Kallikrein 8 Protein (KLK8) (His tag)

Produktnummer ABIN7534291

Produktdetails

Target: Kallikrein 8 (KLK8)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Kallikrein 8 Protein ist gelabelt mit His tag.

Verwendungszweck: Active Recombinant Human Kallikrein-8/KLK8 Protein

Sequenz: QEDKVLGGHE CQPHSQPWQA ALFQGQQLLC GGVLVGGNWV LTAAHCKKPK YTVRLGDHSL QNKDGPEQEI PVVQSIPHPC YNSSDVEDHN HDLMLLQLRD QASLGSKVKP ISLADHCTQP GQKCTVSGWG TVTSPRENFP DTLNCAEVKI FPQKKCEDAY PGQITDGMVC AGSSKGADTC QGDSGGPLVC DGALQGITSW GSDPCGRSDK PGVYTNICRY LDWIKKIIGS KG

Spezifität: Gln29-Gly260

Reinheit: > 95 % by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: < 0.1 EU/μg of the protein by LAL method.

Biological Activity Comment: Measured by its ability to cleave the fluorogenic peptide substrate Boc-VPR-AMC. The specific activity is >44.95 pmol/min/μg.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of 20 mM Tris,150 mM NaCl, pH 8.0.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Antigendetails

Target: Kallikrein 8 (KLK8)

Andere Bezeichnung: Kallikrein-8/KLK8 (KLK8 Produkte)

Synonyme: HNP Protein, NP Protein, NRPN Protein, PRSS19 Protein, TADG14 Protein, bsp1 Protein, KLK8 Protein, BSP1 Protein, Nrpn Protein, Prss19 Protein, kallikrein related peptidase 8 Protein, kallikrein related-peptidase 8 Protein, KLK8 Protein, Klk8 Protein

Hintergrund:

Description: Kallikrein-8, also known as Neuropsin, Serine protease 19, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein and KLK8, is a secreted protein which belongs to the peptidase S1 family and Kallikrein subfamily. It is a serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Kallikrein-8 / KLK8 is involved in skin desquamation and keratinocyte proliferation and plays a role in the secondary phase of pathogenesis following spinal cord injury. Kallikrein-8 / KLK8 is expressed at high levels in serum, ascites fluid and tumor cytosol of advanced stage ovarian cancer patients and may serve as a marker of ovarian cancer.

Name: KLK8, HNP, NP, NRPN, PRSS19, TADG14, kallikrein-8,Kallikrein 8,HNP,NP,NRPN,PRSS19,TADG14

Gen-ID: 11202

UniProt: O60259

Pathways: Komplementsystem