EPH Receptor A8 Protein (EPHA8) (His tag)

Produktnummer ABIN7319871

Produktdetails

Target: EPH Receptor A8 (EPHA8)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses EPH Receptor A8 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human EphA8 (C-6His)

Sequenz: Glu31--Thr542

Produktmerkmale: Recombinant Human Ephrin type-A receptor 8 is produced by our Mammalian expression system and the target gene encoding Glu31-Thr542 is expressed with a 6His tag at the C-terminus.

Reinheit: >95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: EPH Receptor A8 (EPHA8)

Andere Bezeichnung: EphA8 (EPHA8 Produkte)

Synonyme: TK Protein, tke17-a Protein, si:ch211-122l14.1 Protein, EPHA8 Protein, EEK Protein, EK3 Protein, HEK3 Protein, AW047546 Protein, Eek Protein, Hek3 Protein, mKIAA1459 Protein, EPH receptor A8 L homeolog Protein, EPH receptor A8 Protein, eph receptor A8 Protein, Eph receptor A8 Protein, epha8.L Protein, EPHA8 Protein, epha8 Protein, Epha8 Protein

Hintergrund:

Background: EphA8, also known as Hek3 and Eek, is a 120 kDa glycosylated member of the Eph family of transmembrane receptor tyrosine kinases. The A and B classes of Eph proteins are distinguished by Ephrin ligand binding preference but have a common structural organization. Eph-Ephrin interactions are widely involved in the regulation of cell migration, tissue morphogenesis, and cancer progression. Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth.

Synonym: EEK, EK3, HEK3, EPH- and ELK-related kinase, EPH- and ELK-related tyrosine kinase, EPH receptor A8, EphA8, EPH-like kinase 3, ephrin type-A receptor 8, Hek3

Molekulargewicht: 57.4 kDa

UniProt: P29322

Pathways: RTK Signalweg