ITGAV/ITGB8 Protein (AA 31-988) (His tag)

Produktnummer ABIN6809904

Produktdetails

Target: ITGAV/ITGB8 (Integrin alpha V beta 8 (ITGAV/ITGB8))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 31-988

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses ITGAV/ITGB8 Protein ist gelabelt mit His tag.

Sequenz: AA 31-988

Reinheit: >95 % as determined by reduced SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 50 mM Tris, 150 mM NaCl, pH 7.5

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Antigendetails

Target: ITGAV/ITGB8 (Integrin alpha V beta 8 (ITGAV/ITGB8))

Andere Bezeichnung: Integrin alpha V beta 8 (ITGAV/ITGB8 Produkte)

Hintergrund: Integrin alpha V beta 8 (ITGAV & ITGB8 or ITGAVB8) is expressed in yolk sac, placenta, brain perivascular astrocytes, Schwann cells, renal glomerular mesangial cells and pulmonary epithelial cells. Unlike other alpha V integrins, ITGAVB8 does not appear to assume different activation states, and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif, including vitronectin, fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP, which releases active TGF-beta. This mechanism differs from that of alpha V beta 6, the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms. Downstream effects of TGF-beta activation include control of cell growth and associated vascularization.

Molekulargewicht: 112.5 kDa (ITGAV) & 77.5 kDa (ITGB8)