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early myocardial CTGF mRNA expression (six hours) after Ang-II (zeige AGT Proteine) exposure is likely dependent on latent TGF-beta (zeige TGFB1 Proteine) activation via the canonical Smad (zeige SMAD1 Proteine)-dependent pathway in resident cardiac cells.
These results indicate that the hepatocytic expression of TGF-beta (zeige TGFB1 Proteine) and CTGF is mediated by Wnt (zeige WNT2 Proteine) signalling in Schistosoma japonicum infection.
Data (including data from studies using transgenic mice) suggest that Ctgf secreted from vascular endothelium in pancreas plays critical role in up-regulation of insulin (zeige INS Proteine) secretion in pancreatic beta-cells during pregnancy; here, pregnant mice with global Ctgf haplo-insufficiency (heterozygous for loss-of-function mutation) (a) exhibit impairment in maternal beta-cell proliferation and (b) develop gestational diabetes.
The data demonstrate that MMP13 (zeige MMP13 Proteine) and CTGF play a crucial role in modulation of fibrogenic mediators while promoting hepatic fibrogenesis.
p-SMAD2 (zeige SMAD2 Proteine)/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 (zeige TGFB1 Proteine) induced CTGF exp p-SMAD2 (zeige SMAD2 Proteine)/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 (zeige TGFB1 Proteine) induced CTGF expression during tooth development.
Ctgf is the direct target gene of SOX9 (zeige SOX9 Proteine) in chondrocytes and nucleus pulposus cells.
As shown in mouse model of kidney fibrosis CTGF is significantly involved in fibrosis-associated renal lymphangiog (zeige VEGFC Proteine)enesis through regulation of, and direct interaction with, VEGF-C.
CTGF and BMP2 (zeige BMP2 Proteine) are induced following myocardial ischemia in mice and humans.
this study suggested that CTGF antibody protected podocytes against injury in DN mice by reducing beta-catenin (zeige CTNNB1 Proteine) overexpression and preventing podocyte EMT (zeige ITK Proteine), which might provide new insight into the mechanism of CTGF inhibition in the treatment of DN.
LPA-LPA1 (zeige LPAR1 Proteine) signaling initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor.
Down-regulation of CTGF could markly decrease proliferation.
PVT1 was able to bind and degrade miR26b to promote connective tissue growth factor (CTGF) and angiopoietin 2 (ANGPT2 (zeige ANGPT2 Proteine)) expression.
CTGF can reduce glycolysis and mitochondrial OXPHOS pathways by increasing mtTFA (zeige TFAM Proteine) protein degradation and in turn reduces cancer migration and invasion in oral squamous cell carcinoma (OSCC).
Results show that mRNA and serum expression levels of Cyr61 (zeige CYR61 Proteine), CTGF, and VEGF (zeige VEGFA Proteine) in muscle tissues of patients with polymyositis (PM)/dermatomyositis (DM). These data suggest that these genes may be involved in the pathogenesis mainly by affecting the formation of blood vessels and promoting inflammatory response.
This study study discovered a positive feedback loop between CTGF and CCL18 (zeige CCL18 Proteine) in hepatocellular carcinoma metastasis.
Serum connective tissue growth factor (CTGF) is a promising diagnostic biomarker for rheumatoid arthritis (RA).
Connective tissue growth factor (CTGF) is an important mediator of renal allograft fibrosis, and urinary CTGF (CTGFu) levels correlate with the development of allograft interstitial fibrosis. We evaluated the predictive value of CTGF protein expression in 160 kidney transplant recipients with paired protocol biopsies at 3 months and 5 years after transplantation.
Lymphangiogenesis during tubulointerstitial fibrosis to be associated with increased expression of CTGF and VEGF-C (zeige VEGFC Proteine) in human obstructed nephropathy as well as in diabetic kidney disease. vitro, CTGF induced VEGF-C (zeige VEGFC Proteine) production in HK-2 (zeige HK2 Proteine) cells, while CTGF siRNA suppressed transforming growth factor beta1-induced VEGF-C (zeige VEGFC Proteine) upregulation.
miR132 may target CTGF in regulating fibrosis in Ang (zeige ANG Proteine) IItreated cardiac fibroblasts.
CTGF-mediated temozolomide resistance in glioblastoma operates through TGF-beta1 (zeige TGFB1 Proteine)-dependent activation of Smad (zeige SMAD1 Proteine)/ERK (zeige EPHB2 Proteine) signaling pathways
Results confirm the prodevelopmental actions of activin A (zeige INHBA Proteine) and indicate that CTGF may also function as an embryokine by regulating the number of ICM cells in the blastocyst and altering gene expression. Low concentrations of HGF (zeige HGF Proteine) were inhibitory to development.
The results indicate that CTGF suppresses the synthesis of biglycan (zeige BGN Proteine) but newly induced that of decorin (zeige DCN Proteine) in the cells when the cell density is low.
Actin cytoskeleton-dependent regulation of CTGF transcription and mRNA stability
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
this study reveals that CTGF is necessary and sufficient to stimulate glial bridging and natural spinal cord regeneration.
CTGF/CCN2 plays an important role in notochord development and is required for general embryonic development
Recombinant CTGF added to embryonic mouse neural precursor cell culture increased the number of Sox-2 (zeige SOX2 Proteine)-, GFAP (zeige GFAP Proteine)-and GFAP (zeige GFAP Proteine)/Nestin (zeige NES Proteine)-positive cells, activated p44 (zeige GTF2H2 Proteine)/42 signaling, and upregulated fibronectin (zeige FN1 Proteine). In human glioma cells, it induced GFAP (zeige GFAP Proteine) and nestin (zeige NES Proteine).
Data show that connective-tissue growth factor regulates signalling through the Wnt (zeige WNT2 Proteine) pathway, in accord with its ability to bind to the Wnt (zeige WNT2 Proteine) co-receptor LDL receptor (zeige LDLR Proteine)-related protein 6 (LRP6 (zeige LRP6 Proteine)).
These data suggest that CTGF levels are increased in multiple organs after radiation exposure and that inflammatory cell infiltration may contribute to the elevated levels of CTGF in multiple organs.
A significant increase in TGF-beta1 (zeige TGFB1 Proteine) and CTGF was found at 6 weeks in the subsynovial connective tissue in a rabbit model of carpal tunnel syndrome.
Stretch is an important primary trigger for CTGF-induction in the overloaded heart.
Connective tissue growth factor is expressed in the naive cornea, lens, iris, and retina, and is expressed immediately after epithelial injury. Loss of CTGF impairs efficient re-epithelialization of corneal wounds.
TGF-beta1 (zeige TGFB1 Proteine) can inhibit the growth of urethra epithelium cells and induce the expression of CTGF.
Overexpression of CTGF in the blebs after trabeculectomy demonstrates that CTGF may play an important role in the process of wound healing.
CCN2 was transiently expressed at the leading keratinocyte edge in wound healing.
Atrial fibrillation patients and animals exhibited a significantly increased expression of connective tissue growth factor (CTGF). Angiotension II-induced CTGF expression might be involved in atrial substrate remodeling.
CTGF in trabecular meshwork is modulated by physiological agonists and by increased ocular pressure and mechanical stretch. Regulation of CTGF within outflow pathway may play role in homeostasis of intraocular pressure.
CTGF level was not altered in model of obliterative bronchiolitis.
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
CCN family member 2
, Connective tissue growth factor precursor (CTGF) (FISP-12 protein) (Hypertrophic chondrocyte-specific protein 24)
, fibroblast inducible secreated protein
, fibroblast inducible secreted protein
, hypertrophic chondrocyte-specific gene product 24
, hypertrophic chondrocyte-specific protein 24
, IGF-binding protein 8
, insulin-like growth factor-binding protein 8
, connective tissue growth-related protein
, connective tissue growth factor
, connective tissue growth factor XCTGF
, Connective tissue growth factor
, connective tissue growth factor-like