ITGAV/ITGB5 Protein (Biotin,His-Avi Tag)

Produktnummer ABIN7316901

Produktdetails

Target: ITGAV/ITGB5 (Integrin alpha V / beta 5 (ITGAV/ITGB5))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses ITGAV/ITGB5 Protein ist gelabelt mit Biotin,His-Avi Tag.

Verwendungszweck: Biotinylated Mouse Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His,Avitag™&Tag Free

Sequenz: Phe 31 - Val 988 & Gly 24 - Asn 719

Produktmerkmale: Biotinylated Mouse ITGAV&ITGB5 Heterodimer Protein, His,Avitag&Tag Free is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 988 & Gly 24 - Asn 719 (Accession # P43406-1 & O70309-1).

Reinheit: 95,00 %

Endotoxin-Niveau: 1.0 EU per μg

Anwendungsinformationen

Kommentare:

Biotinylated Mouse ITGAV&ITGB5 Heterodimer Protein has a calculated MW of 114.2 kDa (ITGAV) & 77.5 kDa (ITGB5). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB5 contains no tag but a basic tail at the C-terminus.The protein migrates as 80-90 kDa (ITGB5) and 125-145 kDa (ITGAV)under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 50 mM Tris, 150 mM NaCl, pH 7.5

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Antigendetails

Target: ITGAV/ITGB5 (Integrin alpha V / beta 5 (ITGAV/ITGB5))

Andere Bezeichnung: Integrin alpha V beta 5 (ITGAV/ITGB5 Produkte)

Hintergrund: Synonyms:Integrin alpha V beta 5,ITGAV&ITGB5,Description:Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.

Molekulargewicht: 114.2 kDa | 81.8 kDa