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Human HLAG Protein expressed in HEK-293 Cells - ABIN2722837
Hodge, Lourensz, Vaghjiani, Nguyen, Tchongue, Wang, Murthi, Sievert, Manuelpillai: Soluble factors derived from human amniotic epithelial cells suppress collagen production in human hepatic stellate cells. in Cytotherapy 2014
The findings indicate that GPER (zeige GPER Proteine)/miR148a/HLAG signaling pathway may mediates the development of ovarian endometriosis and may become a potential therapeutic target for the treatment of endometriosis.
Significantly different distribution of HLA-G polymorphism (rs1611715), but not the serum level of sHLA-G, were found between multiple sclerosis patients and healthy individuals.
These results indicate the importance of the HLA-G promoter SNPs in the pregnancy outcome. But to reach a more definite conclusion, subsequent studies on 3' UTR and other positions with polymorphism in the 5' UTR regions larger samples are necessary.
HLA-G expression is associated with poor survival in stage III gastric cancer patients and represents a possible immunoescape mechanism of cancer cells.
this study shows that HLA-G molecules have a role in predicting the newborn's likelihood for oral HPV infection at birth.
HLA-G is highly represented in ovarian carcinoma suggesting a potential association with progressive disease mechanism
this study shows that HLA-G is expressed in intestinal samples of ulcerative colitis and Crohn's disease patients
this study shows that HLA-G mediated immune regulation is impaired by a single amino acid exchange in the alpha 2 domain
No significant differences in single nucleotide polymorphisms in the 3' untranslated region of HLA-G in placentas between spontaneous preterm birth and preeclampsia.
the HLA-G 14bp ins/del gene polymorphism is an important risk factor for the incidence and poor outcome of NHL cases.
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.
HLA G antigen
, HLA class I histocompatibility antigen, alpha chain G
, HLA class I molecule
, HLA-G histocompatibility antigen, class I, G
, MHC class I antigen G
, b2 microglobulin
, B-F minor
, MHC class I antigen alpha chain
, MHC class I glycoprotein
, major histocompatibility complex, class I, G