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The simultaneous downregulation of MAT1A and upregulation of MAT2A are necessary and sufficient for hepatocellular carcinoma metastasis in the process of M1-M2 switch.
MAT2A expression is upregulated through mRNA stabilization upon SAM depletion.
Increased MAT2A expression is associated with recurrence in hepatocellular carcinoma.
High MAT2A expression is associated with tamoxifen-resistant breast cancer.
METTL16 that controls MAT2A intron retention in response to intracellular SAM levels; splicing of the MAT2A retained intron is rapidly induced upon Met depletion, and this effect requires a conserved hairpin which is a METTL16 m6A substrate.
S-adenosyl-L-methionine diminishes hepatitis C virus expression by altering MAT1A/2A signaling in hepatocytes.
methionine adenosyltransferase II alpha (MAT2A), and the arginine methyltransferase, PRMT5, as vulnerable enzymes in cells with MTAP deletion.
crystal structures of human MATalpha2 containing various bound ligands.
acetylation decreased in hepatocellular cancer
Mutagenesis of MATalpha2 and MATbeta phospho-sites destabilized them and prevented hepatic stellate cell trans-differentiation.
The data presented here support the conclusion that rare genetic variants in MAT2A predispose individuals to thoracic aortic disease.
Results suggest that MAT2A is downregulated in cancer tissues of renal cell carcinomas patients and has function of tumor suppressor though repressing the expression of heme oxygenase-1.
Liver-specific isoenzyme MAT1A is genetically linked with an inborn metabolic disorder of hypermethioninemia, as well as a ubiquitously expressed isoenzyme MAT2A, whose enzymatic activity is regulated by an associated subunit MAT2B.
Differential gene expression of BACE1 and PSEN1 in the knockdown cells, which is possibly a consequence of MAT2A deregulation and may indicate a self regulatory mechanism.
we found for the first time a post-transcriptional regulation of MAT1A and MAT2A by AUF1 and HuR in hepatocellular carcinoma.
hypoxia-induced MAT2A expression is HIF-1alpha dependent
Insulin-like growth factor 1 (IGF1) activates methionine adenosyltransferase 2A MAT2A) transcription by both known and novel pathways in colon cancer cells.
X protein of hepatitis B virus inhibits apoptosis in hepatoma cells through enhancing the methionine adenosyltransferase 2A gene expression and reducing S-adenosylmethionine production
Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein
regulation of expression in hepatocarcinoma cells by L-methionine availability
SIRT1 knock-out embryos display reduced Mat2a expression and histone methylation and are sensitive to maternal methionine restriction-induced lethality, whereas maternal methionine supplementation increases the survival of SIRT1 knock-out newborn mice.
P300 acetylates MAT IIalpha at lysine residue 81 and destabilizes MAT IIalpha by promoting its ubiquitylation and subsequent proteasomal degradation.
MATIIalpha represses the expression of cyclooxygenase 2 (COX-2), encoded by Ptgs2, by specifically interacting with histone H3K9 methyltransferase SETDB1.
MAT2A and MAT2beta genes are induced during hepatic stellate cell activation
up-regulation of MAT2A also provides a growth advantage and s-adenosylmethionine and methylthioadenosine can block mitogenic signaling in colon cancer cells.
These results suggest the critical involvement of MAT2A in the periconceptional period in life-long programming of health and disease as well as successful preimplantation development.
The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes.
, S-adenosylmethionine synthase isoform type-2
, adoMet synthase 2
, adoMet synthetase 2
, methionine adenosyltransferase 2
, S-adenosylmethionine synthetase isoform type-2
, non-hepatic-type S-adenosylmethionine synthetase
, methionine adenosyltransferase II, alpha
, S-adenosylmethionine synthetase isoform type-2-like
, S-adenosylmethionine synthase
, S-adenosylmethionine synthetase isoform type 2