HBEGF Protein (Fc Tag)

Produktnummer ABIN7092863

Produktdetails

Target: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses HBEGF Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant mouse HBEGF (24-160) protein with C-terminal human Fc tag

Spezifität: Mouse HBEGF (24-160) (Gln24-Thr160) hFc (Glu99-Ala330)

Produktmerkmale: Extracellular Domain Protein

Aufreinigung: affinity purification

Reinheit: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with deionized water

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Andere Bezeichnung: HBEGF (HBEGF Produkte)

Synonyme: hbegf Protein, zgc:165443 Protein, HBEGF Protein, zgc:175091 Protein, DTR Protein, DTS Protein, DTSF Protein, HEGFL Protein, Dtr Protein, GFHB Protein, Hb-egf Protein, Hegfl Protein, AW047313 Protein, Dts Protein, HB-EGF Protein, heparin-binding EGF-like growth factor b Protein, heparin binding EGF like growth factor Protein, Heparin-binding EGF-like growth factor Protein, heparin-binding EGF-like growth factor a Protein, heparin-binding EGF-like growth factor Protein, hbegfb Protein, HBEGF Protein, hbegf Protein, hbegfa Protein, Hbegf Protein

Hintergrund: Synonymes: AW047313, Dtr, Dts, Hegfl
Description: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.[UniProtKB/Swiss-Prot Function]

Molekulargewicht: predicted molecular mass of 41.3 kDa after removal of the signal peptide.The apparent molecular mass of mHBEGF(24-160)-hFc is 40-55 kDa due to glycosylation.

UniProt: Q06186

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung