LRP5
(Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))
Protein-Typ
Recombinant
Proteineigenschaft
AA 644-1263
Spezies
Human
Quelle
HEK-293 Cells
Aufreinigungstag / Konjugat
Dieses LRP5 Protein ist gelabelt mit Fc Tag.
Verwendungszweck
Human LRP-5 Protein
Sequenz
Glu644-Gln1263
Produktmerkmale
Recombinant Human LRP-5 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Glu644-Gln1263.
Reinheit
> 95 % as determined by Tris-Bis PAGE
Sterilität
0.22 μm filtered
Endotoxin-Niveau
Less than 1EU per μg by the LAL method.
Biological Activity Comment
Immobilized Human DKK1, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Human LPR-5, hFc Tag with the EC50 of 0.62ug/ml determined by ELISA. See testing image for detail.
Crystallography grade
LRP5
Spezies: Human
Wirt: Insektenzellen
Recombinant
>95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
WB, SDS, ELISA, Crys
Crystallography grade
LRP5
Spezies: Human
Wirt: Insektenzellen
Recombinant
>95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
WB, SDS, ELISA, Crys
Crystallography grade
LRP5
Spezies: Human
Wirt: Insektenzellen
Recombinant
>95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
WB, SDS, ELISA, Crys
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
Supplied as 0.22μm filtered solution in PBS, 100 mM L-arginine ( pH 7.4).
Lagerung
-80 °C
Informationen zur Lagerung
Valid for 12 months from date of receipt when stored at -80°C.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Haltbarkeit
12 months
Target
LRP5
(Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))
Xlrp5 Protein, bmnd1 Protein, evr1 Protein, evr4 Protein, hbm Protein, lr3 Protein, lrp5-A Protein, lrp7 Protein, oppg Protein, ops Protein, opta1 Protein, vbch2 Protein, LRP5 Protein, LRP6 Protein, BMND1 Protein, EVR1 Protein, EVR4 Protein, HBM Protein, LR3 Protein, LRP7 Protein, OPPG Protein, OPS Protein, OPTA1 Protein, VBCH2 Protein, mKIAA4142 Protein, low-density lipoprotein receptor-related protein 5 Protein, LDL receptor related protein 5 Protein, LDL receptor related protein 5 L homeolog Protein, low density lipoprotein receptor-related protein 5 Protein, LDL receptor related protein 5 like Protein, LOC100147353 Protein, LRP5 Protein, lrp5.L Protein, lrp5 Protein, Lrp5 Protein, LRP5L Protein
Hintergrund
A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis.
Molekulargewicht
96.51 kDa. Due to glycosylation, the protein migrates to 100-115 kDa based on Tris-Bis PAGE result.