Macrophage Scavenger Receptor 1 Protein (MSR1) (His tag)

Produktnummer ABIN7534675

Produktdetails

Target: Macrophage Scavenger Receptor 1 (MSR1)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Macrophage Scavenger Receptor 1 Protein ist gelabelt mit His tag.

Verwendungszweck: Active Recombinant Human MSR1/CD204 Protein

Sequenz: KWETKNCSVS STNANDITQS LTGKGNDSEE EMRFQEVFME HMSNMEKRIQ HILDMEANLM DTEHFQNFSM TTDQRFNDIL LQLSTLFSSV QGHGNAIDEI SKSLISLNTT LLDLQLNIEN LNGKIQENTF KQQEEISKLE ERVYNVSAEI MAMKEEQVHL EQEIKGEVKV LNNITNDLRL KDWEHSQTLR NITLIQGPPG PPGEKGDRGP TGESGPRGFP GPIGPPGLKG DRGAIGFPGS RGLPGYAGRP GNSGPKGQKG EKGSGNTLTP FTKVRLVGGS GPHEGRVEIL HSGQWGTICD DRWEVRVGQV VCRSLGYPGV QAVHKAAHFG QGTGPIWLNE VFCFGRESSI EECKIRQWGT RACSHSEDAG VTCTL

Spezifität: Lys77-Leu451

Reinheit: > 90 % by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: < 0.1 EU/μg of the protein by LAL method.

Biological Activity Comment: 1.Measured by its binding ability in a functional ELISA.Immobilized Human MSR1 Protein at 1μg/mL (100 μL/well) can bind MSR1 Rabbit pAb with a linear range of 0.76-2.88 ng/mL.|2.Measured by its binding ability in a functional ELISA. Immobilized Human A-I/APOA1 at 5μg/mL (100 μL/well) can bind Human MSR1/CD204 with a linear range of 1-49.4ng/mL.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Antigendetails

Target: Macrophage Scavenger Receptor 1 (MSR1)

Andere Bezeichnung: MSR1/CD204 (MSR1 Produkte)

Synonyme: CD204 Protein, SCARA1 Protein, SR-A Protein, SRA Protein, phSR1 Protein, phSR2 Protein, MRS-A Protein, MSR Protein, MSR-A Protein, SR-AI Protein, SR-AII Protein, Scara1 Protein, Scvr Protein, MSR1 Protein, RGD1564316 Protein, macrophage scavenger receptor 1 Protein, scavenger receptor class A member 5 Protein, MSR1 Protein, Msr1 Protein, SCARA5 Protein

Hintergrund:

Description: This protein is the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

Name: CD204, SCARA1, SR-A, SR-AI, SR-AII, SR-AIII, SRA, phSR1, phSR2,MSR1,SCARA1,SR-A,SR-AI,SR-AII,SR-AIII,SRA,phSR1,phSR2

Gen-ID: 4481

UniProt: P21757