MICB Protein (AA 1-298) (His tag)
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- Target Alle MICB Proteine anzeigen
- MICB (MHC Class I Polypeptide-Related Sequence B (MICB))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- AA 1-298
- Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses MICB Protein ist gelabelt mit His tag.
- Sequenz
- Met 1-Gly 298
- Produktmerkmale
- A DNA sequence encoding the extracellular domain of human MICB (NP_005922.2) (Met 1-Gly 298) was expressed with a C-terminal polyhistidine tag.
- Reinheit
- >98 % as determined by reducing SDS-PAGE.
- Endotoxin-Niveau
- <1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Immobilized human MICB-His at 10 μg/ml (100 μl/well) can bind human NKG2D, The EC50 of human NKG2D is 0.52-1.2 μg/ml.
- Top Product
- Discover our top product MICB Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4.
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Haltbarkeit
- 12 months
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- Target
- MICB (MHC Class I Polypeptide-Related Sequence B (MICB))
- Andere Bezeichnung
- MICB (MICB Produkte)
- Synonyme
- PERB11.2 Protein, MHC class I polypeptide-related sequence B Protein, MHC class I-related protein-like Protein, MICB Protein, LOC512825 Protein
- Hintergrund
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Background: MHC class I polypeptide-related sequence B, also known as MICB, is a heavily glycosylated protein serving as a ligand for the type II receptor NKG2D. MICB shares 85 % amino acid identity with MICA, a closely related protein, both of which contain three extracellular immunoglobulin-like domains, but without capacity to bind peptide or interact with beta-2-microglobulin. acting as a stress-induced self-antigen, binding of MICB to the NKG2D receptor activates the cytolytic response of natural killer (NK) cells, CD8+αβ T cells, and γδ T cells on which the receptor is expressed. MICA/B are minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B recognition thus is involved in tumor surveillance, viral infections, and autoimmune diseases.
Synonym: PERB11.2
- Molekulargewicht
- 33 kDa
- UniProt
- Q29980
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