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this study suggested that CTGF antibody protected podocytes against injury in DN mice by reducing beta-catenin (zeige CTNNB1 Proteine) overexpression and preventing podocyte EMT (zeige ITK Proteine), which might provide new insight into the mechanism of CTGF inhibition in the treatment of DN.
LPA-LPA1 (zeige LPAR1 Proteine) signaling initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor.
Down-regulation of CTGF is effective in inhibiting postoperative scarring in vivo. This suggests that RNAi with CTGF siRNA may potentially pave the road for a novel therapeutic strategy to improve glaucoma surgery results.
CTGF role in cardiac fibrosis. Long noncoding RNA H19 (zeige NCKAP1 Proteine) mediates CTGF expression.
Notch1 (zeige NOTCH1 Proteine) haploinsufficiency decreased the expression of Ctgf in the aorta and in vitro cell culture system. In vitro studies on SMCs using the Notch1 (zeige NOTCH1 Proteine) intracellular domain (NICD (zeige NOTCH1 Proteine)) plasmid, dominant negative mastermind-like (dnMAML), or specific siRNA suggest that Notch1 (zeige NOTCH1 Proteine), not Notch3 (zeige NOTCH3 Proteine), directly modulates the expression of CTGF
these findings show that cardiac ERK1/2 activity is modulated in part by TGF-b/Smad (zeige SMAD1 Proteine) signaling, leading to altered activation of CTGF/CCN2 to mediate fibrosis and alter cardiac function. This identifies a novel mechanism in the development of LMNA (zeige LMNA Proteine) cardiomyopathy.
the mechanistic target of rapamycin (mTOR (zeige FRAP1 Proteine)) pathway in neurons regulates CTGF production and secretion, revealing a paracrine mechanism by which neuronal signaling regulates oligodendrocyte maturation and myelination in tuberous sclerosis complex (TSC (zeige SLC12A3 Proteine)).
CCN2 suppression by miR (zeige MLXIP Proteine)-199a-5p accounts, in part, for low-level fibrogenic gene expression in quiescent hepatic stellate cells (HSCs) and causes dampened gene expression in activated HSCs after horizontal transfer of miR (zeige MLXIP Proteine)-199a-5p in exosomes from quiescent HSCs.
In summary, our data suggest that in obstructive nephropathy atrophy increases and fibrosis decreases with age and that this relates to increased BMP signaling, most likely due to higher BMP6 (zeige BMP6 Proteine) and lower CTGF expression.
Overexpression of CTGF in cardiomyocytes attenuates left ventricular hypertrophy in angiotensin II induced hypertension.
the up-regulation of CTGF expression by visfatin (zeige NAMPT Proteine) might be mediated via HIF-1a (zeige HIF1A Proteine) -dependent pathway, but not the TGF-b1 pathway in EAHy926 cells
Data suggested that the co-expression of the Hippo transducers TAZ (zeige TAZ Proteine)/YAP (zeige YAP1 Proteine) and CTGF may be an adverse prognostic factor in male breast cancer.
These findings suggest that 5-HT (zeige DDC Proteine) promotes CCN2 production through the 5-HT2AR in growth plates, and that it represses CCN2 production through the 5-HT2BR in articular cartilage for harmonized development of long bones
In addition to well-known anti-inflammatory features, glucocorticoids may have adverse effects on long-term remodeling by TGF-beta1 (zeige TGFB1 Proteine)-independent induction of CTGF in lung cells. Simultaneous treatment with caffeine may attenuate glucocorticoid-induced expression of CTGF, thereby promoting restoration of lung homeostasis.
CytoD modified MKL1, a coactivator of serum response factor (SRF) regulating CTGF induction, and promoted its nuclear localization.
CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers.
In lesional SSc (zeige CYP11A1 Proteine) dermal fibroblasts, GKT-137831 reduced alpha-SMA (zeige SMN1 Proteine) and CCN2 protein overexpression and collagen gel contraction
High glucose-induced cytoplasmic translocation of Dnmt3a (zeige DNMT3A Proteine) contributes to CTGF hypo-methylation in mesangial cells.
Results demonstrat that GDF8 (zeige MSTN Proteine) stimulates the expression and secretion of CTGF in human granulosa cells and provide evidence that both proteins may play critical roles in the regulation of extracellular matrix formation in these cells.
combined inhibition of ALK5 (zeige TGFBR1 Proteine) and CTGF is required to prevent TGFbeta (zeige TGFB1 Proteine)-induced nodule formation in tri (zeige VANGL2 Proteine)-cellular cultures
The results indicate that CTGF suppresses the synthesis of biglycan (zeige BGN Proteine) but newly induced that of decorin (zeige DCN Proteine) in the cells when the cell density is low.
Actin cytoskeleton-dependent regulation of CTGF transcription and mRNA stability
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
this study reveals that CTGF is necessary and sufficient to stimulate glial bridging and natural spinal cord regeneration.
CTGF/CCN2 plays an important role in notochord development and is required for general embryonic development
Recombinant CTGF added to embryonic mouse neural precursor cell culture increased the number of Sox-2 (zeige SOX2 Proteine)-, GFAP (zeige GFAP Proteine)-and GFAP (zeige GFAP Proteine)/Nestin (zeige NES Proteine)-positive cells, activated p44 (zeige GTF2H2 Proteine)/42 signaling, and upregulated fibronectin (zeige FN1 Proteine). In human glioma cells, it induced GFAP (zeige GFAP Proteine) and nestin (zeige NES Proteine).
Data show that connective-tissue growth factor regulates signalling through the Wnt (zeige WNT2 Proteine) pathway, in accord with its ability to bind to the Wnt (zeige WNT2 Proteine) co-receptor LDL receptor (zeige LDLR Proteine)-related protein 6 (LRP6 (zeige LRP6 Proteine)).
These data suggest that CTGF levels are increased in multiple organs after radiation exposure and that inflammatory cell infiltration may contribute to the elevated levels of CTGF in multiple organs.
A significant increase in TGF-beta1 (zeige TGFB1 Proteine) and CTGF was found at 6 weeks in the subsynovial connective tissue in a rabbit model of carpal tunnel syndrome.
Stretch is an important primary trigger for CTGF-induction in the overloaded heart.
Connective tissue growth factor is expressed in the naive cornea, lens, iris, and retina, and is expressed immediately after epithelial injury. Loss of CTGF impairs efficient re-epithelialization of corneal wounds.
TGF-beta1 (zeige TGFB1 Proteine) can inhibit the growth of urethra epithelium cells and induce the expression of CTGF.
Overexpression of CTGF in the blebs after trabeculectomy demonstrates that CTGF may play an important role in the process of wound healing.
CCN2 was transiently expressed at the leading keratinocyte edge in wound healing.
Atrial fibrillation patients and animals exhibited a significantly increased expression of connective tissue growth factor (CTGF). Angiotension II-induced CTGF expression might be involved in atrial substrate remodeling.
CTGF in trabecular meshwork is modulated by physiological agonists and by increased ocular pressure and mechanical stretch. Regulation of CTGF within outflow pathway may play role in homeostasis of intraocular pressure.
CTGF level was not altered in model of obliterative bronchiolitis.
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
CCN family member 2
, Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24)
, fibroblast inducible secreated protein
, fibroblast inducible secreted protein
, hypertrophic chondrocyte-specific gene product 24
, hypertrophic chondrocyte-specific protein 24
, IGF-binding protein 8
, insulin-like growth factor-binding protein 8
, connective tissue growth-related protein
, connective tissue growth factor
, connective tissue growth factor XCTGF
, Connective tissue growth factor
, connective tissue growth factor-like