EPH Receptor A7 Protein (EPHA7) (GST tag,His tag)
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- Target Alle EPH Receptor A7 (EPHA7) Proteine anzeigen
- EPH Receptor A7 (EPHA7)
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
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Spezies
- Human
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Quelle
- Baculovirus infected Insect Cells
- Aufreinigungstag / Konjugat
- Dieses EPH Receptor A7 Protein ist gelabelt mit GST tag,His tag.
- Verwendungszweck
- Recombinant Human EphA7/EHK3 Protein (His & GST Tag)(Active)
- Sequenz
- Gly579-Val998
- Produktmerkmale
- A DNA sequence encoding the human EPHA7 (NP_004431) (Gly579-Val998) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- Reinheit
- > 94 % as determined by reducing SDS-PAGE.
- Endotoxin-Niveau
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- The specific activity was determined to be 9.5 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.
- Top Product
- Discover our top product EPHA7 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Frozen, Liquid
- Buffer
- Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 8.0, 10 % glycerol
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- EPH Receptor A7 (EPHA7)
- Andere Bezeichnung
- EphA7/EHK3 (EPHA7 Produkte)
- Synonyme
- fc51g03 Protein, wu:fc51g03 Protein, si:dkey-23k6.1 Protein, EHK3 Protein, HEK11 Protein, Cek11 Protein, Ebk Protein, Ehk3 Protein, Hek11 Protein, Mdk1 Protein, CEPHA7 Protein, EPH receptor A7 Protein, eph receptor A7 Protein, ephrin type-B receptor 1-B Protein, Eph receptor A7 Protein, EPHA7 Protein, epha7 Protein, LOC100166161 Protein, Epha7 Protein
- Hintergrund
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Background: Ephrin type-A receptor 7, also known as EphA7, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Eph receptor-mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. Down-regulation of EphA7 secondary to hypermethylation has been reported in colorectal cancer. The expression of EphA7 was reduced in all tested gastric cancer cell lines, however, there is marked variability in expression among gastric carcinoma specimens. EphA7 may have roles in the pathogenesis and development of gastric carcinomas.
Synonym: Ephrin Type-A Receptor 7, EPH Homology Kinase 3, EHK-3, EPH-Like Kinase 11, EK11, hEK11, EPHA7, EHK3, HEK11
- Molekulargewicht
- 75.2 kDa
- NCBI Accession
- NP_004431
- Pathways
- RTK Signalweg
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