EPH Receptor A4 Protein (EPHA4) (AA 20-547) (His tag)

Produktnummer ABIN7274561

Produktdetails

Target: EPH Receptor A4 (EPHA4)

Protein-Typ: Recombinant

Proteineigenschaft: AA 20-547

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses EPH Receptor A4 Protein ist gelabelt mit His tag.

Verwendungszweck: Mouse EPHA4 Protein

Sequenz: Val20-Thr547

Produktmerkmale: Recombinant Mouse EPHA4 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val20-Thr547.

Reinheit: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: EPH Receptor A4 (EPHA4)

Andere Bezeichnung: EPHA4 (EPHA4 Produkte)

Synonyme: HEK8 Protein, SEK Protein, TYRO1 Protein, RGD1560587 Protein, ephe Protein, EPHA4 Protein, Ci-Eph1 Protein, sek Protein, hek8 Protein, rtk1 Protein, tyr01 Protein, 2900005C20Rik Protein, AI385584 Protein, Cek8 Protein, Hek8 Protein, Sek Protein, Sek1 Protein, Tyro1 Protein, rb Protein, XEpha4 Protein, sek-1 Protein, epha4 Protein, pag Protein, EphA4 Protein, apha3 Protein, ek2 Protein, epha3 Protein, sb:cb246 Protein, zek2 Protein, zgc:109882 Protein, EPH receptor A4 Protein, Eph receptor A4 Protein, ephrin receptor epsilon Protein, EPH receptor A4 S homeolog Protein, EPH receptor A4 L homeolog Protein, eph receptor A4a Protein, EPHA4 Protein, Epha4 Protein, ephe Protein, epha4 Protein, epha4.S Protein, epha4.L Protein, epha4a Protein

Hintergrund: The expression and activation of EphA4 in the various cell types in a knee joint was upregulated upon an intraarticular injury. To determine if EphA4 signaling plays a role in osteoarthritis, we determined whether deficient EphA4 expression (in EphA4 knockout mice) or upregulation of the EphA4 signaling (with the EfnA4-fc treatment) would alter cellular functions of synoviocytes and articular chondrocytes. In synoviocytes, deficient EphA4 expression enhanced, whereas activation of the EphA4 signaling reduced, expression and secretion of key inflammatory cytokines and matrix metalloproteases.

Molekulargewicht: 59.4 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.

Pathways: RTK Signalweg