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EPHA7 is a positive upstream factor of C/EBPbeta contributing to the transcription and translation of KLF4, promoting ovulation via ADAMTS1. We demonstrated the functional role of EPHA7 in PCOS, which explains how the loss of EPHA7 underlies the ovulatory dysfunction.
receptor phosphorylation of EphA7, at least in part, suppress prostate cancer tumor malignancy through targeting PI3K/Akt signaling pathways.
these findings suggest that miR-448 functioned as a tumor suppressor gene in the development of osteosarcoma through targeting EPHA7.
the interactions of EphA5/ephrinA5 and/or EphA7/ephrinA5 between HSPCs and BMSCs, independently and cooperatively, play a role in HSPC colony formation through the upregulation of GM-CSFR. Furthermore, the adhesion/migration of HSPCs appears to be mediated in part through the activation of Rac1.
We have demonstrated the physical association and cellular co-localization of EPHA7 and EPHA10 in breast carcinoma cells. The nuclear co-localization of these two receptors in invasive MDA-MB-231 cells suggests their involvement in transcriptional activation of genes involved in invasiveness.
Eph receptor A7 may have an important role in the pathogenesis of nonsmall cell lung cancer by regulating PTEN expression via thephosphatase and tensin homolog/AKT pathway.
Depletion of EphA7 remarkably inhibited the proliferation and invasion of Hep-2 and AMC-HN-8 cells in comparison to control and EphA7 siRNA negative control (NC)-transfected cells.
Authors observed that the extracellular region of the EphA7 receptor was critical for interacting with caspase-8, whereas the cytoplasmic region of EphA7 was not.
miR-137 is able to directly bind to the EPHA7 3'UTR and negatively regulate the expression of EPHA7 in HUVECs.
MTDH and EphA7 are markers for metastasis and poor prognosis of gallbladder adenocarcinoma.
The expression of EphA7 and/or MTDH might be closely related to the carcinogenesis, progression, clinical biological behaviors and prognosis of gallbladder adenocarcinoma.
Overexpression of EphA7 and/or MTDH might indicate poor prognosis in squamous cell cancer of the tongue.
Data found significant correlations between ephA2, ephA4, ephA7, ephB4, and ephB6 and overall and/or recurrence-free survival in large microarray datasets.
EPHA7 acts as a tumor suppressor in vivo and is targeted by genomic deletions and differential epigenetic silencing in human lymphomas.
EphA7 protein expression is significantly correlated with the biological behavior of primary hepatocellular carcinoma.
Data shew that the identification of three novel candidates as EPH receptor genes might indicate a link between perturbed compartmentalization of early neoplastic lesions and breast cancer risk and progression.
analysis of the secreted form of EphA7 in lung cancer
Eph-A5 and Eph-A7 staining intensity was identified as independent prognostic factors for pancreatic ductal adenocarcinoma
downregulation of an Eph family gene in a solid tumor via aberrant 5'CpG island methylation, providing evidence that EphA7 gene is involved in human colorectal carcinogenesis
EphA7 expression in 52 gastric carcinoma was consistent with its transcript expression, with the protein being significantly overexpressed in younger patients (P = .016) and in patients with advanced tumors (P = .033)
Data suggest BMI1 overexpression as a novel mechanism leading to EphA7 inactivation via H3K27 trimethylation and DNA methylation by which BMI-1 controls cell proliferation in the postnatal lateral ventricle wall.
The present study demonstrates that EphA7 receptors, despite their similar structure, have distinct in vivo effects on corticothalamic system projections into the ventrobasal complex /medial division of the posterior nuclear group.
Results suggest that EphA7 plays an important role in the developmental formation of cochlear innervation pattern through controlling spiral ganglion neuron fiber ontogeny
Truncated EPHA7 promotes cell reprogramming by inducing ERK activity reduction.
Data show the effects of genetic loss of ephrin-A5, Eph receptors EphA4, and EphA7 on the development of medulloblastoma tumors in the smoothened (Smo) transgenic mouse model.
Results support the hypothesis that the anatomical organization of striatal and thalamic neurons expressing EphA7 receptors restricts the topographic distribution of cortical afferents from medial regions of S1 which express high levels of ephrin-A5
EphA4/EphA7 from the pericloacal mesenchyme signal via ephrin B2 to mediate nephric duct insertion.
The role of cell-based signaling via the receptor tyrosine kinase EphA7 in guiding the extension and maturation of cortical dendrites, was examined.
multi-protein complex comprising ephrinA5, EphA7, and TNFR1 may constitute a platform for inducing caspase-dependent apoptotic
Data show that Dlx5 and Msx2 play a critical role in controlling cranial neural tube morphogenesis by regulating cell adhesion via the ephrinA5 and EphA7 pathway.
This study demonstrated a potential role for EphA/ephrin-A signaling in the initial guidance of corticofugal axons.
We used in utero electroporation-mediated EphA7 overexpression in developing somatosensory CT axons to dissect EphA7/ephrin-A-dependent mechanisms involved in regulating both initial targeting and postnatal growth of the corticothalamic projections.
Our study identifies a novel repertoire of cortical neuron genes that may act upstream of, or together with EphA7, to control the patterning of cortical areas.
Study identified EPHA7 as a tumor suppressor that is shed from germinal center B cells and lost in follicular lymphoma.
The dorsal midline-specific EphA7 enhancer resides on the 457D20 EphA7 BAC clone and is localized to a 35 kb genomic region in between +345.7 kb to +379.8 kb downstream of the EphA7 transcription start site.
Neocortical expression of Epha7 during development remains stable in the absence of cellular contacts and thalamocortical connections.
ephrin-A/EphA receptor signalling plays a key role in controlling the size of the mouse cerebral cortex by regulating cortical progenitor cell apoptosis
EphA7-mediated signaling on neocortical axons controls the within-nucleus topography of corticothalamic projections in the thalamus. (EphA7)
EphA7 is a direct downstream target of Hoxd13 and Hoxa13 during limb development
HOXA13 directly regulates EphA6 and EphA7 in the developing genital tubercle.
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
ephrin type-A receptor 7
, EPH receptor A7
, ephrin receptor EphA7
, ephrin type-A receptor 7-like
, EPH homology kinase 3
, EPH-like kinase 11
, Eph homology kinase-3
, receptor protein-tyrosine kinase HEK11
, tyrosine-protein kinase receptor EHK-3
, developmental kinase 1
, embryonic brain kinase
, Eph-like receptor tyrosine kinase
, tyrosine-protein kinase receptor CEPHA7