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These results demonstrate a novel role for SORLA (zeige SORL1 Proteine) as a physiological and pathological EphA4 modulator.
The expression of both EphA4-FL and EphA4-N was significantly higher in the nervous tissue of SOD1 (zeige SOD1 Proteine)(G93A) compared to wild-type mice suggesting that both forms are modulated during the disease process.
the PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine), Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling pathways as well as ERK1/2 downstream of EPHA4 receptor activation, play an important role in the regulation of events related with the EMT (zeige ITK Proteine) development, which may be associated with the therapeutic failure in rectal cancer after radiotherapy.
Molecular interactions of EphA4, growth hormone receptor (zeige GHR Proteine), Jak2 (zeige JAK2 Proteine), and STAT5B (zeige STAT5B Proteine) have been described.
Findings demonstrated that mutant alpha2-chimaerin and EphA4 have different genetic interactions in distinct motor neuron pools: abducens neurons use bidirectional ephrin signaling via mutant alpha2-chimaerin to direct growth, while cervical spinal neurons use only ephrin forward signaling
Reduced EphA4 expression is associated with EBV-associated B lymphoma.
No difference was found in the expression of EPHA4 in morphologically normal glands, HGPIN, or prostatic cancer.
we supposed that EphA4 interacted with CDK5 (zeige CDK5 Proteine) and promoted its expression which in turn enhanced p-AKT (zeige AKT1 Proteine) expression and promoted cell adhesion-mediated drug resistance in multiple myeloma.
EphA4 was reduced in breast carcinoma, which is associated with high grade, advanced TNM (zeige ODZ1 Proteine) stage, lymph node metastasis, and poor outcome of patients
Host EphA4 expression regulates cancer development mainly via EphA4-mediated IGF1 (zeige IGF1 Proteine) synthesis signal.
ephrin-B2 (zeige EFNB2 Proteine) and EphA4 have graded and modular expression patterns in the developing inferior colliculus
findings suggest a role for EphA4 in shaping cortical oscillations during sleep that is independent from sleep need
The present study demonstrates that EphA4 and EphA7 (zeige EPHA7 Proteine) receptors, despite their similar structure, have distinct in vivo effects on corticothalamic system projections into the ventrobasal complex /medial division of the posterior nuclear group.
These results suggest that EphA4, a novel and promising target for treatment, exacerbates EBI (zeige TBL1X Proteine) through an Ephexin-1 (zeige NGEF Proteine)/ROCK2 (zeige ROCK2 Proteine) pathway after subarachnoid hemorrhage.
Our studies show that forward signaling through the EphA4 tyrosine kinase receptor (zeige KDR Proteine), mediated by ephrins expressed by subpopulations of neuroblasts and astrocytes, is required for compact, directional organization of neuroblasts and astrocytes within the pathway and efficient transit of neuroblasts through the anterior forebrain to the olfactory bulb.
Findings suggest a putative novel mechanism for desipramine to modulate long-term potentiation through the regulation of the ephrinA3/EphA4 signaling pathway
Delineation of the specific mutation in EphA4 in this strain is important for further functional studies, such as protein-protein interactions, immunostaining and gene compensatory studies, investigating the mechanism underlying the effects of altered function of Eph (zeige EPHA1 Proteine) family of receptor tyrosine kinases on phenotype.
expression of Eph (zeige EPHA1 Proteine) A1, A2, A4, and A7 was strongly detected in endometrial epithelial cells during early pregnancy.
The EphA4 gene is significantly associated with litter size in pigs.
EphA4-dependent Brachyury (zeige TBX1 Proteine) expression is required for dorsal mesoderm involution in the Xenopus gastrula.
show that EphA4 and its putative ligand, ephrin-A1 (zeige EFNA1 Proteine) are expressed in a complementary manner in the involuting mesodermal and non-involuting ectodermal layers of early gastrulae, respectively
Downregulation of EphA4a compromises actomyosin cables and cells with different rhombomeric identity intermingle, and the phenotype is rescued enhancing myosin II activity.
EphA4 (zeige EPHA3 Proteine) is required for cell adhesion and rhombomere-boundary formation in the zebrafish.
Data show that EfnB2a (zeige EFNB2 Proteine) is required in developing hindbrain for normal cell affinity and that EphA4 (zeige EPHA3 Proteine) and EfnB2a (zeige EFNB2 Proteine) regulate cell affinity independently within their respective rhombomeres.
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
, EPH-like kinase 8
, TYRO1 protein tyrosine kinase
, ephrin type-A receptor 4
, receptor protein-tyrosine kinase HEK8
, tyrosine-protein kinase TYRO1
, tyrosine-protein kinase receptor SEK
, ephrin receptor epsilon
, EPH receptor A4
, ephrin receptor EphA4
, ephrin receptor EphA4-like
, ephrin type-A receptor 4-like
, tyrosine-protein kinase receptor MPK-3
, tyrosine-protein kinase receptor SEK-1
, ephrin type-A receptor 4-B
, receptor tyrosine kinase
, tyrosine-protein kinase receptor PAG
, eph receptor A3
, eph-like kinase 2
, eph-like receptor tyrosine kinase 1
, ephrin type-A receptor 4a
, tyrosine-protein kinase receptor ZEK2