PBK Protein (AA 1-322) (His tag)

Produktnummer ABIN7504501

Produktdetails

Target: PBK (PDZ Binding Kinase (PBK))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-322

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses PBK Protein ist gelabelt mit His tag.

Verwendungszweck: Human PBK/TOPK Protein

Sequenz: Met1-Val322

Produktmerkmale: Recombinant Human PBK/TOPK Protein is expressed from Baculovirus-Insect Cells with His tag at the C-terminus.It contains Met1-Val322.

Reinheit: > 95 % as determined by Tris-Bis PAGE

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22 μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: PBK (PDZ Binding Kinase (PBK))

Andere Bezeichnung: PBK (PBK Produkte)

Synonyme: PBK Protein, topk Protein, CT84 Protein, Nori-3 Protein, SPK Protein, TOPK Protein, 2810434B10Rik Protein, AW538537 Protein, D14Ertd732e Protein, zgc:92050 Protein, PDZ binding kinase Protein, PDZ binding kinase L homeolog Protein, PBK Protein, pbk Protein, Pbk Protein, pbk.L Protein

Hintergrund: T-lymphokine-activated killer cell-originated protein kinase (TOPK, also known as PDZ-binding kinase or PBK) plays a crucial role in cell cycle regulation and mitotic progression. Abnormal overexpression or activation of TOPK has been observed in many cancers, including colorectal cancer, triple-negative breast cancer, and melanoma, and it is associated with increased development, dissemination, and poor clinical outcomes and prognosis in cancer. Moreover, TOPK phosphorylates p38, JNK, ERK, and AKT, which are involved in many cellular functions, and participates in the activation of multiple signaling pathways related to MAPK, PI3K/PTEN/AKT, and NOTCH1.

Molekulargewicht: 37.61 kDa. Due to glycosylation, the protein migrates to 38-45 kDa based on Tris-Bis PAGE result.