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Human HLAG Protein expressed in HEK-293 Cells - ABIN2722837
Hodge, Lourensz, Vaghjiani, Nguyen, Tchongue, Wang, Murthi, Sievert, Manuelpillai: Soluble factors derived from human amniotic epithelial cells suppress collagen production in human hepatic stellate cells. in Cytotherapy 2014
study highlights the association of elevated sHLA-G levels with less severe acute and chronic GvHD and provides additional functional analyses elucidating possible tolerance-inducing mechanisms of sHLA-G in the context of allo-SCT.
Embryo HLA-G secretion before implantation is associated with pregnancy rate.
These results suggest that the risk of complications in pregnancy is influenced by the HLA-G 10101, HLA-G 10108, and HLA-G 10106 alleles and is not influenced by the 14-bp ins/del polymorphism in the 3'UTR of the HLA-G gene.
Human leukocyte antigen-G (HLA-G) plays an important role in the development of human cancers. Several published studies have investigated the relationship between the HLA-G +3142 C>G (rs1063320) polymorphism and cancer susceptibility in different populations.
this study shows that in systemic sclerosis the secretion and/or shedding of soluble HLA-G molecules and the membrane expression of HLA-G by peripheral blood mononuclear cells is elevated
these data suggest that HLA-G participates in prevention of graft-versus-host disease
this study shows that HLA-G is associated with the prognosis of oral squamous cell carcinoma
A strong association between HLA-G 14 bp ins/ins genotype and HOMA in obese children and adolescents. This association could be hypothetically modulated by subclinical inflammation.
Findings suggest that presence of "high-expressor" histocompatibility antigen class I G (HLA-G) 14bp Del/Del genotype in schizophrenia patients could attenuate interleukin-6 (IL-6) mediated inflammation in schizophrenia.
Increased HLA-G and IL-10 expression in a group of acral lentiginous melanomas compared with a group of superficial spreading melanomas were related to the histopathological features predictive of unfavorable prognosis in cutaneous melanoma and metastasis.
The 14 bp allele of HLA-G sharing between the partners did not show any significant association with the number of miscarriages in recurrent miscarriage couples.
During a successful pregnancy, HLA-G expression is elevated in term placentas from women with a history of recurrent miscarriage as compared to controls, despite a genetic predisposition that is associated with decreased HLA-G levels.
Under hypoxia, using siRNA technology to down-regulate the expression of HLA-G may affect the proliferation and invasion ability of trophoblast cells, which may be involved in the occurrence of hypertensive disorder of pregnancy.
the +3010C/G and +3142C/G HLA-G 3'UTR variation sites were differentially associated according to asthma severity.
Our results, based on a multicenter cohort, thus support the pertinence of HLA-G haplotypes as predictive genetic markers for asthma
The HLA-G 3'UTR 14-bp ins/del was not associated with either HIV nor HIV/HPV co-infection. The +3142G allele (p = 0.049) and +3142GG genotype (p = 0.047) were overrepresented in all HIV-infected women. On the other hand, the +3187G allele (p = 0.028) and the +3187GG genotype (p = 0.026) predominated among healthy women.
Serum sHLA-G values were significantly increased in both - patients on the waiting list for the first transplantation and patients who returned in the list, as compared to control group.
Higher scores of Childhood Autism Rating Scale (CARS) and Autistic Core Behavior were found in KIR2DS1-C2+/HLA-G *14bp+Autism Spectrum Disorders children (43.7 +/- 1.5, p = 0.03; 3.3 +/- 0.1, p = 0.03, respectively). These results suggested a synergistic polygenic association of KIR2DS1-HLAC2+/HLA-G *14bp+ pattern with behavioral impairment in Autism Spectrum Disorders children.
High HLA-G expression is associated with Oral Squamous Cell Carcinoma.
cytokines and soluble HLA-G play an essential role in marrow T-ALL microenvironment during chemotherapy, especially the immunosuppressive cytokine IL-10 which can be used as biomarker of disease outcome
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.
HLA G antigen
, HLA class I histocompatibility antigen, alpha chain G
, HLA class I molecule
, HLA-G histocompatibility antigen, class I, G
, MHC class I antigen G
, b2 microglobulin
, B-F minor
, MHC class I antigen alpha chain
, MHC class I glycoprotein
, major histocompatibility complex, class I, G