation in co-culture.
Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P < 5 x 10(-8)) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1.
HB-EGF is implicated in DNA double strand breaks repair as silencing of HB-EGF increased gammaH2AX (zeige H2AFX Proteine) foci half-life as well as USP9X (zeige USP9X Proteine) expression, two features that could be linked to the observed effect on Mcl-1 (zeige MCL1 Proteine).
Heparan sulfate proteoglycans and heparin derivatives further enhance HBEGF-induced differentiation by forming a complex with the epidermal growth factor receptor (zeige EGFR Proteine)
this study suggests that HBEGF promotes the formation of gliomas, is necessary for tumor maintenance and therefore may be a novel therapeutic target.
Results show that HBEGF is highly expressed in primary ovarian tumors and increases as the disease progresses.
Serous carcinomatous component championed by expression of HB-EGF predisposes to recurrence/metastasis in stage I metastasis and recurrence in stage I uterine malignant mixed mullerian tumor.
Annexin A2 (zeige ANXA2 Proteine) and HB-EGF are overexpressed and are being secreted into serum in Her-2 (zeige ERBB2 Proteine) negative breast cancer patients.
Study demonstrates that HBEGF is post-transcriptionally regulated by low O2 (placental environment) through a mechanism involving interactions of miRNAs with its 3'UTR.
via binding to hypoxia-responsive elements in MMP9 (zeige MMP9 Proteine) gene, HIF1alpha (zeige HIF1A Proteine) stimulated MMP9 (zeige MMP9 Proteine) expression, and therefore appeared as a prominent intermediary in HB-EGF-induced blood-brain barrier damage
Using the best available methods for preclinical evaluation in animal models, it is likely that HB-EGF-like growth factor treatment leads to regeneration of chronic tympanic membrane perforations and restoration of the tympanic membrane to normal function, suggesting a potential route for nonsurgical treatment.
In a clinically relevant CADASIL (zeige NOTCH3 Proteine) mouse model, we show that exogenous ADAM17 (zeige ADAM17 Proteine) or HB-EGF restores cerebral arterial tone and blood flow responses, and identify upregulated voltage-dependent potassium channel (zeige KCNAB2 Proteine) (KV) number in cerebral arterial myocytes as a heretofore-unrecognized downstream effector of TIMP3 (zeige TIMP3 Proteine)-induced deficits.
HB-EGF stimulates Prss56 expression via EGFR (zeige EGFR Proteine)-ERK (zeige EPHB2 Proteine) pathway.
HB-EGF Tg mice were shown to develop more severe liver fibrosis when treated with carbon tetrachloride or bile duct ligation, with increased matrix metalloproteinases 13 activity and enhanced expression of fibrogenic genes including alpha-smooth muscle actin (zeige ACTG2 Proteine) and collagen I.
These results indicate that ATX (zeige ENPP2 Proteine)-lysophosphatidic acid-LPA3 (zeige LPAR3 Proteine) signaling at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF and COX-2 pathways.
our results suggest that shedding of HB-EGF from endothelium plays an important role in Ang II (zeige AGT Proteine)-induced renal injury by linking Ang II (zeige AGT Proteine)-AT1R (zeige AGTRAP Proteine) with EGFR (zeige EGFR Proteine) transactivation.
Results suggest that HB-EGF secreted from KRas-mutated colorectal cancer cells promotes intestinal myofibroblasts migration through ERK (zeige EPHB2 Proteine) and JNK (zeige MAPK8 Proteine) activation, which, in turn, could support cancer progression.
this study revealed that HB-EGF as well as HGF (zeige HGF Proteine) inhibited BDL-induced cholestatic liver injury by predominantly exerting acute cytoprotective and chronic antifibrotic effects, respectively.
Abnormal keratinocyte migration and down-regulated expression of the Hbegf gene might be associated with impaired eyelid development in B6-Co mice.
These results indicate that HB-EGF and its receptors expression changed in bovine endometrium throughout the oestrous cycle; IFN-tau increased their expression in cultured endometrial cells.
Heparin-binding EGF-like growth factor is main component in chromaffin granules responsible for neurotrophic effect on dopaminergic neurones. Protective effects on nigrostriatal dopaminergic neurones. Candidate for treatment of Parkinson's disease.
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
proheparin-binding EGF-like growth factor
, heparin-binding EGF-like growth factor
, Heparin-binding EGF-like growth factor
, diphtheria toxin receptor (heparin-binding EGF-like growth factor)
, diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor)
, heparin-binding epidermal growth factor
, Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor)
, heparin binding epidermal growth factor-like growth factor
, heparin-binding epidermal -growth - like growth factor
, heparin-binding epidermal -growth factor
, diphtheria toxin receptor
, heparin-binding epidermal growth factor-like growth factor