FcRn Produkte
(Fc gamma Receptor and Transporter (FCGRT))
Kategorien
The neonatal Fc receptor (FnRn) owes its name to being the receptor that transports maternal IgG from mother to lactating neonatal offspring and for being identified first in the intestine of neonatal rats as the receptor responsible for the transport of IgG from the lumen to the circulation. However, FcRn functions are far more universal, and it is virtually ubiquitously expressed.
FcRn is considered a non-classical Fc receptor for IgG (FcgR): it is structurally related to major histocompatibility class I (MHC-I) family and it associates with beta-2-microglobulin (b2m). On the other hand, it does not present antigenic peptides to T cells and. It has also a second interaction partner, albumin, that is not involved in the body’s immune response. FcRn prevents intracellular degradation of IgG and albumin and extends their half-life considerable, making them the two most abundant serum proteins.
Because of its interaction with IgG and albumin, FcRn has become a high-interest therapeutic target. For one, it can be exploited to extend the half-life of therapeutic antibodies and IgG- or albumin-fused proteins. To this end, mutations of amino acids influencing the pH dependency of IgG and albumin binding can be mutated to achieve the desired effect. Binding of IgG to FcRn also offers the possibility to enhance their clearance. Autoantibodies that recognized self-antigens are the cause of certain autoimmune diseases. By engineering competing antibodies that bind tighter to FcRn and effectively block the receptor increase clearance of the disease-causing antibodies. Lastly, the FcRn enhances the transport of therapeutic IgG fc or albumin fusion-protein across mucosal membranes, thus facilitating distribution and improving their absorption.
- proven mAb against human FcRn
- suitable for hFcRn blocking
- monoclonal antibody (FCGRT-2932)
- for IHC, ISt, StM
- In stock, fast delivery
antibodies-online.com steht für hochwertige Forschungsprodukte. Suchen, finden und bestellen Sie Tools mit umfangreichen Validierungsdaten, Bildern, Referenzen. Unser wissenschaftlicher Kundenservice steht Ihnen jederzeit zur Verfügung, wenn Sie Fragen zur Auswahl oder Anwendung unserer Produkte haben.
Ausgewählte FcRn Kategorien
FcRn Antikörper
High quality antibodies with extensive validation data.
FcRn ELISA Kits
Reliable ELISA kits for a wide range of species.
FcRn Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene FcRn Antikörper
- (7)
- (4)
- (4)
Empfohlene FcRn ELISA Kits
- (1)
- (1)
- (1)
Empfohlene FcRn Proteine
- (6)
- (6)
- (6)
Neueste Publikationen zu unseren FcRn Produkten
: "Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis." in: Nature communications, Vol. 13, Issue 1, pp. 662, (2022) (PubMed).: "Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention." in: JCI insight, Vol. 6, Issue 3, (2021) (PubMed).
: "Placental transfer of 125 iodinated humanized immunoglobulin G2Δa in the cynomolgus monkey." in: Birth defects research, Vol. 112, Issue 1, pp. 105-117, (2020) (PubMed).
: "Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, Issue 31, pp. 18754-18763, (2020) (PubMed).
: "Unidirectional transport of IgG by neonatal Fc receptor in human thyrocytes varies across different IgG subclasses." in: Molecular and cellular endocrinology, Vol. 477, pp. 103-111, (2019) (PubMed).
: "Control of therapeutic IgG antibodies galactosylation during cultivation process and its impact on IgG1/FcγR interaction and ADCC activity." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 58, pp. 16-21, (2019) (PubMed).
: "FcRn-Dependent Transcytosis of Monoclonal Antibody in Human Nasal Epithelial Cells In Vitro: A Prerequisite for a New Delivery Route for Therapy?" in: International journal of molecular sciences, Vol. 20, Issue 6, (2019) (PubMed).
: "Comparative studies of the serum half-life extension of a protein via site-specific conjugation to a species-matched or -mismatched albumin." in: Biomaterials science, Vol. 6, Issue 8, pp. 2092-2100, (2018) (PubMed).
: "The Neonatal Fc Receptor and Complement Fixation Facilitate Prophylactic Vaccine-Mediated Humoral Protection against Viral Infection in the Ocular Mucosa." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 199, Issue 5, pp. 1898-1911, (2017) (PubMed).
: "Distribution of FcRn Across Species and Tissues." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 65, Issue 6, pp. 321-333, (2017) (PubMed).
Synonyme und alternative Namen zu FcRn
Fc fragment of IgG receptor and transporter (FCGRT), Fc fragment of IgG receptor and transporter (Fcgrt), Fc receptor, IgG, alpha chain transporter (Fcgrt), alpha-chain, FCRN, FcRnBezeichner auf Proteinebene für FcRn
- FcRn alpha chain
- IgG Fc fragment receptor transporter alpha chain
- IgG receptor FcRn large subunit p51
- immunoglobulin receptor, intestinal, heavy chain
- major histocompatibility complex class I-like Fc receptor
- neonatal Fc receptor
- neonatal Fc-receptor for Ig
- IgG transcytosis and recycling receptor
- MHC class I-related Fc gamma receptor
- igG receptor FcRn large subunit p51
- neonatal Fc receptor FcRn
- Fc receptor
- Fc fragment immunoglobulin G receptor
- Fc receptor, IgG, alpha chain transporter
- igG Fc fragment receptor transporter alpha chain
