FcRn Protein (AA 22-297) (His tag)

Produktnummer ABIN7274677

Produktdetails

Target: FcRn (IgG receptor FcRn (FcRn))

Protein-Typ: Recombinant

Proteineigenschaft: AA 22-297

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses FcRn Protein ist gelabelt mit His tag.

Verwendungszweck: Mouse FcRn Protein

Sequenz: Ser22-Ser297 (FCGRT) & Ile21-Met119 (B2M)

Spezifität: Uni-Prot: Q61559 (FCGRT), P01887 (B2M)

Produktmerkmale: Recombinant Mouse FcRn Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ser22-Ser297 (FCGRT) & Ile21-Met119 (B2M).

Reinheit: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Biological Activity Comment: The affinity constant of 4.55 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: FcRn (IgG receptor FcRn (FcRn))

Andere Bezeichnung: FcRn (FcRn Produkte)

Synonyme: FCRN Protein, alpha-chain Protein, FcRn Protein, Fc fragment of IgG receptor and transporter Protein, Fc receptor, IgG, alpha chain transporter Protein, FCGRT Protein, Fcgrt Protein

Hintergrund: The neonatal Fc receptor (FCRN) is an approximately 45 kDa transmembrane glycoprotein with structural homology to MHC class I proteins. It is widely expressed in endothelial and epithelial cells and plays an important role in IgG homeostasis and antigen presentation by dendritic cells.FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51, and p14 , and forms an MHC class I-like heterodimer.

Molekulargewicht: 32.1 kDa (FCGRT)&11.7 kDa (B2M). Due to glycosylation, the protein migrates to 50-55 kDa (FCGRT)&14-15 kDa (B2M) based on Tris-Bis PAGE result.

UniProt: Q61559

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process