ITGAV/ITGB8 Protein (Biotin,His-Avi Tag)

Produktnummer ABIN7316905

Produktdetails

Target: ITGAV/ITGB8 (Integrin alpha V beta 8 (ITGAV/ITGB8))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses ITGAV/ITGB8 Protein ist gelabelt mit Biotin,His-Avi Tag.

Verwendungszweck: Biotinylated Mouse Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein, His,Avitag™&Tag Free

Sequenz: Phe 31 - Val 988 & Gly 22 - Leu 681

Produktmerkmale: Biotinylated Mouse ITGAV&ITGB8 Heterodimer Protein is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 988 & Gly 22 - Leu 681 (Accession # P43406-1 & Q0VBD0-1).

Reinheit: 95,00 %

Endotoxin-Niveau: 1.0 EU per μg

Anwendungsinformationen

Kommentare:

Biotinylated Mouse ITGAV&ITGB8 Heterodimer Protein has a calculated MW of 114.2 kDa (ITGAV) & 77.5 kDa (ITGB8). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and an Avi tag (Avitag™) and subunit ITGB8 contains no tag but a basic tail at the C-terminus.The protein migrates as 80-90 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 50 mM Tris, 150 mM NaCl, pH 7.5

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Antigendetails

Target: ITGAV/ITGB8 (Integrin alpha V beta 8 (ITGAV/ITGB8))

Andere Bezeichnung: Integrin alpha V beta 8 (ITGAV/ITGB8 Produkte)

Hintergrund: Synonyms:Integrin alpha V beta 8,ITGAV&ITGB8,Description:Integrin alpha V beta 8 (ITGAV & ITGB8 or ITGAVB8) is expressed in yolk sac, placenta, brain perivascular astrocytes, Schwann cells, renal glomerular mesangial cells and pulmonary epithelial cells. Unlike other alpha V integrins, ITGAVB8 does not appear to assume different activation states, and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif, including vitronectin, fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP, which releases active TGF-beta. This mechanism differs from that of alpha V beta 6, the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms. Downstream effects of TGF-beta activation include control of cell growth and associated vascularization.

Molekulargewicht: 114.2 kDa | 77.5 kDa