Adenosine A2a Receptor Protein (ADORA2A)

Produktnummer ABIN7491539

Produktdetails

Target: Adenosine A2a Receptor (ADORA2A)

Protein-Typ: Synthetic

Spezies: Human

Quelle: HEK-293 Cells

Verwendungszweck: Human ADORA2A full length protein-synthetic nanodisc

Produktmerkmale: Full Length Transmembrane Proteins (synthetic Nanodisc)

Anwendungsinformationen

Applikationshinweise:

• Applications for VLPs:
• ELISA
• SPR affinity analysis
• Phage display screening
• Immunization
• Cell based assays
• CAR-T cell screening
• Protein cystal structure analysis

Kommentare:

Synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied in nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0)

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: Adenosine A2a Receptor (ADORA2A)

Andere Bezeichnung: ADORA2A (ADORA2A Produkte)

Synonyme: ADORA2A Protein, adora2a.1 Protein, zgc:194773 Protein, A2aR Protein, ADORA2 Protein, RDC8 Protein, A2AAR Protein, AA2AR Protein, A2ar Protein, ADENO Protein, Adora2l1 Protein, adora2a.2 Protein, zgc:193802 Protein, zgc:193822 Protein, adenosine A2a receptor Protein, adenosine A2a receptor a Protein, adenosine A2a receptor L homeolog Protein, adenosine A2a receptor b Protein, ADORA2A Protein, Adora2a Protein, adora2aa Protein, adora2a.L Protein, adora2a Protein, adora2ab Protein

Hintergrund: A2aR, ADORA2,
Description: RDC8A member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding.

Molekulargewicht: The human full length ADORA2A protein has a MW of 44.7 kDa

UniProt: P29274

Pathways: Neurotrophin Signalübertragung, cAMP Metabolic Process, Synaptic Membrane, Feeding Behaviour, Cancer Immune Checkpoints