EPH Receptor A2 Protein (EPHA2) (His tag)

Produktnummer ABIN7519937

Produktdetails

Target: EPH Receptor A2 (EPHA2)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses EPH Receptor A2 Protein ist gelabelt mit His tag.

Verwendungszweck: Active Recombinant Human EphA2/ECK Protein

Sequenz: QGKEVVLLDF AAAGGELGWL THPYGKGWDL MQNIMNDMPI YMYSVCNVMS GDQDNWLRTN WVYRGEAERI FIELKFTVRD CNSFPGGASS CKETFNLYYA ESDLDYGTNF QKRLFTKIDT IAPDEITVSS DFEARHVKLN VEERSVGPLT RKGFYLAFQD IGACVALLSV RVYYKKCPEL LQGLAHFPET IAGSDAPSLA TVAGTCVDHA VVPPGGEEPR MHCAVDGEWL VPIGQCLCQA GYEKVEDACQ ACSPGFFKFE ASESPCLECP EHTLPSPEGA TSCECEEGFF RAPQDPASMP CTRPPSAPHY LTAVGMGAKV ELRWTPPQDS GGREDIVYSV TCEQCWPESG ECGPCEASVR YSEPPHGLTR TSVTVSDLEP HMNYTFTVEA RNGVSGLVTS RSFRTASVSI NQTEPPKVRL EGRSTTSLSV SWSIPPPQQS RVWKYEVTYR KKGDSNSYNV RRTEGFSVTL DDLAPDTTYL VQVQALTQEG QGAGSKVHEF QTLSPEGSGN

Spezifität: Gln25-Asn534

Reinheit: > 97 % by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: < 0.1 EU/μg of the protein by LAL method.

Biological Activity Comment: Measured by its binding ability in a functional ELISA. Immobilized Human EphA2 at 1 μg/mL (100 μL/well) can bind Human EFNA1 with a linear range of 0.098-4.084 ng/mL.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.

Antigendetails

Target: EPH Receptor A2 (EPHA2)

Andere Bezeichnung: EphA2/ECK (EPHA2 Produkte)

Synonyme: ARCC2 Protein, CTPA Protein, CTPP1 Protein, CTRCT6 Protein, ECK Protein, epha2 Protein, MGC89505 Protein, AW545284 Protein, Eck Protein, Myk2 Protein, Sek-2 Protein, Sek2 Protein, id:ibd5152 Protein, rtk6 Protein, G42 Protein, XE10 Protein, epha2-A Protein, EPH receptor A2 Protein, Eph receptor A2 Protein, epoxide hydrolase Protein, eph receptor A2 a Protein, EPH receptor A2 L homeolog Protein, EPHA2 Protein, Epha2 Protein, epha2 Protein, ephA2 Protein, epha2a Protein, epha2.L Protein

Hintergrund:

Description: Eph receptor A2 (Ephrin type-A receptor 2 or EphA2) is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family.The receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration.

Name: ARCC2,CTPA,CTPP1,CTRCT6,ECK,EPHA2

Gen-ID: 1969

UniProt: P29317

Pathways: RTK Signalweg