Claudin 18.2 protein (His tag,Twin-Strep tag)

Produktnummer ABIN7273363

Produktdetails

Target: Claudin 18.2

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Insektenzellen

Aufreinigungstag / Konjugat: His tag,Twin-Strep tag

Verwendungszweck: Mouse Claudin-18.2 Protein, His,Twin-Strep Tag (active membrane protein)

Sequenz: Met 1 - Thr 203

Produktmerkmale: Mouse Claudin-18.2, His,Twin-Strep Tag (CL2-M5585) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Thr 203 (Accession # P56857-3).

Reinheit: >80 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Applikationshinweise: This protein carries a polyhistidine tag at the N-terminus and a twin strep tag at the C-terminus. The protein has a calculated MW of 26.7 kDa. The protein migrates as 40 kDa under reducing (R) condition due to glycosylation.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 50 mM HEPES, 150 mM NaCl, DDM, CHS, pH 7.5

Lagerung: -80 °C

Informationen zur Lagerung: -70°C

Antigendetails

Target: Claudin 18.2

Andere Bezeichnung: Claudin-18.2 

Hintergrund: Synonyms:Claudin-18.2,CLDN18,Claudin-18,Description:Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.

Molekulargewicht: 26.7 kDa