CD137 Protein (AA 24-186) (His tag)

Produktnummer ABIN7273921

Produktdetails

Target: CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))

Protein-Typ: Recombinant

Proteineigenschaft: AA 24-186

Spezies: Cynomolgus, Rhesusaffen

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses CD137 Protein ist gelabelt mit His tag.

Verwendungszweck: Cynomolgus/Rhesus macaque 4-1BB/TNFRSF9 Protein

Sequenz: Leu24-Gln186

Produktmerkmale: Recombinant Cynomolgus/Rhesus macaque 4-1BB/TNFRSF9 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu24-Gln186.

Reinheit: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Biological Activity Comment: Immobilized Cynomolgus/Rhesus macaque 4-1BB, His Tag at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Cynomolgus 4-1BB Ligand, hFc Tag with the EC50 of 6.7ng/ml determined by ELISA. See testing image for detail.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))

Andere Bezeichnung: 4-1BB (TNFRSF9 Produkte)

Synonyme: TNFRSF9 Protein, zgc:136557 Protein, 4-1BB Protein, CD137 Protein, CDw137 Protein, ILA Protein, A930040I11Rik Protein, AA408498 Protein, AI325004 Protein, Cd137 Protein, Ly63 Protein, tumor necrosis factor receptor superfamily member 9 Protein, TNF receptor superfamily member 9 Protein, tumor necrosis factor receptor superfamily, member 9a Protein, tumor necrosis factor receptor superfamily, member 9 Protein, TNFRSF9 Protein, tnfrsf9a Protein, Tnfrsf9 Protein

Hintergrund: 4-1BB, is also known as CD137, is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily.CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, B cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation.

Molekulargewicht: 18.4 kDa. Due to glycosylation, the protein migrates to 30-40 kDa based on Tris-Bis PAGE result.

NCBI Accession: XP_005544945

Pathways: Cancer Immune Checkpoints