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Gene-based analysis identified EPHA6 (zeige Epha6 Proteine) as the gene most significantly associated with paclitaxel-induced neuropathy...This first study sequencing EPHA genes revealed that low-frequency variants in EPHA6 (zeige Epha6 Proteine), EPHA5 (zeige EPHA5 Proteine), and EPHA8 contribute to the susceptibility to paclitaxel-induced neuropathy
High EPHA8 expression is associated with epithelial ovarian cancer.
Human miR (zeige MLXIP Proteine)-10a and EphA8 regulate epithelial-mesenchymal transition (EMT (zeige ITK Proteine)) to affect glioma cell migration and invasion.
RINL, as a GEF (zeige SLC2A4RG Proteine) for Rab5 (zeige RAB5A Proteine) subfamily, is implicated in the EphA8-degradation pathway via its interaction with odin (zeige ANKS1A Proteine).
role in stimulated cell migration in presnce of p110 gamma (zeige PIK3CG Proteine) PI-3 (zeige PI3 Proteine) kinase
EphA8 receptor is capable of inducing a sustained increase in MAPK (zeige MAPK1 Proteine) activity, thereby promoting neurite outgrowth in neuronal cells
Data suggest that Odin (zeige ANKS1A Proteine) levels play a critical role in regulating the stability of EphA2 (zeige EPHA2 Proteine) and A8 in response to ligand stimulation and by modulating the ubiquitination process.
Regulation of EphA8 gene expression is accomplished by TALE homeobox (zeige PRRX1 Proteine) transcription factors during development of the mesencephalon.
These findings support a possible function for Anks family proteins as scaffolding proteins of the EphA8 signaling pathway.
This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.
EPH receptor A8
, protein-tyrosine kinase (E17)
, ephrin receptor EphA8-like
, ephrin type-A receptor 8-like
, EPH- and ELK-related kinase
, EPH- and ELK-related tyrosine kinase
, EPH-like kinase 3
, ephrin type-A receptor 8
, hydroxyaryl-protein kinase
, protein-tyrosine kinase
, tyrosine-protein kinase receptor EEK
, tyrosylprotein kinase
, Ephrin type-A receptor 8 precursor (Tyrosine-protein kinase receptor EEK) (EPH-and ELK-related kinase)