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MAT2A expression is upregulated through mRNA stabilization upon SAM (zeige TTN Proteine) depletion.
Increased MAT2A expression is associated with recurrence in hepatocellular carcinoma.
High MAT2A expression is associated with tamoxifen-resistant breast cancer.
METTL16 (zeige METTL16 Proteine) that controls MAT2A intron retention in response to intracellular SAM (zeige TTN Proteine) levels; splicing of the MAT2A retained intron is rapidly induced upon Met depletion, and this effect requires a conserved hairpin which is a METTL16 (zeige METTL16 Proteine) m6A (zeige GPM6A Proteine) substrate.
S-adenosyl-L-methionine (zeige AS3MT Proteine) diminishes hepatitis C virus expression by altering MAT1A (zeige MAT1A Proteine)/2A signaling in hepatocytes.
methionine adenosyltransferase II alpha (MAT2A), and the arginine methyltransferase, PRMT5 (zeige PRMT5 Proteine), as vulnerable enzymes in cells with MTAP (zeige MTAP Proteine) deletion.
acet (zeige EP300 Proteine)ylation decreased in hepatocellular cancer
The data presented here support the conclusion that rare genetic variants in MAT2A predispose individuals to thoracic aortic disease.
Results suggest that MAT2A is downregulated in cancer tissues of renal cell carcinomas patients and has function of tumor suppressor though repressing the expression of heme oxygenase-1 (zeige HMOX1 Proteine).
Liver-specific isoenzyme MAT1A (zeige MAT1A Proteine) is genetically linked with an inborn metabolic disorder of hypermethioninemia, as well as a ubiquitously expressed isoenzyme MAT2A, whose enzymatic activity is regulated by an associated subunit MAT2B (zeige MAT2B Proteine).
SIRT1 (zeige SIRT1 Proteine) knock-out embryos display reduced Mat2a expression and histone methylation and are sensitive to maternal methionine restriction-induced lethality, whereas maternal methionine supplementation increases the survival of SIRT1 (zeige SIRT1 Proteine) knock-out newborn mice.
P300 (zeige NOTCH1 Proteine) acetylates MAT IIalpha at lysine residue 81 and destabilizes MAT IIalpha by promoting its ubiquitylation and subsequent proteasomal degradation.
MATIIalpha represses the expression of cyclooxygenase 2 (COX-2 (zeige PTGS2 Proteine)), encoded by Ptgs2 (zeige PTGS2 Proteine), by specifically interacting with histone H3K9 methyltransferase SETDB1 (zeige SETDB1 Proteine).
Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf (zeige MAF Proteine) oncoprotein
MAT2A and MAT2beta (zeige MAT2B Proteine) genes are induced during hepatic stellate cell activation
up-regulation of MAT2A also provides a growth advantage and s-adenosylmethionine and methylthioadenosine can block mitogenic signaling in colon cancer cells.
The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes.
, S-adenosylmethionine synthase isoform type-2
, adoMet synthase 2
, adoMet synthetase 2
, methionine adenosyltransferase 2
, S-adenosylmethionine synthetase isoform type-2
, non-hepatic-type S-adenosylmethionine synthetase
, methionine adenosyltransferase II, alpha
, S-adenosylmethionine synthetase isoform type-2-like
, S-adenosylmethionine synthase
, S-adenosylmethionine synthetase isoform type 2