RAD51 Protein (AA 2-339) (His tag)

Produktnummer ABIN7505246

Dieses Recombinant RAD51-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für RAD51 Protein (AA 2-339) (His tag) (ABIN7505246)

Target: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 2-339

Aufreinigungstag / Konjugat: Dieses RAD51 Protein ist gelabelt mit His tag.

Sequenz: Ala 2-Asp 339

Produktmerkmale: A DNA sequence encoding the Human Rad51 protein (Q06609) (Ala 2-Asp 339) was expressed with a N-His.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Andere Bezeichnung: Rad51

Hintergrund:

Abbreviation: Rad51

Target Synonym: DNA repair protein RAD51 homolog 1,RAD51, HsRAD51,hRAD51

Background: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.

Molekulargewicht:

Calculated MW: 37.07 kDa

Observed MW: 38 kDa

UniProt: Q06609

Pathways: DNA Reparatur