GFRA1 Protein (Fc Tag,His tag)

Produktnummer ABIN7520038

Produktdetails

Target: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses GFRA1 Protein ist gelabelt mit Fc Tag,His tag.

Verwendungszweck: Active Recombinant Human GDNFR-alpha-1/GFRA1 Protein

Sequenz: AEVSGGDRLD CVKASDQCLK EQSCSTKYRT LRQCVAGKET NFSLASGLEA KDECRSAMEA LKQKSLYNCR CKRGMKKEKN CLRIYWSMYQ SLQGNDLLED SPYEPVNSRL SDIFRVVPFI SVEHIPKGNN CLDAAKACNL DDICKKYRSA YITPCTTSVS NDVCNRRKCH KALRQFFDKV PAKHSYGMLF CSCRDIACTE RRRQTIVPVC SYEEREKPNC LNLQDSCKTN YICRSRLADF FTNCQPESRS VSSCLKENYA DCLLAYSGLI GTVMTPNYID SSSLSVAPWC DCSNSGNDLE ECLKFLNFFK DNTCLKNAIQ AFGNGSDVTV WQPAFPVQTT TATTTTALRV KNKPLGPAGS ENEIPTHVLP PCANLQAQKL KSNVSGNTHL CISNGNYEKE GLGASSHITT K

Spezifität: Ala19-Lys429

Reinheit: > 80 % by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: < 1.0 EU/μg of the protein by LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA. Immobilized Human GDNF at 1 μg/mL (100 μL/well) can bind Human GFRA1 with a linear range of 2-332 ng/mL.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Antigendetails

Target: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Andere Bezeichnung: GDNFR-alpha-1/GFRA1 (GFRA1 Produkte)

Synonyme: gdnfr Protein, ret1l Protein, retl1 Protein, trnr1 Protein, gdnfra Protein, MGC122616 Protein, gfr-alpha-1 Protein, GDNFR Protein, GDNFRA Protein, GFR-ALPHA-1 Protein, RET1L Protein, RETL1 Protein, TRNR1 Protein, GDNFRALPHA Protein, GFRA1 Protein, AU042498 Protein, gfralpha1a Protein, zgc:110129 Protein, GDNF family receptor alpha 1 Protein, glial cell line derived neurotrophic factor family receptor alpha 1 Protein, gdnf family receptor alpha 1a Protein, gfra1 Protein, GFRA1 Protein, Gfra1 Protein, gfra1a Protein

Hintergrund:

Description: This protein is a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.

Name: GFRA1,GDNFR,GDNFRA,GFR-ALPHA-1,RET1L,RETL1,TRNR1

Gen-ID: 2674

UniProt: P56159