Claudin 18.2 protein (Biotin,His-Avi Tag)
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- Target
- Claudin 18.2
- Protein-Typ
- Recombinant
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Spezies
- Human
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Quelle
- Insektenzellen
- Aufreinigungstag / Konjugat
- Biotin,His-Avi Tag
- Verwendungszweck
- Biotinylated Human Claudin-18.2 Protein, Avitag™,His Tag (Nanodisc)
- Sequenz
- Met 1 - Ala 200
- Produktmerkmale
- Biotinylated Human Claudin-18.2 Protein, Avitag,His Tag is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Ala 200 (Accession # P56856-2).
- Endotoxin-Niveau
- 1.0 EU per μg
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Claudin 18.2 (AA 1-261) (Active) protein-VLP
Spezies: Human Wirt: HEK-293 Cells VLP > 95 % as determined by HPLC ELISA, Func, Imm, SPR Active
Claudin 18.2 (AA 1-261) (Active) protein-VLP (Biotin)Spezies: Human Wirt: HEK-293 Cells VLP > 95 % as determined by HPLC ELISA, Func, Imm, SPR Active
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- Kommentare
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This protein carries an Avi tag (Avitag™) at the N-terminus, followed by a polyhistidine tag. (Biotin,Avi , 10xHis) The protein has a calculated MW of 24.8 kDa.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- 20 mM HEPES, 150 mM NaCl, pH 7.5
- Lagerung
- -80 °C
- Informationen zur Lagerung
- -70°C
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- Target
- Claudin 18.2
- Andere Bezeichnung
- Claudin-18.2
- Hintergrund
- Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.
- Molekulargewicht
- 24.8 kDa
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