RNF43 Protein (Fc Tag)

Produktnummer ABIN7490978

Produktdetails

Target: RNF43 (Ring Finger Protein 43 (RNF43))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses RNF43 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant human RNF43 protein with C-terminal human Fc tag

Spezifität: RNF43 (Glu43-Tyr197) hFc (Glu99-Ala330)

Produktmerkmale: Extracellular Domain Protein

Reinheit: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: RNF43 (Ring Finger Protein 43 (RNF43))

Andere Bezeichnung: RNF43 (RNF43 Produkte)

Synonyme: RNF124 Protein, URCC Protein, 4732452J19Rik Protein, RGD1305204 Protein, ring finger protein 43 Protein, RNF43 Protein, Rnf43 Protein

Hintergrund: RNF124, SSPCS, URCC
Description: The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

Molekulargewicht: predicted molecular mass of 39.4 kDa after removal of the signal peptide. The apparent molecular mass of RNF43-hFc is 40-70 kDa due to glycosylation.

UniProt: Q68DV7

Pathways: WNT Signalweg