PLAU Protein (AA 21-430) (His tag)

Produktnummer ABIN7275453

Produktdetails

Target: PLAU (Plasminogen Activator, Urokinase (PLAU))

Protein-Typ: Recombinant

Proteineigenschaft: AA 21-430

Spezies: Cynomolgus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses PLAU Protein ist gelabelt mit His tag.

Verwendungszweck: Cynomolgus PLAU/uPA Protein (active form)

Sequenz: Ser21-Leu430

Produktmerkmale: Recombinant Cynomolgus PLAU/uPA Protein (active form) is expressed from HEK293 with His tag at the C-Terminus.It contains Ser21-Leu430, which consists of two chains: Long chain A and chain B. The long chain A is further cleaved to yield a short chain A and N-Terminus fragment.

Reinheit: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Biological Activity Comment: The affinity constant of 0.033 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: PLAU (Plasminogen Activator, Urokinase (PLAU))

Andere Bezeichnung: PLAU (PLAU Produkte)

Synonyme: PLAU Protein, u-PA Protein, ATF Protein, BDPLT5 Protein, QPD Protein, UPA Protein, URK Protein, uPA Protein, UPAM Protein, plasminogen activator, urokinase Protein, urokinase-type plasminogen activator Protein, PLAU Protein, CpipJ_CPIJ002131 Protein, CpipJ_CPIJ006543 Protein, CpipJ_CPIJ013396 Protein, CpipJ_CPIJ013623 Protein, Plau Protein

Hintergrund: Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. PLAU inhibition could suppress tumor growth. Collectively, PLAU is necessary for tumor progression and can be a diagnostic and prognostic biomarker in HNSCC.

Molekulargewicht: 47.23 kDa. Due to protein lysis and glycosylation, the protein migrates to 23-25 kDa (long chain A), 35-40 kDa (chain B) and 50-60 kDa (long chain A&chain B) based on Tris-Bis PAGE result.

UniProt: A0A2K5WND1

Pathways: Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagie, Smooth Muscle Cell Migration