EFNA4 Proteine (EFNA4)

Bezeichnung:: Ephrin A4 Proteine (EFNA4)

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Synonyme:: EFL-4, EFL4, EFNA4, Epl4, EPLG4, LERK-4, LERK4

alle Proteine anzeigen	Gen	GeneID	UniProt
Maus EFNA4	EFNA4	13639	O08542
Ratte EFNA4	EFNA4	310643
Human EFNA4	EFNA4	1945	P52798
Weitere Synonyme anzeigen

Verknüpfte Pathways mit EFNA4 Proteine

RTK Signalweg

Weitere Produktkategorien zu EFNA4 Protein

Weitere Proteine zu EFNA4 Interaktionspartnern

Mouse (Murine) Ephrin A4 (EFNA4) Interaktionspartner

In a model of temporal lobe epilepsy, Ephrin-A4 and Ephrin-A5 (zeige EFNA5 Proteine) increase in the hippocampus in a spatiotemporal course.
ephrin-A4 plays an important role in retinal NV and is a potential target against retinal NV. The proangiogenic function of ephrin-A4 may be linked to its crucial role in the VEGF (zeige VEGFA Proteine) signaling pathway.
Downregulation of the EphA4 (zeige EPHA4 Proteine) receptor via siRNA transfection reduced the repulsive effect of ephrin-A3 (zeige EFNA3 Proteine), indicating that EphA4 (zeige EPHA4 Proteine) mediates at least in part the repulsive effect of ephrin-A3 (zeige EFNA3 Proteine).
LIM homeodomain proteins control axon pathways topographic projections in the limb through control of EphA receptors and ephrin-A ligands in motor neurons and limb mesenchymal cells.
Ephrin A4 receptor in the thalamus and ephrin A4 in the cerebral cortex control intra-areal topographic mapping of thalamocortical axons.

Human Ephrin A4 (EFNA4) Interaktionspartner

Study present for the first time in vitro and in vivo evidence suggesting that the major role of two ephrin A4 isoforms in chronic lymphocytic leukemia could be related with a non-previously described mechanism of survival linked to extravasation strongly dependent on integrin signaling.
The present study provides evidence that microglia upregulates endothelial ephrin-A3 (zeige EFNA3 Proteine) and ephrin-A4 to facilitate in vitro angiogenesis of brain endothelial cells, which is mediated by microglia-released TNF-alpha (zeige TNF Proteine).
The interaction between ephrin-As, Eph (zeige EPHA1 Proteine) receptors and integrin alpha3 is plausibly important for the crosstalk between Eph (zeige EPHA1 Proteine) and integrin signalling pathways at the membrane protrusions and in the migration of brain cancer cells.
The cytoplasmic pattern of ephrin A4 could identify a subgroup of primary osteosarcoma patients with a high liability for progression, poor prognosis, and inferior response to chemotherapy.
This provides genetic evidence that Twist1 (zeige TWIST1 Proteine), Msx2 and Efna4 function together in boundary formation and the pathogenesis of coronal synostosis.
CLL B-cells showed a more heterogeneous Eph (zeige EPHA1 Proteine)/EFN profile, specially EFNA4, EphB6 (zeige EPHB6 Proteine) and EphA10 (zeige EPHA10 Proteine). EphB6 (zeige EPHB6 Proteine) and EFNA4 were further related with the clinical course of CLL.
EFNA4-EphA2 (zeige EPHA2 Proteine) interactions are involved in Chronic lymphocytic leukemia cell trafficking between blood and the tissues

EFNA4 Protein Überblick

Protein Überblick

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified.

Alternative names and synonyms associated with EFNA4

ephrin A4 (EFNA4)
ephrin-A4 L homeolog (efna4.L)
ephrin-A4 (efna4)
ephrin A4 (Efna4)

EFL-4 Protein
EFL4 Protein
EFNA4 Protein
Epl4 Protein
EPLG4 Protein
LERK-4 Protein
LERK4 Protein

Bezeichner auf Proteinebene für Ephrin A4 Proteine (EFNA4)

ephrin A4 , ephrin-A4 , EPH-related receptor tyrosine kinase ligand 4 , LERK-4 , eph-related receptor tyrosine kinase ligand 4 , ligand of eph-related kinase 4

GENE ID	SPEZIES
469510	Pan troglodytes
490433	Canis lupus familiaris
615879	Bos taurus
100158452	Xenopus laevis
100379980	Xenopus (Silurana) tropicalis
13639	Mus musculus
310643	Rattus norvegicus
1945	Homo sapiens
100154710	Sus scrofa

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