FGF19 Protein (His tag)

Produktnummer ABIN7318482

Produktdetails

Target: FGF19 (Fibroblast Growth Factor 19 (FGF19))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses FGF19 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human FGF-19/FGF9 Protein (His Tag)(Active)

Sequenz: Phe27-Lys216

Produktmerkmale: Recombinant Human Fibroblast growth factor 19 is produced by our E.coli expression system and the target gene encoding Phe27-Lys216 is expressed with a 6His tag at the N-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Immobilized Human FGF-19-His at 2μg/ml(100 μl/well) can bind Human FGFR3-Fc(Cat: PKSH033678). The ED50 of Human FGF-19-His is 3.1135 ug/ml.

Anwendungsinformationen

Kommentare:

24 kDa

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: FGF19 (Fibroblast Growth Factor 19 (FGF19))

Andere Bezeichnung: FGF-19 (FGF19 Produkte)

Synonyme: FGF-19 Protein, Fgf15 Protein, fibroblast growth factor 19 Protein, FGF19 Protein, Fgf19 Protein, fgf19 Protein

Hintergrund:

Background: Fibroblast growth factor 19 (FGF19) is a secreted protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity. FGFRs can be important for regulation of glucose and lipid homeostasis. FGF19 has important roles as a hormone produced in the ileum in response to bile acid absorption. It has been shown to cause resistance to diet-induced obesity and insulin desensitization and to improve insulin, glucose, and lipid profiles in diabetic rodents. FGF19 can be considered as a regulator of energy expenditure.

Synonym: Fibroblast growth factor 19, FGF-19, FGF19

Molekulargewicht: 23.5 kDa

UniProt: O95750

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung