LILRB3 Protein (His tag,AVI tag)

Produktnummer ABIN7520278

Produktdetails

Target: LILRB3 (Leukocyte Immunoglobulin-Like Receptor B3 (LILRB3))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses LILRB3 Protein ist gelabelt mit His tag,AVI tag.

Verwendungszweck: Recombinant Human LILRB3/ILT-5/CD85a Protein

Sequenz: GPFPKPTLWA EPGSVISWGS PVTIWCQGSQ EAQEYRLHKE GSPEPLDRNN PLEPKNKARF SIPSMTEHHA GRYRCHYYSS AGWSEPSDPL EMVMTGAYSK PTLSALPSPV VASGGNMTLR CGSQKGYHHF VLMKEGEHQL PRTLDSQQLH SRGFQALFPV GPVTPSHRWR FTCYYYYTNT PWVWSHPSDP LEILPSGVSR KPSLLTLQGP VLAPGQSLTL QCGSDVGYNR FVLYKEGERD FLQRPGQQPQ AGLSQANFTL GPVSPSNGGQ YRCYGAHNLS SEWSAPSDPL NILMAGQIYD TVSLSAQPGP TVASGENVTL LCQSWWQFDT FLLTKEGAAH PPLRLRSMYG AHKYQAEFPM SPVTSAHAGT YRCYGSYSSN PHLLSHPSEP LELVVSGHSG GSSLPPTGPP STPGLGRYLE

Spezifität: Gly24-Glu443

Reinheit: > 95 % by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: <1EU/μg

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store the lyophilized protein at -20°C to -80°C for long term.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Antigendetails

Target: LILRB3 (Leukocyte Immunoglobulin-Like Receptor B3 (LILRB3))

Andere Bezeichnung: LILRB3/ILT-5/CD85a (LILRB3 Produkte)

Synonyme: CD85A Protein, HL9 Protein, ILT-5 Protein, ILT5 Protein, LILRA6 Protein, LIR-3 Protein, LIR3 Protein, PIRB Protein, Gp91 Protein, Lilrb3 Protein, PIR-B Protein, Pirb Protein, NILR-1 Protein, LILRB3 Protein, leukocyte immunoglobulin like receptor B3 Protein, paired Ig-like receptor B Protein, leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 Protein, LILRB3 Protein, Pirb Protein

Hintergrund:

Description: Leukocyte immunoglobulin-like receptor subfamily B member 3, also known as Leukocyte immunoglobulin-like receptor 3, Immunoglobulin-like transcript 5, Monocyte inhibitory receptor HL9, CD85 antigen-like family member A, CD85a and LILRB3, is a single-pass type I membrane protein that belongs to the leukocyte receptor cluster (LRC) present on 19q13.4. LILRB3 / CD85a contains four Ig-like C2-type (immunoglobulin-like) domains. LILRB3 / CD85a contains three copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in the modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. LILRB3 / CD85a is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found.

Name: LILRB3,CD85A,HL9,ILT-5,ILT5,LILRA6,LIR-3,LIR3,PIR-B,PIRB

Gen-ID: 11025

UniProt: O75022