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Human HLAG Protein expressed in HEK-293 Cells - ABIN2722837
Hodge, Lourensz, Vaghjiani, Nguyen, Tchongue, Wang, Murthi, Sievert, Manuelpillai: Soluble factors derived from human amniotic epithelial cells suppress collagen production in human hepatic stellate cells. in Cytotherapy 2014
The 14 bp allele of HLA-G sharing between the partners did not show any significant association with the number of miscarriages in recurrent miscarriage couples.
During a successful pregnancy, HLA-G expression is elevated in term placentas from women with a history of recurrent miscarriage as compared to controls, despite a genetic predisposition that is associated with decreased HLA-G levels.
Under hypoxia, using siRNA technology to down-regulate the expression of HLA-G may affect the proliferation and invasion ability of trophoblast cells, which may be involved in the occurrence of hypertensive disorder of pregnancy.
the +3010C/G and +3142C/G HLA-G 3'UTR variation sites were differentially associated according to asthma severity.
Our results, based on a multicenter cohort, thus support the pertinence of HLA-G haplotypes as predictive genetic markers for asthma
The HLA-G 3'UTR 14-bp ins/del was not associated with either HIV nor HIV/HPV co-infection. The +3142G allele (p = 0.049) and +3142GG genotype (p = 0.047) were overrepresented in all HIV-infected women. On the other hand, the +3187G allele (p = 0.028) and the +3187GG genotype (p = 0.026) predominated among healthy women.
Serum sHLA-G values were significantly increased in both - patients on the waiting list for the first transplantation and patients who returned in the list, as compared to control group.
Higher scores of Childhood Autism Rating Scale (CARS) and Autistic Core Behavior were found in KIR2DS1-C2+/HLA-G *14bp+Autism Spectrum Disorders children (43.7 +/- 1.5, p = 0.03; 3.3 +/- 0.1, p = 0.03, respectively). These results suggested a synergistic polygenic association of KIR2DS1-HLAC2+/HLA-G *14bp+ pattern with behavioral impairment in Autism Spectrum Disorders children.
High HLA-G expression is associated with Oral Squamous Cell Carcinoma.
cytokines and soluble HLA-G play an essential role in marrow T-ALL microenvironment during chemotherapy, especially the immunosuppressive cytokine IL-10 which can be used as biomarker of disease outcome
HLA-G, NRP1, and PD-1, may be involved in the immune response in psoriatic patients
Considering that others 14-bp associations were inconclusive and that other variation sites observed at HLA-G 3'UTR exhibit a proven role on post-transcriptional regulation of HLA-G expression, the complete 3'UTR segment should be analyzed in terms of disease susceptibility, instead of a single polymorphism.
study demonstrated that HLA-G 14-bp Ins/Del polymorphism may exert no influence on susceptibility to viruses - Meta-analysis
The findings indicate that GPER/miR148a/HLAG signaling pathway may mediates the development of ovarian endometriosis and may become a potential therapeutic target for the treatment of endometriosis.
Significantly different distribution of HLA-G polymorphism (rs1611715), but not the serum level of sHLA-G, were found between multiple sclerosis patients and healthy individuals.
These results indicate the importance of the HLA-G promoter SNPs in the pregnancy outcome. But to reach a more definite conclusion, subsequent studies on 3' UTR and other positions with polymorphism in the 5' UTR regions larger samples are necessary.
HLA-G expression is associated with poor survival in stage III gastric cancer patients and represents a possible immunoescape mechanism of cancer cells.
this study shows that HLA-G molecules have a role in predicting the newborn's likelihood for oral HPV infection at birth.
HLA-G is highly represented in ovarian carcinoma suggesting a potential association with progressive disease mechanism
this study shows that HLA-G is expressed in intestinal samples of ulcerative colitis and Crohn's disease patients
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.
HLA G antigen
, HLA class I histocompatibility antigen, alpha chain G
, HLA class I molecule
, HLA-G histocompatibility antigen, class I, G
, MHC class I antigen G
, b2 microglobulin
, B-F minor
, MHC class I antigen alpha chain
, MHC class I glycoprotein
, major histocompatibility complex, class I, G