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Decorin Protein (DCN) (His tag)

DCN Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % by SDS-PAGE. Active
Produktnummer ABIN7535247
  • Target Alle Decorin (DCN) Proteine anzeigen
    Decorin (DCN)
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Spezies
    • 14
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 8
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses Decorin Protein ist gelabelt mit His tag.
    Verwendungszweck
    Active Recombinant Human Decorin/PG-S2/DCN Protein
    Sequenz
    GPFQQRGLFD FMLEDEASGI GPEVPDDRDF EPSLGPVCPF RCQCHLRVVQ CSDLGLDKVP KDLPPDTTLL DLQNNKITEI KDGDFKNLKN LHALILVNNK ISKVSPGAFT PLVKLERLYL SKNQLKELPE KMPKTLQELR AHENEITKVR KVTFNGLNQM IVIELGTNPL KSSGIENGAF QGMKKLSYIR IADTNITSIP QGLPPSLTEL HLDGNKISRV DAASLKGLNN LAKLGLSFNS ISAVDNGSLA NTPHLRELHL DNNKLTRVPG GLAEHKYIQV VYLHNNNISV VGSSDFCPPG HNTKKASYSG VSLFSNPVQY WEIQPSTFRC VYVRSAIQLG NYK
    Spezifität
    Gly17-Lys359
    Reinheit
    > 95 % by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Biological Activity Comment
    Measured by its binding ability in a functional ELISA. Immobilized Human DCN at 1 μg/mL (100 μL/well) can bind DCN Rabbit pAb with a linear range of 0.5-141 ng/mL.
    Top Product
    Discover our top product DCN Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
    Buffer
    Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Store the lyophilized protein at -20°C to -80°C for long term.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
  • Target
    Decorin (DCN)
    Andere Bezeichnung
    Decorin/PG-S2/DCN (DCN Produkte)
    Synonyme
    CSCD Protein, DSPG2 Protein, PG40 Protein, PGII Protein, PGS2 Protein, SLRR1B Protein, DC Protein, mDcn Protein, cscd Protein, dspg2 Protein, pg40 Protein, pgii Protein, pgs2 Protein, slrr1b Protein, decorin Protein, decorin L homeolog Protein, DCN Protein, Dcn Protein, dcn.L Protein, dcn Protein
    Hintergrund

    Description: Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core protein and a covalently linked glycosaminoglycan chain which is either chondroitin sulfate (CS) or dermatan sulfate (DS). As a component of connective tissue, decorin interacts with several extracellular matrix components, such as type I collagen and fibronectin, and plays a role in matrix assembly. Decorin resides in the tumor microenvironment and affects the biology of various types of cancer by downregulating the activity of several receptors involved in cell growth and survival. Decorin binds to and modulates the signaling of the epidermal growth factor receptor and other members of the ErbB family of receptor tyrosine kinases. It exerts its antitumor activity by a dual mechanism: via inhibition of these key receptors through their physical downregulation coupled with attenuation of their signaling, and by binding to and sequestering TGFbeta. Decorin also modulates the insulin-like growth factor receptor and the low-density lipoprotein receptor-related protein 1, which indirectly affects the TGFbeta receptor pathway. Decorin plays significant roles in tissue development and assembly, as well as playing both direct and indirect signaling roles.

    Name: DCN,CSCD,DSPG2,PG40,PGII,PGS2,SLRR1B,decorin,Decorin

    Gen-ID
    1634
    UniProt
    P07585-1
    Pathways
    Glycosaminoglycan Metabolic Process
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