WISP1 Protein (AA 23-367) (His tag)

Produktnummer ABIN7275850

Produktdetails

Target: WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 23-367

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses WISP1 Protein ist gelabelt mit His tag.

Verwendungszweck: Mouse WISP1 Protein

Sequenz: Thr23-Asn367

Produktmerkmale: Recombinant Mouse WISP1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Thr23-Asn367.

Reinheit: > 95 % as determined by Tris-Bis PAGE

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))

Andere Bezeichnung: WISP1 (WISP1 Produkte)

Synonyme: CCN4 Protein, WISP1c Protein, WISP1i Protein, WISP1tc Protein, WISP-1 Protein, WISP1 Protein, si:ch211-38f10.2 Protein, AW146261 Protein, Elm1 Protein, zgc:172276 Protein, WNT1 inducible signaling pathway protein 1 Protein, WNT1 inducible signaling pathway protein 1a Protein, WNT1-inducible-signaling pathway protein 1-like Protein, WNT1 inducible signaling pathway protein 1b Protein, WISP1 Protein, wisp1a Protein, Wisp1 Protein, LOC100627044 Protein, wisp1b Protein

Hintergrund: The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays crucial roles in promoting malignant growth of glioblastoma (GBM), the most lethal brain tumor. WISP1 is preferentially expressed and secreted by GSCs. Silencing WISP1 markedly disrupts GSC maintenance, reduces tumor-supportive TAMs (M2), and potently inhibits GBM growth. WISP1 signals through Integrin α6β1-Akt to maintain GSCs by an autocrine mechanism and M2 TAMs through a paracrine manner.

Molekulargewicht: 39.4 kDa. Due to glycosylation, the protein migrates to 64-68 kDa based on Tris-Bis PAGE result.

UniProt: O54775

Pathways: WNT Signalweg, Growth Factor Binding